Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases Article Swipe
Wenxuan Zhou
,
Shengli Xia
,
Chenmeng Wang
,
Qingwu Yang
,
Alexei Verkhratsky
,
Jianqin Niu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-025-07893-6
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-025-07893-6
Rodents are the most commonly used laboratory animals in medical research. However, significant evolutionary divergences between humans and rodents, particularly in the complexity of white matter connectome, which are fundamentally shaped by myelin as their major structural component, pose critical challenges in modeling the human neurological diseases. Given the divergences and central roles of myelin in pathology, a thorough reevaluation of the rodent models used in contemporary research is critical, alongside the careful selection, optimization, or de novo development of models that faithfully recapitulate human white matter disorders. In this review, we summarize the strengths and limitations of existing rodent models, emphasizing their contributions to understanding demyelinating pathologies across autoimmune, neurodegenerative, vascular, perinatal, traumatic, infectious and genetic diseases. We also overview white mater disease models using other species and human stem cells. Subsequently we discuss critical interspecies differences in white matter biology that may limit translational relevance, while highlighting how rodent models enhance our comprehension of various pathological conditions. Lastly, we outline strategies to refine rodent models through advanced genetic engineering, humanized microenvironments, and multimodal phenotyping, with the goal of progressively improving existing them to increase their preclinical translational potentials.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41419-025-07893-6
- https://www.nature.com/articles/s41419-025-07893-6.pdf
- OA Status
- gold
- Cited By
- 3
- References
- 476
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412800508
All OpenAlex metadata
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https://openalex.org/W4412800508Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41419-025-07893-6Digital Object Identifier
- Title
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Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseasesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-31Full publication date if available
- Authors
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Wenxuan Zhou, Shengli Xia, Chenmeng Wang, Qingwu Yang, Alexei Verkhratsky, Jianqin NiuList of authors in order
- Landing page
-
https://doi.org/10.1038/s41419-025-07893-6Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41419-025-07893-6.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41419-025-07893-6.pdfDirect OA link when available
- Concepts
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White matter, Rodent model, Rodent, Pathology, Biology, Translational research, Computational biology, Medicine, Ecology, Magnetic resonance imaging, Radiology, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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476Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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