Culture-Negative Native Vertebral Osteomyelitis: A Narrative Review of an Underdescribed Condition Article Swipe
Seyed Mohammad Amin Alavi
,
Francesco Petri
,
Omar Mahmoud
,
Rita Igwilo-Alaneme
,
Said El Zein
,
Ahmad Nassr
,
Andrea Gori
,
Elie F. Berbari
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jcm13195802
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jcm13195802
The incidence of culture-negative NVO (CN-NVO) cases is increasing, presenting significant diagnostic and therapeutic challenges due to the inability to isolate causative organisms with conventional microbiological methods. Factors influencing the diagnosis of CN-NVO include prior antimicrobial therapy, low pathogen burden, fastidious or intracellular organisms, technical issues, and non-infectious mimickers. Diagnosis often relies on imaging modalities like magnetic resonance imaging (MRI) and computed tomography (CT)-guided biopsy, though these methods can sometimes fail to yield positive microbiological results. Advanced diagnostic tools, such as polymerase chain reaction (PCR), metagenomic next-generation sequencing (mNGS), and cell-free DNA analysis, may be necessary to identify the pathogen. The causative pathogen cannot be isolated in some patients, among which an empirical antimicrobial therapy should be initiated. This narrative review discusses the management, monitoring, surgical indications, and outcomes for patients with CN-NVO.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm13195802
- OA Status
- gold
- Cited By
- 6
- References
- 134
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402989106
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402989106Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm13195802Digital Object Identifier
- Title
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Culture-Negative Native Vertebral Osteomyelitis: A Narrative Review of an Underdescribed ConditionWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-28Full publication date if available
- Authors
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Seyed Mohammad Amin Alavi, Francesco Petri, Omar Mahmoud, Rita Igwilo-Alaneme, Said El Zein, Ahmad Nassr, Andrea Gori, Elie F. BerbariList of authors in order
- Landing page
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https://doi.org/10.3390/jcm13195802Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/jcm13195802Direct OA link when available
- Concepts
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Fastidious organism, Medicine, Vertebral osteomyelitis, Magnetic resonance imaging, Antimicrobial, Osteomyelitis, Pathogen, Narrative review, Intensive care medicine, Radiology, Surgery, Microbiology, Bacteria, Immunology, Genetics, BiologyTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 4, 2024: 2Per-year citation counts (last 5 years)
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134Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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