Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus Article Swipe
Yuko Asanuma
,
Kazuhisa NOZAWA
,
Masakazu Matsushita
,
Makio Kusaoi
,
Yoshiyuki Abe
,
Ken Yamaji
,
Naoto Tamura
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2023.e19072
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2023.e19072
In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE. As Mannose-binding lectin-associated serine proteases (MASPs) are associated with activation of the lectin pathway, we conducted this study to clarify MASPs associations in the pathogenesis of SLE. We evaluated the serum level of MASPs (MASP-1 and MASP-2) in total 68 SLE patients consisting of 15 patients with biopsy-confirmed membranous lupus nephritis (M-LN), 35 patients with biopsy-confirmed proliferative lupus nephritis (P-LN), and 18 SLE patients without LN (non-LN). Our data showed that the serum levels of MASPs were reduced in both P-LN and non-LN although those of M-LN were not reduced. Our data show that the lectin pathway mediated by MASPs plays a critical role for the pathogenesis of SLE except for M-LN.
Related Topics
Concepts
Lectin pathway
Pathogenesis
Mannan-binding lectin
Complement system
Proteases
Lupus nephritis
Immunology
Lectin
Alternative complement pathway
Medicine
Biology
Pathology
Biochemistry
Immune system
Enzyme
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.heliyon.2023.e19072
- http://www.cell.com/article/S2405844023062801/pdf
- OA Status
- gold
- Cited By
- 6
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385721057
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385721057Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.heliyon.2023.e19072Digital Object Identifier
- Title
-
Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosusWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-01Full publication date if available
- Authors
-
Yuko Asanuma, Kazuhisa NOZAWA, Masakazu Matsushita, Makio Kusaoi, Yoshiyuki Abe, Ken Yamaji, Naoto TamuraList of authors in order
- Landing page
-
https://doi.org/10.1016/j.heliyon.2023.e19072Publisher landing page
- PDF URL
-
https://www.cell.com/article/S2405844023062801/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.cell.com/article/S2405844023062801/pdfDirect OA link when available
- Concepts
-
Lectin pathway, Pathogenesis, Mannan-binding lectin, Complement system, Proteases, Lupus nephritis, Immunology, Lectin, Alternative complement pathway, Medicine, Biology, Pathology, Biochemistry, Immune system, Enzyme, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 4Per-year citation counts (last 5 years)
- References (count)
-
17Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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