Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma Article Swipe
Joëlle S. Nader
,
Alice Boissard
,
Cécile Henry
,
Isabelle Valo
,
Véronique Verrièle
,
Marc Grégoire
,
Olivier Coqueret
,
Catherine Guette
,
Daniel Pouliquen
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12092430
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12092430
Malignant mesothelioma (MM) still represents a devastating disease that is often detected too late, while the current effect of therapies on patient outcomes remains unsatisfactory. Invasiveness biomarkers may contribute to improving early diagnosis, prognosis, and treatment for patients, a task that could benefit from the development of high-throughput proteomics. To limit potential sources of bias when identifying such biomarkers, we conducted cross-species proteomic analyzes on three different MM sources. Data were collected firstly from two human MM cell lines, secondly from rat MM tumors of increasing invasiveness grown in immunocompetent rats and human MM tumors grown in immunodeficient mice, and thirdly from paraffin-embedded sections of patient MM tumors of the epithelioid and sarcomatoid subtypes. Our investigations identified three major invasiveness biomarkers common to the three tumor sources, CAPG, FABP4, and LAMB2, and an additional set of 25 candidate biomarkers shared by rat and patient tumors. Comparing the data to proteomic analyzes of preneoplastic and neoplastic rat mesothelial cell lines revealed the additional role of SBP1 in the carcinogenic process. These observations could provide new opportunities to identify highly vulnerable MM patients with poor survival outcomes, thereby improving the success of current and future therapeutic strategies.
Related Topics
Concepts
Mesothelioma
Proteomics
Cancer research
Pathology
Biomarker
Medicine
Biology
Disease
Biomarker discovery
Bioinformatics
Gene
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers12092430
- https://www.mdpi.com/2072-6694/12/9/2430/pdf?version=1598512911
- OA Status
- gold
- Cited By
- 12
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3081448816
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3081448816Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers12092430Digital Object Identifier
- Title
-
Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant MesotheliomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-27Full publication date if available
- Authors
-
Joëlle S. Nader, Alice Boissard, Cécile Henry, Isabelle Valo, Véronique Verrièle, Marc Grégoire, Olivier Coqueret, Catherine Guette, Daniel PouliquenList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers12092430Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/12/9/2430/pdf?version=1598512911Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/12/9/2430/pdf?version=1598512911Direct OA link when available
- Concepts
-
Mesothelioma, Proteomics, Cancer research, Pathology, Biomarker, Medicine, Biology, Disease, Biomarker discovery, Bioinformatics, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 3, 2022: 6, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3081448816 |
|---|---|
| doi | https://doi.org/10.3390/cancers12092430 |
| ids.doi | https://doi.org/10.3390/cancers12092430 |
| ids.mag | 3081448816 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32867073 |
| ids.openalex | https://openalex.org/W3081448816 |
| fwci | 2.31886449 |
| type | article |
| title | Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma |
| awards[0].id | https://openalex.org/G7889001444 |
| awards[0].funder_id | https://openalex.org/F4320322363 |
| awards[0].funder_award_id | R17029NN |
| awards[0].funder_display_name | Ligue Contre le Cancer |
| biblio.issue | 9 |
| biblio.volume | 12 |
| biblio.last_page | 2430 |
| biblio.first_page | 2430 |
| grants[0].funder | https://openalex.org/F4320322363 |
| grants[0].award_id | R17029NN |
| grants[0].funder_display_name | Ligue Contre le Cancer |
| topics[0].id | https://openalex.org/T11026 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Occupational and environmental lung diseases |
| topics[1].id | https://openalex.org/T13759 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9763000011444092 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Medical Imaging and Pathology Studies |
| topics[2].id | https://openalex.org/T10870 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9490000009536743 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis |
| funders[0].id | https://openalex.org/F4320322363 |
| funders[0].ror | https://ror.org/00rkrv905 |
| funders[0].display_name | Ligue Contre le Cancer |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| concepts[0].id | https://openalex.org/C2777407522 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7675963044166565 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1077603 |
| concepts[0].display_name | Mesothelioma |
| concepts[1].id | https://openalex.org/C46111723 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5781248807907104 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q471857 |
| concepts[1].display_name | Proteomics |
| concepts[2].id | https://openalex.org/C502942594 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5104188323020935 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[2].display_name | Cancer research |
| concepts[3].id | https://openalex.org/C142724271 |
| concepts[3].level | 1 |
| concepts[3].score | 0.49845051765441895 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[3].display_name | Pathology |
| concepts[4].id | https://openalex.org/C2781197716 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4946863353252411 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q864574 |
| concepts[4].display_name | Biomarker |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.47693461179733276 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.42536816000938416 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C2779134260 |
| concepts[7].level | 2 |
| concepts[7].score | 0.42217540740966797 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[7].display_name | Disease |
| concepts[8].id | https://openalex.org/C124535831 |
| concepts[8].level | 4 |
| concepts[8].score | 0.4158497452735901 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q4915074 |
| concepts[8].display_name | Biomarker discovery |
| concepts[9].id | https://openalex.org/C60644358 |
| concepts[9].level | 1 |
| concepts[9].score | 0.354489803314209 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[9].display_name | Bioinformatics |
| concepts[10].id | https://openalex.org/C104317684 |
| concepts[10].level | 2 |
| concepts[10].score | 0.12865564227104187 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[10].display_name | Gene |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/mesothelioma |
| keywords[0].score | 0.7675963044166565 |
| keywords[0].display_name | Mesothelioma |
| keywords[1].id | https://openalex.org/keywords/proteomics |
| keywords[1].score | 0.5781248807907104 |
| keywords[1].display_name | Proteomics |
| keywords[2].id | https://openalex.org/keywords/cancer-research |
| keywords[2].score | 0.5104188323020935 |
| keywords[2].display_name | Cancer research |
| keywords[3].id | https://openalex.org/keywords/pathology |
| keywords[3].score | 0.49845051765441895 |
| keywords[3].display_name | Pathology |
| keywords[4].id | https://openalex.org/keywords/biomarker |
| keywords[4].score | 0.4946863353252411 |
| keywords[4].display_name | Biomarker |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.47693461179733276 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.42536816000938416 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/disease |
| keywords[7].score | 0.42217540740966797 |
| keywords[7].display_name | Disease |
| keywords[8].id | https://openalex.org/keywords/biomarker-discovery |
| keywords[8].score | 0.4158497452735901 |
| keywords[8].display_name | Biomarker discovery |
| keywords[9].id | https://openalex.org/keywords/bioinformatics |
| keywords[9].score | 0.354489803314209 |
| keywords[9].display_name | Bioinformatics |
| keywords[10].id | https://openalex.org/keywords/gene |
| keywords[10].score | 0.12865564227104187 |
| keywords[10].display_name | Gene |
| language | en |
| locations[0].id | doi:10.3390/cancers12092430 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S168415115 |
| locations[0].source.issn | 2072-6694 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2072-6694 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancers |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2072-6694/12/9/2430/pdf?version=1598512911 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancers |
| locations[0].landing_page_url | https://doi.org/10.3390/cancers12092430 |
| locations[1].id | pmid:32867073 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancers |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32867073 |
| locations[2].id | pmh:oai:mdpi.com:/2072-6694/12/9/2430/ |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400947 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | True |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | MDPI (MDPI AG) |
| locations[2].source.host_organization | https://openalex.org/I4210097602 |
| locations[2].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[2].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Cancers; Volume 12; Issue 9; Pages: 2430 |
| locations[2].landing_page_url | https://dx.doi.org/10.3390/cancers12092430 |
| locations[3].id | pmh:oai:HAL:inserm-02945810v1 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306402512 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[3].source.host_organization | https://openalex.org/I1294671590 |
| locations[3].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[3].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Journal articles |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Cancers, 2020, ⟨10.3390/cancers12092430⟩ |
| locations[3].landing_page_url | https://inserm.hal.science/inserm-02945810 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:7564583 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Cancers (Basel) |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7564583 |
| locations[5].id | pmh:oai:doaj.org/article:8fb6114dbec8436b81ff15a836a933b5 |
| locations[5].is_oa | False |
| locations[5].source.id | https://openalex.org/S4306401280 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[5].source.host_organization | |
| locations[5].source.host_organization_name | |
| locations[5].source.host_organization_lineage | |
| locations[5].license | |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | article |
| locations[5].license_id | |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Cancers, Vol 12, Iss 2430, p 2430 (2020) |
| locations[5].landing_page_url | https://doaj.org/article/8fb6114dbec8436b81ff15a836a933b5 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5114376548 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-0378-3966 |
| authorships[0].author.display_name | Joëlle S. Nader |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I97188460 |
| authorships[0].affiliations[0].raw_affiliation_string | Université de Nantes, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[0].institutions[0].id | https://openalex.org/I154526488 |
| authorships[0].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Inserm |
| authorships[0].institutions[1].id | https://openalex.org/I97188460 |
| authorships[0].institutions[1].ror | https://ror.org/03gnr7b55 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I97188460 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Nantes Université |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Joëlle S. Nader |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Université de Nantes, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[1].author.id | https://openalex.org/A5004582836 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Alice Boissard |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| authorships[1].affiliations[0].raw_affiliation_string | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[1].institutions[0].id | https://openalex.org/I154526488 |
| authorships[1].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Inserm |
| authorships[1].institutions[1].id | https://openalex.org/I49451733 |
| authorships[1].institutions[1].ror | https://ror.org/04yrqp957 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I49451733 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Université d'Angers |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Alice Boissard |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[2].author.id | https://openalex.org/A5108354666 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Cécile Henry |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| authorships[2].affiliations[0].raw_affiliation_string | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[2].institutions[0].id | https://openalex.org/I154526488 |
| authorships[2].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Inserm |
| authorships[2].institutions[1].id | https://openalex.org/I49451733 |
| authorships[2].institutions[1].ror | https://ror.org/04yrqp957 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I49451733 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Université d'Angers |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Cécile Henry |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[3].author.id | https://openalex.org/A5103003176 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1564-4058 |
| authorships[3].author.display_name | Isabelle Valo |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| authorships[3].affiliations[0].raw_affiliation_string | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[3].institutions[0].id | https://openalex.org/I154526488 |
| authorships[3].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Inserm |
| authorships[3].institutions[1].id | https://openalex.org/I49451733 |
| authorships[3].institutions[1].ror | https://ror.org/04yrqp957 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I49451733 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Université d'Angers |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Isabelle Valo |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[4].author.id | https://openalex.org/A5083974898 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-3463-3207 |
| authorships[4].author.display_name | Véronique Verrièle |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| authorships[4].affiliations[0].raw_affiliation_string | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[4].institutions[0].id | https://openalex.org/I154526488 |
| authorships[4].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Inserm |
| authorships[4].institutions[1].id | https://openalex.org/I49451733 |
| authorships[4].institutions[1].ror | https://ror.org/04yrqp957 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I49451733 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Université d'Angers |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Véronique Verrièle |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[5].author.id | https://openalex.org/A5103149966 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3868-0198 |
| authorships[5].author.display_name | Marc Grégoire |
| authorships[5].countries | FR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I97188460 |
| authorships[5].affiliations[0].raw_affiliation_string | Université de Nantes, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[5].institutions[0].id | https://openalex.org/I154526488 |
| authorships[5].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[5].institutions[0].type | government |
| authorships[5].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[5].institutions[0].country_code | FR |
| authorships[5].institutions[0].display_name | Inserm |
| authorships[5].institutions[1].id | https://openalex.org/I97188460 |
| authorships[5].institutions[1].ror | https://ror.org/03gnr7b55 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I97188460 |
| authorships[5].institutions[1].country_code | FR |
| authorships[5].institutions[1].display_name | Nantes Université |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Marc Grégoire |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Université de Nantes, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[6].author.id | https://openalex.org/A5031705295 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-2843-7867 |
| authorships[6].author.display_name | Olivier Coqueret |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| authorships[6].affiliations[0].raw_affiliation_string | Université d’Angers, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[6].institutions[0].id | https://openalex.org/I154526488 |
| authorships[6].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Inserm |
| authorships[6].institutions[1].id | https://openalex.org/I49451733 |
| authorships[6].institutions[1].ror | https://ror.org/04yrqp957 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I49451733 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Université d'Angers |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Olivier Coqueret |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Université d’Angers, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[7].author.id | https://openalex.org/A5036430313 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-1779-9931 |
| authorships[7].author.display_name | Catherine Guette |
| authorships[7].countries | FR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| authorships[7].affiliations[0].raw_affiliation_string | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[7].institutions[0].id | https://openalex.org/I154526488 |
| authorships[7].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[7].institutions[0].country_code | FR |
| authorships[7].institutions[0].display_name | Inserm |
| authorships[7].institutions[1].id | https://openalex.org/I49451733 |
| authorships[7].institutions[1].ror | https://ror.org/04yrqp957 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I49451733 |
| authorships[7].institutions[1].country_code | FR |
| authorships[7].institutions[1].display_name | Université d'Angers |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Catherine Guette |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Université d’Angers, ICO Cancer Center, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[8].author.id | https://openalex.org/A5084555157 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-0820-3828 |
| authorships[8].author.display_name | Daniel Pouliquen |
| authorships[8].countries | FR |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| authorships[8].affiliations[0].raw_affiliation_string | Université d’Angers, Inserm, CRCINA, F-44000 Nantes, France |
| authorships[8].institutions[0].id | https://openalex.org/I154526488 |
| authorships[8].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[8].institutions[0].type | government |
| authorships[8].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[8].institutions[0].country_code | FR |
| authorships[8].institutions[0].display_name | Inserm |
| authorships[8].institutions[1].id | https://openalex.org/I49451733 |
| authorships[8].institutions[1].ror | https://ror.org/04yrqp957 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I49451733 |
| authorships[8].institutions[1].country_code | FR |
| authorships[8].institutions[1].display_name | Université d'Angers |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Daniel L. Pouliquen |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Université d’Angers, Inserm, CRCINA, F-44000 Nantes, France |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2072-6694/12/9/2430/pdf?version=1598512911 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11026 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Occupational and environmental lung diseases |
| related_works | https://openalex.org/W2002038251, https://openalex.org/W112583468, https://openalex.org/W96119380, https://openalex.org/W3023706879, https://openalex.org/W4298030740, https://openalex.org/W1539981706, https://openalex.org/W1485011350, https://openalex.org/W4404588215, https://openalex.org/W2108949684, https://openalex.org/W4233701783 |
| cited_by_count | 12 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 3 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 6 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 2 |
| locations_count | 6 |
| best_oa_location.id | doi:10.3390/cancers12092430 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S168415115 |
| best_oa_location.source.issn | 2072-6694 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2072-6694 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancers |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2072-6694/12/9/2430/pdf?version=1598512911 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancers |
| best_oa_location.landing_page_url | https://doi.org/10.3390/cancers12092430 |
| primary_location.id | doi:10.3390/cancers12092430 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S168415115 |
| primary_location.source.issn | 2072-6694 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2072-6694 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancers |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2072-6694/12/9/2430/pdf?version=1598512911 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancers |
| primary_location.landing_page_url | https://doi.org/10.3390/cancers12092430 |
| publication_date | 2020-08-27 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2961780602, https://openalex.org/W2822628871, https://openalex.org/W1865089236, https://openalex.org/W2794715809, https://openalex.org/W2280299238, https://openalex.org/W2115785123, https://openalex.org/W2089705824, https://openalex.org/W2140690632, https://openalex.org/W2120191503, https://openalex.org/W1992332829, https://openalex.org/W2967543525, https://openalex.org/W4234157358, https://openalex.org/W3032431249, https://openalex.org/W2897299514, https://openalex.org/W2342562028, https://openalex.org/W3037243834, https://openalex.org/W2999095392, https://openalex.org/W3015348362, https://openalex.org/W2083140629, https://openalex.org/W2070111293, https://openalex.org/W2070572010, https://openalex.org/W2081170087, https://openalex.org/W2016867749, https://openalex.org/W2799727477, https://openalex.org/W2221103957, https://openalex.org/W6761678586, https://openalex.org/W2041821389, https://openalex.org/W6743960067, https://openalex.org/W2262522273, https://openalex.org/W2585253307, https://openalex.org/W2051826441, https://openalex.org/W2904554869, https://openalex.org/W2801520690, https://openalex.org/W2024818970, https://openalex.org/W2160080603, https://openalex.org/W2064982295, https://openalex.org/W2958914275, https://openalex.org/W3005531628, https://openalex.org/W2042708317, https://openalex.org/W2965528058, https://openalex.org/W2090355570, https://openalex.org/W2049835164, https://openalex.org/W2604744156, https://openalex.org/W2765807415, https://openalex.org/W2525816848, https://openalex.org/W2803813199, https://openalex.org/W1894201636, https://openalex.org/W2951707357, https://openalex.org/W2096415817, https://openalex.org/W2067068642, https://openalex.org/W2015219390, https://openalex.org/W1988098314, https://openalex.org/W1963829459, https://openalex.org/W2076945264, https://openalex.org/W2899070571, https://openalex.org/W2131363279, https://openalex.org/W3026636373, https://openalex.org/W2999331646, https://openalex.org/W2016941039, https://openalex.org/W2753583923, https://openalex.org/W2944955548 |
| referenced_works_count | 61 |
| abstract_inverted_index.a | 5, 38 |
| abstract_inverted_index.25 | 136 |
| abstract_inverted_index.MM | 67, 76, 82, 93, 106, 179 |
| abstract_inverted_index.To | 49 |
| abstract_inverted_index.an | 132 |
| abstract_inverted_index.by | 140 |
| abstract_inverted_index.in | 88, 96, 165 |
| abstract_inverted_index.is | 9 |
| abstract_inverted_index.of | 18, 46, 53, 84, 104, 108, 135, 151, 163, 189 |
| abstract_inverted_index.on | 20, 64 |
| abstract_inverted_index.to | 29, 122, 148, 175 |
| abstract_inverted_index.we | 59 |
| abstract_inverted_index.Our | 114 |
| abstract_inverted_index.and | 34, 91, 99, 111, 129, 131, 142, 153, 191 |
| abstract_inverted_index.for | 36 |
| abstract_inverted_index.may | 27 |
| abstract_inverted_index.new | 173 |
| abstract_inverted_index.rat | 81, 141, 155 |
| abstract_inverted_index.set | 134 |
| abstract_inverted_index.the | 15, 44, 109, 123, 146, 160, 166, 187 |
| abstract_inverted_index.too | 12 |
| abstract_inverted_index.two | 74 |
| abstract_inverted_index.(MM) | 2 |
| abstract_inverted_index.Data | 69 |
| abstract_inverted_index.SBP1 | 164 |
| abstract_inverted_index.bias | 54 |
| abstract_inverted_index.cell | 77, 157 |
| abstract_inverted_index.data | 147 |
| abstract_inverted_index.from | 43, 73, 80, 101 |
| abstract_inverted_index.poor | 182 |
| abstract_inverted_index.rats | 90 |
| abstract_inverted_index.role | 162 |
| abstract_inverted_index.such | 57 |
| abstract_inverted_index.task | 39 |
| abstract_inverted_index.that | 8, 40 |
| abstract_inverted_index.were | 70 |
| abstract_inverted_index.when | 55 |
| abstract_inverted_index.with | 181 |
| abstract_inverted_index.CAPG, | 127 |
| abstract_inverted_index.These | 169 |
| abstract_inverted_index.could | 41, 171 |
| abstract_inverted_index.early | 31 |
| abstract_inverted_index.grown | 87, 95 |
| abstract_inverted_index.human | 75, 92 |
| abstract_inverted_index.late, | 13 |
| abstract_inverted_index.limit | 50 |
| abstract_inverted_index.lines | 158 |
| abstract_inverted_index.major | 118 |
| abstract_inverted_index.mice, | 98 |
| abstract_inverted_index.often | 10 |
| abstract_inverted_index.still | 3 |
| abstract_inverted_index.three | 65, 117, 124 |
| abstract_inverted_index.tumor | 125 |
| abstract_inverted_index.while | 14 |
| abstract_inverted_index.FABP4, | 128 |
| abstract_inverted_index.LAMB2, | 130 |
| abstract_inverted_index.common | 121 |
| abstract_inverted_index.effect | 17 |
| abstract_inverted_index.future | 192 |
| abstract_inverted_index.highly | 177 |
| abstract_inverted_index.lines, | 78 |
| abstract_inverted_index.shared | 139 |
| abstract_inverted_index.tumors | 83, 94, 107 |
| abstract_inverted_index.benefit | 42 |
| abstract_inverted_index.current | 16, 190 |
| abstract_inverted_index.disease | 7 |
| abstract_inverted_index.firstly | 72 |
| abstract_inverted_index.patient | 21, 105, 143 |
| abstract_inverted_index.provide | 172 |
| abstract_inverted_index.remains | 23 |
| abstract_inverted_index.sources | 52 |
| abstract_inverted_index.success | 188 |
| abstract_inverted_index.thereby | 185 |
| abstract_inverted_index.thirdly | 100 |
| abstract_inverted_index.tumors. | 144 |
| abstract_inverted_index.analyzes | 63, 150 |
| abstract_inverted_index.detected | 11 |
| abstract_inverted_index.identify | 176 |
| abstract_inverted_index.outcomes | 22 |
| abstract_inverted_index.patients | 180 |
| abstract_inverted_index.process. | 168 |
| abstract_inverted_index.revealed | 159 |
| abstract_inverted_index.secondly | 79 |
| abstract_inverted_index.sections | 103 |
| abstract_inverted_index.sources, | 126 |
| abstract_inverted_index.sources. | 68 |
| abstract_inverted_index.survival | 183 |
| abstract_inverted_index.Comparing | 145 |
| abstract_inverted_index.Malignant | 0 |
| abstract_inverted_index.candidate | 137 |
| abstract_inverted_index.collected | 71 |
| abstract_inverted_index.conducted | 60 |
| abstract_inverted_index.different | 66 |
| abstract_inverted_index.improving | 30, 186 |
| abstract_inverted_index.outcomes, | 184 |
| abstract_inverted_index.patients, | 37 |
| abstract_inverted_index.potential | 51 |
| abstract_inverted_index.proteomic | 62, 149 |
| abstract_inverted_index.subtypes. | 113 |
| abstract_inverted_index.therapies | 19 |
| abstract_inverted_index.treatment | 35 |
| abstract_inverted_index.additional | 133, 161 |
| abstract_inverted_index.biomarkers | 26, 120, 138 |
| abstract_inverted_index.contribute | 28 |
| abstract_inverted_index.diagnosis, | 32 |
| abstract_inverted_index.identified | 116 |
| abstract_inverted_index.increasing | 85 |
| abstract_inverted_index.neoplastic | 154 |
| abstract_inverted_index.prognosis, | 33 |
| abstract_inverted_index.represents | 4 |
| abstract_inverted_index.vulnerable | 178 |
| abstract_inverted_index.biomarkers, | 58 |
| abstract_inverted_index.devastating | 6 |
| abstract_inverted_index.development | 45 |
| abstract_inverted_index.epithelioid | 110 |
| abstract_inverted_index.identifying | 56 |
| abstract_inverted_index.mesothelial | 156 |
| abstract_inverted_index.proteomics. | 48 |
| abstract_inverted_index.sarcomatoid | 112 |
| abstract_inverted_index.strategies. | 194 |
| abstract_inverted_index.therapeutic | 193 |
| abstract_inverted_index.Invasiveness | 25 |
| abstract_inverted_index.carcinogenic | 167 |
| abstract_inverted_index.invasiveness | 86, 119 |
| abstract_inverted_index.mesothelioma | 1 |
| abstract_inverted_index.observations | 170 |
| abstract_inverted_index.cross-species | 61 |
| abstract_inverted_index.opportunities | 174 |
| abstract_inverted_index.preneoplastic | 152 |
| abstract_inverted_index.investigations | 115 |
| abstract_inverted_index.high-throughput | 47 |
| abstract_inverted_index.immunocompetent | 89 |
| abstract_inverted_index.immunodeficient | 97 |
| abstract_inverted_index.unsatisfactory. | 24 |
| abstract_inverted_index.paraffin-embedded | 102 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5084555157 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I154526488, https://openalex.org/I49451733 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.88863429 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |