Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice Article Swipe
Yi‐Han Chiu
,
Wei-Ling Chou
,
Mei‐Lan Ko
,
James C. Liao
,
Tse‐Hung Huang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jnutbio.2025.109920
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jnutbio.2025.109920
Curcumin, recognized for its antioxidant and anti-inflammatory properties, is a promising dietary supplement for liver protection. However, its role in preventing obesity-induced hepatic steatosis is not fully understood. This study aims to show that curcumin mitigates hepatic steatosis and promotes browning and thermogenesis in white adipose tissue (WAT) under obesity. Male C57BL/6 mice were assigned to four groups: standard diet (STD), STD supplemented with 100 mg/kg curcumin, high-fat diet (HFD), or HFD supplemented with 100 mg/kg curcumin, administered for 4 weeks. Compared to STD mice, HFD-fed mice exhibited significantly greater body weight, epididymal fat mass, liver weight, postprandial blood glucose (PBG), insulin, and plasma/hepatic alanine aminotransferase (ALT) and triglyceride (TG) levels, alongside an inflammatory response and macrophage infiltration. Additionally, HFD-fed mice showed reduced adiponectin, adiponectin receptor-1, and PI3K/AKT phosphorylation in liver tissue. Except for liver weight, these effects were reversed in curcumin-treated HFD mice. Curcumin inhibited adipocyte hypertrophy and elevated the expression of PGC-1α, PPARγ, and UCP-1 proteins, as well as Zic1, Prdm16, Tnfrsf9, and Tmem26 genes in epididymal fat pads (EFPs). It also significantly altered gut microbiota composition, reducing pro-inflammatory bacteria such as Helicobacter, Oscillospira, Parabacteroides, and Alistipes, thereby alleviating intestinal dysbiosis and improving obesity-related metabolic parameters. In conclusion, curcumin's protective effects against hepatic steatosis and adiposity in HFD-fed mice stem from its ability to upregulate adiponectin, enhance insulin signaling, promote WAT browning, increase thermogenesis, and modulate intestinal dysbiosis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jnutbio.2025.109920
- OA Status
- hybrid
- Cited By
- 7
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409464435
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409464435Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.jnutbio.2025.109920Digital Object Identifier
- Title
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Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed miceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-15Full publication date if available
- Authors
-
Yi‐Han Chiu, Wei-Ling Chou, Mei‐Lan Ko, James C. Liao, Tse‐Hung HuangList of authors in order
- Landing page
-
https://doi.org/10.1016/j.jnutbio.2025.109920Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jnutbio.2025.109920Direct OA link when available
- Concepts
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White adipose tissue, Thermogenesis, Steatosis, Browning, Endocrinology, Obesity, Internal medicine, Adipose tissue, Curcumin, Brown adipose tissue, Liver steatosis, Medicine, Biology, Fatty liver, Food science, Pharmacology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 7Per-year citation counts (last 5 years)
- References (count)
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75Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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