CTNI-42. NAVIGATED FOCUSED ULTRASOUND COMBINED WITH RADIOTHERAPY FOR MALIGNANT GLIOMA: A PILOT CLINICAL STUDY Article Swipe

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Ya-Jui Lin , Ko-Ting Chn , Chiung-Yin Huang , Kuo Chen Wei ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1093/neuonc/noaf201.0538

INTRODUCTION Blood–brain barrier (BBB) remains to be the major obstacle to conquer in treating patients with malignant glioma. Hypoxic tumor microenvironment impaired the effect of radiation induced cell death by Radiation therapy (RT). Focused ultrasound (FUS) combined with systemic microbubbles has been shown not only to open BBB but also potentially increased regional perfusion in preclinical study. However, no clinical study has investigated the combination of RT with FUS-BBB opening (RT-FUS). METHODS We aimed to report a 1-yr analysis of a single arm, prospective, pilot study (NCT04988750) of combining RT-FUS for recurrent high grade glioma patients, of whom re-RT was considered for disease focal control. In both preclinical and clinical studies, FUS-BBB opening protocol was conducted within 2 h before RT. Treatment responses were evaluated by objective response rate (ORR) using magnetic resonance imaging, progression free survival, and overall survival, and adverse events (AE) in clinical study. RESULTS In the pilot clinical trial, enrolled 7 recurrent high grade glioma patients who underwent a total of 24 RT-FUS treatments was presented. Three patients had rapid disease progression at a mean of 33 days after RT-FUS, while another three patients had at least stable disease (mean 323 days) after RT-FUS with or without salvage chemotherapy or target therapy. One patient had partial response after RT-FUS, making the ORR of 16.7%. There was no FUS-related AEs, but one (16.7%) re-RT-related grade three radiation necrosis. CONCLUSION Reirradiation is becoming an option after disease recurrence for both primary and secondary malignant brain tumors since systemic therapy significantly prolongs survival in cancer patients. The mechanism behind the synergistic effect of RT-FUS in preclinical model needs further study. The clinical evidence from the pilot clinical trial (NCT04988750) showed a combination of RT-FUS was safe (no FUS-related adverse effect) and a possible synergic effect.

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Medicine Radiation therapy Clinical study Radiology Progressive disease Clinical trial Magnetic resonance imaging Chemotherapy Adverse effect Glioma Focused ultrasound Disease Ultrasound Microbubbles Complete response Oncology Surgery Stage (stratigraphy) Tumor progression Phases of clinical research Perfusion Nuclear medicine High-intensity focused ultrasound Internal medicine Clinical research

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Type: article
Language: en
Landing Page: https://doi.org/10.1093/neuonc/noaf201.0538
PDF: https://academic.oup.com/neuro-oncology/article-pdf/27/Supplement_5/v135/65255230/noaf201.0538.pdf
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DOI: https://doi.org/10.1093/neuonc/noaf201.0538

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Title: CTNI-42. NAVIGATED FOCUSED ULTRASOUND COMBINED WITH RADIOTHERAPY FOR MALIGNANT GLIOMA: A PILOT CLINICAL STUDY

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Language: en

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Publication year: 2025

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Publication date: 2025-11-01

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Authors: Ya-Jui Lin, Ko-Ting Chn, Chiung-Yin Huang, Kuo Chen Wei

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Landing page: https://doi.org/10.1093/neuonc/noaf201.0538

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Concepts: Medicine, Radiation therapy, Clinical study, Radiology, Progressive disease, Clinical trial, Magnetic resonance imaging, Chemotherapy, Adverse effect, Glioma, Focused ultrasound, Disease, Ultrasound, Microbubbles, Complete response, Oncology, Surgery, Stage (stratigraphy), Tumor progression, Phases of clinical research, Perfusion, Nuclear medicine, High-intensity focused ultrasound, Internal medicine, Clinical research

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abstract_inverted_index.RT-FUS	90, 167, 198, 265, 285
abstract_inverted_index.before	120
abstract_inverted_index.behind	260
abstract_inverted_index.cancer	256
abstract_inverted_index.effect	24, 263
abstract_inverted_index.events	143
abstract_inverted_index.glioma	95, 159
abstract_inverted_index.making	214
abstract_inverted_index.option	237
abstract_inverted_index.report	76
abstract_inverted_index.showed	281
abstract_inverted_index.single	82
abstract_inverted_index.stable	192
abstract_inverted_index.study.	57, 147, 271
abstract_inverted_index.target	205
abstract_inverted_index.trial,	153
abstract_inverted_index.tumors	248
abstract_inverted_index.within	117
abstract_inverted_index.(16.7%)	226
abstract_inverted_index.FUS-BBB	69, 112
abstract_inverted_index.Focused	34
abstract_inverted_index.Hypoxic	19
abstract_inverted_index.METHODS	72
abstract_inverted_index.RESULTS	148
abstract_inverted_index.RT-FUS,	184, 213
abstract_inverted_index.adverse	142, 290
abstract_inverted_index.another	186
abstract_inverted_index.barrier	3
abstract_inverted_index.conquer	12
abstract_inverted_index.disease	103, 175, 193, 239
abstract_inverted_index.effect)	291
abstract_inverted_index.effect.	296
abstract_inverted_index.further	270
abstract_inverted_index.glioma.	18
abstract_inverted_index.induced	27
abstract_inverted_index.opening	70, 113
abstract_inverted_index.overall	139
abstract_inverted_index.partial	210
abstract_inverted_index.patient	208
abstract_inverted_index.primary	243
abstract_inverted_index.remains	5
abstract_inverted_index.salvage	202
abstract_inverted_index.therapy	32, 251
abstract_inverted_index.without	201
abstract_inverted_index.Abstract	0
abstract_inverted_index.However,	58
abstract_inverted_index.analysis	79
abstract_inverted_index.becoming	235
abstract_inverted_index.clinical	60, 110, 146, 152, 273, 278
abstract_inverted_index.combined	37
abstract_inverted_index.control.	105
abstract_inverted_index.enrolled	154
abstract_inverted_index.evidence	274
abstract_inverted_index.imaging,	134
abstract_inverted_index.impaired	22
abstract_inverted_index.magnetic	132
abstract_inverted_index.obstacle	10
abstract_inverted_index.patients	15, 160, 172, 188
abstract_inverted_index.possible	294
abstract_inverted_index.prolongs	253
abstract_inverted_index.protocol	114
abstract_inverted_index.regional	53
abstract_inverted_index.response	128, 211
abstract_inverted_index.studies,	111
abstract_inverted_index.survival	254
abstract_inverted_index.synergic	295
abstract_inverted_index.systemic	39, 250
abstract_inverted_index.therapy.	206
abstract_inverted_index.treating	14
abstract_inverted_index.(RT-FUS).	71
abstract_inverted_index.Radiation	31
abstract_inverted_index.Treatment	122
abstract_inverted_index.combining	89
abstract_inverted_index.conducted	116
abstract_inverted_index.evaluated	125
abstract_inverted_index.increased	52
abstract_inverted_index.malignant	17, 246
abstract_inverted_index.mechanism	259
abstract_inverted_index.necrosis.	231
abstract_inverted_index.objective	127
abstract_inverted_index.patients,	96
abstract_inverted_index.patients.	257
abstract_inverted_index.perfusion	54
abstract_inverted_index.radiation	26, 230
abstract_inverted_index.recurrent	92, 156
abstract_inverted_index.resonance	133
abstract_inverted_index.responses	123
abstract_inverted_index.secondary	245
abstract_inverted_index.survival,	137, 140
abstract_inverted_index.underwent	162
abstract_inverted_index.CONCLUSION	232
abstract_inverted_index.considered	101
abstract_inverted_index.presented.	170
abstract_inverted_index.recurrence	240
abstract_inverted_index.treatments	168
abstract_inverted_index.ultrasound	35
abstract_inverted_index.FUS-related	222, 289
abstract_inverted_index.combination	65, 283
abstract_inverted_index.potentially	51
abstract_inverted_index.preclinical	56, 108, 267
abstract_inverted_index.progression	135, 176
abstract_inverted_index.synergistic	262
abstract_inverted_index.INTRODUCTION	1
abstract_inverted_index.chemotherapy	203
abstract_inverted_index.investigated	63
abstract_inverted_index.microbubbles	40
abstract_inverted_index.prospective,	84
abstract_inverted_index.(NCT04988750)	87, 280
abstract_inverted_index.Blood–brain	2
abstract_inverted_index.Reirradiation	233
abstract_inverted_index.re-RT-related	227
abstract_inverted_index.significantly	252
abstract_inverted_index.microenvironment	21
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	4
citation_normalized_percentile.value	0.70657288
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False