Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination Article Swipe
Ayae Nishiyama
,
Takuto Nogimori
,
Yuji Masuta
,
Tomoka Matsuura
,
Tetsuo Kase
,
Kyoko Kondo
,
Satoko Ohfuji
,
Yu Nakagama
,
Natsuko Kaku
,
Sachie Nakagama
,
Yuko Nitahara
,
Yoshimasa Takahashi
,
Hiroshi Kakeya
,
Yasutoshi Kido
,
Wakaba Fukushima
,
Takuya Yamamoto
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/vaccines13020140
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/vaccines13020140
Background: Current influenza A vaccines primarily induce neutralizing antibodies targeting the variable hemagglutinin (HA) head domain, limiting their effectiveness against diverse or emerging influenza A virus (IAV) subtypes. The conserved HA stem domain, particularly the long α-helix (LAH) epitope, is a focus of universal vaccine research due to its cross-protective potential. Additionally, Fc-mediated functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) are recognized as important protective immune mechanisms. This study evaluated IgG responses to the HA head, stem, and LAH regions and assessed cross-reactive potential through neutralization, ADCC, and ADCP assays. Methods: IgG responses to the HA head, stem, and LAH regions were measured in vaccinated individuals. Functional assays were conducted for neutralization, ADCC, and ADCP to evaluate the association between antibody levels and immune function. Results: The results showed that HA head-specific IgG increased significantly after vaccination in 50 individuals, whereas stem-specific IgG increased by 72% and LAH-specific IgG by 12–14%. Among the induced antibody subclasses, IgG1 was predominantly increased. Neutralization titers were detected in viruses of the same strain as the vaccine strain, but not in classical or pandemic strains (H5N1, H7N9). HA stem-specific IgG1 antibody titers showed a significant correlation with ADCC/ADCP activity breadth, but no correlation was observed with neutralization breadth. Conclusions: These findings suggest that although current influenza vaccines can induce HA stem-targeted cross-reactive antibodies, their quantity may be insufficient for broad cross-protection, underscoring the need for improved vaccine strategies.
Related Topics
Concepts
Antibody-dependent cell-mediated cytotoxicity
Hemagglutinin (influenza)
Antibody
Virology
Biology
Immune system
Neutralization
Antibody titer
Vaccination
Titer
Immunoglobulin G
Immunology
Monoclonal antibody
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/vaccines13020140
- OA Status
- gold
- Cited By
- 1
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406933524
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406933524Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/vaccines13020140Digital Object Identifier
- Title
-
Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal VaccinationWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-28Full publication date if available
- Authors
-
Ayae Nishiyama, Takuto Nogimori, Yuji Masuta, Tomoka Matsuura, Tetsuo Kase, Kyoko Kondo, Satoko Ohfuji, Yu Nakagama, Natsuko Kaku, Sachie Nakagama, Yuko Nitahara, Yoshimasa Takahashi, Hiroshi Kakeya, Yasutoshi Kido, Wakaba Fukushima, Takuya YamamotoList of authors in order
- Landing page
-
https://doi.org/10.3390/vaccines13020140Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/vaccines13020140Direct OA link when available
- Concepts
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Antibody-dependent cell-mediated cytotoxicity, Hemagglutinin (influenza), Antibody, Virology, Biology, Immune system, Neutralization, Antibody titer, Vaccination, Titer, Immunoglobulin G, Immunology, Monoclonal antibodyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
-
38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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