Cyclic vomiting and digestive symptoms in White–Sutton syndrome: a participatory study Article Swipe
Catherine Cormier
,
André Lefèvre
,
R. Maudinas
,
Maxime Gonnot
,
Aurore Garde
,
Caroline Racine
,
Marlène Malbos
,
Jeanne Amiel
,
Emmanuelle Ginglinger
,
Sylvie Odent
,
Laurent Pasquier
,
Christine Coubes
,
Roseline Caumes
,
Aline Vincent
,
Sophie Julia
,
Mélanie Fradin
,
Elise Brischoux‐Boucher
,
Juliette Piard
,
Annick Toutain
,
Élise Schaefer
,
Pauline Burger
,
Jean‐Louis Mandel
,
Charles-Patrick Edery
,
Karine Jobard-Garou
,
Christel Thauvin-Robinet
,
Frédéric Huet
,
Laurence Faivre
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7065996/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7065996/v1
Background White–Sutton syndrome is a neurodevelopmental condition with a high prevalence of gastrointestinal disorders (89%), including cyclic vomiting (21–37.5%). Our objective was to better characterize repeated vomiting, cyclic vomiting syndrome in particular, and other digestive symptoms by conducting a participatory study. Methods French White–Sutton Association members received a questionnaire to identify and describe repeated vomiting, constipation, feeding difficulties and gastroesophageal reflux. Families or physicians were contacted in the event of missing or unclear answers. Results 34 patients out of 46 participated in our study, of whom 59% presented with digestive symptoms. 35% (12/34) reported repeated vomiting and 9% (3/34) met Rome IV criteria for cyclic vomiting syndrome, with a significant quality of life impact. 35% (12/34) reported constipation (18% – 6/34 meeting Rome IV criteria for functional constipation), 29% (10/34) feeding difficulties and 29% (10/34) symptoms of gastroesophageal reflux disease. In 70% of cases, patients presented with more than one gastrointestinal disorder. Conclusions Our participatory study is the first focusing on gastrointestinal disorders. It allowed us to obtain very precise information about the digestive phenotype and its consequences for patients. Further studies are required to evaluate if a genotype–phenotype correlation exists.
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Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-7065996/v1
- OA Status
- gold
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413166447
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413166447Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-7065996/v1Digital Object Identifier
- Title
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Cyclic vomiting and digestive symptoms in White–Sutton syndrome: a participatory studyWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-13Full publication date if available
- Authors
-
Catherine Cormier, André Lefèvre, R. Maudinas, Maxime Gonnot, Aurore Garde, Caroline Racine, Marlène Malbos, Jeanne Amiel, Emmanuelle Ginglinger, Sylvie Odent, Laurent Pasquier, Christine Coubes, Roseline Caumes, Aline Vincent, Sophie Julia, Mélanie Fradin, Elise Brischoux‐Boucher, Juliette Piard, Annick Toutain, Élise Schaefer, Pauline Burger, Jean‐Louis Mandel, Charles-Patrick Edery, Karine Jobard-Garou, Christel Thauvin-Robinet, Frédéric Huet, Laurence FaivreList of authors in order
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https://doi.org/10.21203/rs.3.rs-7065996/v1Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.21203/rs.3.rs-7065996/v1Direct OA link when available
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Vomiting, White (mutation), Citizen journalism, Medicine, White paper, Psychology, Internal medicine, Gastroenterology, Political science, Biology, Law, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2045981425, https://openalex.org/W3207296638, https://openalex.org/W2989849140, https://openalex.org/W2752524456, https://openalex.org/W2075918530, https://openalex.org/W4223632580, https://openalex.org/W2177815640, https://openalex.org/W2994957825, https://openalex.org/W3096707486, https://openalex.org/W2759029438, https://openalex.org/W4310224722, https://openalex.org/W2466141895, https://openalex.org/W2604393173, https://openalex.org/W2801085490, https://openalex.org/W2182760264, https://openalex.org/W1884507993, https://openalex.org/W2964787551, https://openalex.org/W2231796009, https://openalex.org/W2291183135, https://openalex.org/W2553463105, https://openalex.org/W2611250654, https://openalex.org/W2921944255, https://openalex.org/W3023266236, https://openalex.org/W2946998447, https://openalex.org/W3173698650, https://openalex.org/W3176126106, https://openalex.org/W3108454798, https://openalex.org/W3114003549, https://openalex.org/W3159391580, https://openalex.org/W4362555687, https://openalex.org/W4223594631, https://openalex.org/W4283811378, https://openalex.org/W2022823966, https://openalex.org/W2120328964, https://openalex.org/W2811077273, https://openalex.org/W3014608586, https://openalex.org/W4321609996, https://openalex.org/W4399459465, https://openalex.org/W2895935606, https://openalex.org/W2600775561, https://openalex.org/W1994624010, https://openalex.org/W3133881058, https://openalex.org/W2097982447, https://openalex.org/W2024676323, https://openalex.org/W4296782399, https://openalex.org/W2089095676, https://openalex.org/W4205367823 |
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| abstract_inverted_index.cases, | 144 |
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| abstract_inverted_index.study, | 84 |
| abstract_inverted_index.study. | 41 |
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| abstract_inverted_index.(12/34) | 93, 116 |
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| abstract_inverted_index.Results | 75 |
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| abstract_inverted_index.exists. | 191 |
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