Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.1136/bmjopen-2021-054160
Background 70%–84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizophrenia has indicated that verbal memory and language functions may be more impaired in treatment resistance. We sought to confirm this finding by comparing cognitive performance between antipsychotic non-responders (NR) and responders (R) using a brief cognitive battery for schizophrenia, with a primary focus on verbal tasks compared against other measures of cognition. Design Cross-sectional. Setting This cross-sectional study recruited antipsychotic treatment R and antipsychotic NR across four UK sites. Cognitive performance was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS). Participants One hundred and six participants aged 18–65 years with a diagnosis of schizophrenia or schizophreniform disorder were recruited according to their treatment response, with 52 NR and 54 R cases. Outcomes Composite and subscale scores of cognitive performance on the BACS. Group (R vs NR) differences in cognitive scores were investigated using univariable and multivariable linear regressions adjusted for age, gender and illness duration. Results Univariable regression models observed no significant differences between R and NR groups on any measure of the BACS, including verbal memory (ß=−1.99, 95% CI −6.63 to 2.66, p=0.398) and verbal fluency (ß=1.23, 95% CI −2.46 to 4.91, p=0.510). This pattern of findings was consistent in multivariable models. Conclusions The lack of group difference in cognition in our sample is likely due to a lack of clinical distinction between our groups. Future investigations should aim to use machine learning methods using longitudinal first episode samples to identify responder subtypes within schizophrenia, and how cognitive factors may interact within this. Trail registration number REC: 15/LO/0038.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2021-054160
- https://bmjopen.bmj.com/content/bmjopen/11/11/e054160.full.pdf
- OA Status
- gold
- Cited By
- 6
- References
- 81
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3209771402
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3209771402Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/bmjopen-2021-054160Digital Object Identifier
- Title
-
Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-11-01Full publication date if available
- Authors
-
Edward Millgate, Eugenia Kravariti, Alice Egerton, Oliver Howes, Robin Murray, Laura Kassoumeri, J Donocik, Shôn Lewis, Richard Drake, Stephen M. Lawrie, Anna Murphy, Tracy Collier, Jane Lees, Charlotte Stockton-Powdrell, James Walters, J.F.W. Deakin, James H. MacCabeList of authors in order
- Landing page
-
https://doi.org/10.1136/bmjopen-2021-054160Publisher landing page
- PDF URL
-
https://bmjopen.bmj.com/content/bmjopen/11/11/e054160.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://bmjopen.bmj.com/content/bmjopen/11/11/e054160.full.pdfDirect OA link when available
- Concepts
-
Schizophrenia (object-oriented programming), Verbal fluency test, Cognition, Medicine, Cross-sectional study, Verbal memory, Schizophreniform disorder, Antipsychotic, Psychiatry, Clinical psychology, Psychosis, Verbal learning, Effects of sleep deprivation on cognitive performance, Schizoaffective disorder, Neuropsychology, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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81Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].display_name | Quality Education |
| citation_normalized_percentile.value | 0.62695148 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |