PLoS Computational Biology • Vol 20 • No 9
Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments
September 2024 • Janice Yang, Neil Daily, Taylor K. Pullinger, Tetsuro Wakatsuki, Eric A. Sobie
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have gained traction as a powerful model in cardiac disease and therapeutics research, since iPSCs are self-renewing and can be derived from healthy and diseased patients without invasive surgery. However, current iPSC-CM differentiation methods produce cardiomyocytes with immature, fetal-like electrophysiological phenotypes, and the variety of maturation protocols in the literature results in phenotypic differences between labs. Heterogeneity o…