Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture Article Swipe
Madison R. Glass
,
Elisa A. Waxman
,
Satoshi Yamashita
,
Michael J. Lafferty
,
Alvaro A. Beltran
,
Tala M. Farah
,
Niyanta K Patel
,
Rubal Singla
,
Nana Matoba
,
Sara M. Ahmed
,
Mary Srivastava
,
Emma Drake
,
Liam T. Davis
,
Meghana Yeturi
,
Kexin Sun
,
Michael I. Love
,
Kazue Hashimoto‐Torii
,
Deborah L. French
,
Jason L. Stein
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.stemcr.2024.07.008
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.stemcr.2024.07.008
While guided human cortical organoid (hCO) protocols reproducibly generate cortical cell types at one site, variability in hCO phenotypes across sites using a harmonized protocol has not yet been evaluated. To determine the cross-site reproducibility of hCO differentiation, three independent research groups assayed hCOs in multiple differentiation replicates from one induced pluripotent stem cell (iPSC) line using a harmonized miniaturized spinning bioreactor protocol across 3 months. hCOs were mostly cortical progenitor and neuronal cell types in reproducible proportions that were consistently organized in cortical wall-like buds. Cross-site differences were detected in hCO size and expression of metabolism and cellular stress genes. Variability in hCO phenotypes correlated with stem cell gene expression prior to differentiation and technical factors associated with seeding, suggesting iPSC quality and treatment are important for differentiation outcomes. Cross-site reproducibility of hCO cell type proportions and organization encourages future prospective meta-analytic studies modeling neurodevelopmental disorders in hCOs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.stemcr.2024.07.008
- OA Status
- gold
- Cited By
- 14
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401825233
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401825233Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.stemcr.2024.07.008Digital Object Identifier
- Title
-
Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architectureWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-23Full publication date if available
- Authors
-
Madison R. Glass, Elisa A. Waxman, Satoshi Yamashita, Michael J. Lafferty, Alvaro A. Beltran, Tala M. Farah, Niyanta K Patel, Rubal Singla, Nana Matoba, Sara M. Ahmed, Mary Srivastava, Emma Drake, Liam T. Davis, Meghana Yeturi, Kexin Sun, Michael I. Love, Kazue Hashimoto‐Torii, Deborah L. French, Jason L. SteinList of authors in order
- Landing page
-
https://doi.org/10.1016/j.stemcr.2024.07.008Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.stemcr.2024.07.008Direct OA link when available
- Concepts
-
Biology, Organoid, Induced pluripotent stem cell, Progenitor cell, Cell type, Stem cell, Cellular differentiation, Phenotype, Cell biology, Cell, Reproducibility, Computational biology, Neuroscience, Gene, Embryonic stem cell, Genetics, Chemistry, ChromatographyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
14Total citation count in OpenAlex
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-
2025: 10, 2024: 4Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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