Cross-Reactive Immune Response of Bovine Coronavirus Spike Glycoprotein to SARS-CoV-2 Variants of Concern Article Swipe
Chiara Cossu
,
Valentina Franceschi
,
Antonino Di Lorenzo
,
Elisabetta Bolli
,
Sergio Minesso
,
Camilla Cotti
,
Laura Conti
,
Gaetano Donofrío
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms252111509
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms252111509
The high variability observed in the clinical symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has been attributed to the presence, in a proportion of infection-naive subjects, of pre-existing cross-reactive immune responses. Here, we demonstrate that the bovine coronavirus spike protein (BoS) may represent a source of protective immunity to SARS-CoV-2. Indeed, vaccination of BALB/c mice with a Bovine herpesvirus 4 (BoHV-4)-based vector expressing BoS induced both cell-mediated and humoral immune responses that cross-react with SARS-CoV-2 spike protein. Although the spike-specific antibodies induced by BoS did not neutralize SARS-CoV-2, the T lymphocytes activated by BoS were able to induce cytotoxicity of cells expressing spike proteins derived from several SARS-CoV-2 variants. These results demonstrate that immunization with BoS may represent a source of cross-reactive immunity to SARS-CoV-2, and that these cross-reactive immune responses may exert protective functions. These results contribute to deciphering the mechanisms responsible for lack or mildness of symptoms observed in many individuals upon SARS-CoV-2 infection and may open new ways for the development of new vaccines for coronaviruses.
Related Topics
Concepts
Immune system
Coronavirus
Biology
Immunity
Antibody
Glycoprotein
Immunology
Immunization
Virology
Vaccination
Cellular immunity
Coronavirus disease 2019 (COVID-19)
Medicine
Genetics
Disease
Pathology
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms252111509
- OA Status
- gold
- Cited By
- 2
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403845164
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403845164Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms252111509Digital Object Identifier
- Title
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Cross-Reactive Immune Response of Bovine Coronavirus Spike Glycoprotein to SARS-CoV-2 Variants of ConcernWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-10-26Full publication date if available
- Authors
-
Chiara Cossu, Valentina Franceschi, Antonino Di Lorenzo, Elisabetta Bolli, Sergio Minesso, Camilla Cotti, Laura Conti, Gaetano DonofríoList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms252111509Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/ijms252111509Direct OA link when available
- Concepts
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Immune system, Coronavirus, Biology, Immunity, Antibody, Glycoprotein, Immunology, Immunization, Virology, Vaccination, Cellular immunity, Coronavirus disease 2019 (COVID-19), Medicine, Genetics, Disease, Pathology, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
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34Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.7788094 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |