Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancer Article Swipe
Qin Hu
,
Gujie Wu
,
Runtian Wang
,
Huiyun Ma
,
Zhouwei Zhang
,
Qun Xue
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.1007812
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.1007812
Lung cancer is a disease with remarkable heterogeneity. A deep understanding of the tumor microenvironment (TME) offers potential therapeutic strategies against this malignant disease. More and more attention has been paid to the roles of macrophages in the TME. This article briefly summarizes the origin of macrophages, the mutual regulation between anti-tumoral immunity and pro-tumoral statuses derived from macrophage polarization, and the therapeutic opportunities targeting alternately activated macrophages (AAM)-type macrophage polarization. Among them, cellular components including T cells, as well as acellular components represented by IL-4 and IL-13 are key regulators driving the polarization of AAM macrophages. Novel treatments targeting macrophage-associated mechanisms are mainly divided into small molecule inhibitors, monoclonal antibodies, and other therapies to re-acclimate AMM macrophages. Finally, we paid special attention to an immunosuppressive subgroup of macrophages with T cell immunoglobulin and mucin domain-3 (TIM-3) expression. Based on cellular interactions with cancer cells, TIM3+ macrophages facilitate the proliferation and progression of cancer cells, yet this process exposes targets blocking the ligand-receptor recognition. To sum up, this is a systematic review on the mechanism of tumor-associated macrophages (TAM) polarization, therapeutic strategies and the biological functions of Tim-3 positive macrophages that aims to provide new insights into the pathogenesis and treatment of lung cancer.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2022.1007812
- https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007812/pdf
- OA Status
- gold
- Cited By
- 30
- References
- 120
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4308126006
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4308126006Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2022.1007812Digital Object Identifier
- Title
-
Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancerWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-02Full publication date if available
- Authors
-
Qin Hu, Gujie Wu, Runtian Wang, Huiyun Ma, Zhouwei Zhang, Qun XueList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2022.1007812Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007812/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007812/pdfDirect OA link when available
- Concepts
-
Macrophage polarization, Tumor microenvironment, Macrophage, Cancer research, Lung cancer, Immune system, Immunology, Monoclonal antibody, Cancer, Cancer cell, Biology, Antibody, Medicine, Pathology, In vitro, Internal medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 14, 2023: 10Per-year citation counts (last 5 years)
- References (count)
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120Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.article | 40 |
| abstract_inverted_index.between | 50 |
| abstract_inverted_index.briefly | 41 |
| abstract_inverted_index.cancer. | 203 |
| abstract_inverted_index.derived | 56 |
| abstract_inverted_index.disease | 4 |
| abstract_inverted_index.divided | 104 |
| abstract_inverted_index.driving | 91 |
| abstract_inverted_index.exposes | 158 |
| abstract_inverted_index.process | 157 |
| abstract_inverted_index.provide | 193 |
| abstract_inverted_index.special | 121 |
| abstract_inverted_index.targets | 159 |
| abstract_inverted_index.Finally, | 118 |
| abstract_inverted_index.blocking | 160 |
| abstract_inverted_index.cellular | 73, 140 |
| abstract_inverted_index.disease. | 23 |
| abstract_inverted_index.domain-3 | 135 |
| abstract_inverted_index.immunity | 52 |
| abstract_inverted_index.insights | 195 |
| abstract_inverted_index.molecule | 107 |
| abstract_inverted_index.positive | 188 |
| abstract_inverted_index.statuses | 55 |
| abstract_inverted_index.subgroup | 126 |
| abstract_inverted_index.acellular | 81 |
| abstract_inverted_index.activated | 66 |
| abstract_inverted_index.attention | 27, 122 |
| abstract_inverted_index.functions | 185 |
| abstract_inverted_index.including | 75 |
| abstract_inverted_index.malignant | 22 |
| abstract_inverted_index.mechanism | 174 |
| abstract_inverted_index.potential | 17 |
| abstract_inverted_index.targeting | 64, 99 |
| abstract_inverted_index.therapies | 113 |
| abstract_inverted_index.treatment | 200 |
| abstract_inverted_index.(AAM)-type | 68 |
| abstract_inverted_index.biological | 184 |
| abstract_inverted_index.components | 74, 82 |
| abstract_inverted_index.facilitate | 147 |
| abstract_inverted_index.macrophage | 58, 69 |
| abstract_inverted_index.mechanisms | 101 |
| abstract_inverted_index.monoclonal | 109 |
| abstract_inverted_index.regulation | 49 |
| abstract_inverted_index.regulators | 90 |
| abstract_inverted_index.remarkable | 6 |
| abstract_inverted_index.strategies | 19, 181 |
| abstract_inverted_index.summarizes | 42 |
| abstract_inverted_index.systematic | 170 |
| abstract_inverted_index.treatments | 98 |
| abstract_inverted_index.alternately | 65 |
| abstract_inverted_index.antibodies, | 110 |
| abstract_inverted_index.expression. | 137 |
| abstract_inverted_index.inhibitors, | 108 |
| abstract_inverted_index.macrophages | 35, 67, 128, 146, 177, 189 |
| abstract_inverted_index.pro-tumoral | 54 |
| abstract_inverted_index.progression | 151 |
| abstract_inverted_index.represented | 83 |
| abstract_inverted_index.therapeutic | 18, 62, 180 |
| abstract_inverted_index.anti-tumoral | 51 |
| abstract_inverted_index.interactions | 141 |
| abstract_inverted_index.macrophages, | 46 |
| abstract_inverted_index.macrophages. | 96, 117 |
| abstract_inverted_index.pathogenesis | 198 |
| abstract_inverted_index.polarization | 93 |
| abstract_inverted_index.re-acclimate | 115 |
| abstract_inverted_index.recognition. | 163 |
| abstract_inverted_index.opportunities | 63 |
| abstract_inverted_index.polarization, | 59, 179 |
| abstract_inverted_index.polarization. | 70 |
| abstract_inverted_index.proliferation | 149 |
| abstract_inverted_index.understanding | 10 |
| abstract_inverted_index.heterogeneity. | 7 |
| abstract_inverted_index.immunoglobulin | 132 |
| abstract_inverted_index.ligand-receptor | 162 |
| abstract_inverted_index.microenvironment | 14 |
| abstract_inverted_index.tumor-associated | 176 |
| abstract_inverted_index.immunosuppressive | 125 |
| abstract_inverted_index.macrophage-associated | 100 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5086762809 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I199305430, https://openalex.org/I4210086801 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91478575 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |