Cytochrome P450 in GtoPdb v.2023.1 Article Swipe
Kathryn Burns
,
Nuala A. Helsby
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.2218/gtopdb/f242/2023.1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.2218/gtopdb/f242/2023.1
The cytochrome P450 enzyme superfamily (CYP), E.C. 1.14.-.-, are haem-containing monooxygenases with a vast range of both endogenous and exogenous substrates. These include sterols, fatty acids, eicosanoids, fat-soluble vitamins, hormones, pesticides and carcinogens as well as drugs. Listed below are the human enzymes, their relationship with rodent CYP enzyme activities is obscure in that the species orthologue may not metabolise the same substrates. Some of the CYP enzymes located in the liver are particularly important for drug metabolism, both hepatic and extrahepatic CYP enzymes also contribute to patho/physiological processes. Genetic variation of CYP isoforms is widespread and likely underlies a proportion of individual variation in drug disposition. The superfamily has the root symbol CYP, followed by a number to indicate the family, a capital letter for the subfamily with a numeral for the individual enzyme. Some CYP are able to metabolise multiple substrates, others are oligo- or mono- specific. CYP also catalyse diverse oxidation and reduction reactions. These include ring hydroxylation, N-oxidation, sulfoxidation, epoxidation, the dealkylation of N-, S- and O- moieties, desulfation, deamination, as well as reduction of azo, nitro and N-oxide groups.
Related Topics
Concepts
Cytochrome P450
Monooxygenase
Enzyme
Biochemistry
Hydroxylation
Biology
Isozyme
Reductase
Drug metabolism
Metabolism
CYP2C9
Cytochrome
Chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2218/gtopdb/f242/2023.1
- http://journals.ed.ac.uk/gtopdb-cite/article/download/8761/11678
- OA Status
- diamond
- Cited By
- 7
- References
- 115
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4382202511Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2218/gtopdb/f242/2023.1Digital Object Identifier
- Title
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Cytochrome P450 in GtoPdb v.2023.1Work title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-04-26Full publication date if available
- Authors
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Kathryn Burns, Nuala A. HelsbyList of authors in order
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https://doi.org/10.2218/gtopdb/f242/2023.1Publisher landing page
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https://journals.ed.ac.uk/gtopdb-cite/article/download/8761/11678Direct link to full text PDF
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diamondOpen access status per OpenAlex
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https://journals.ed.ac.uk/gtopdb-cite/article/download/8761/11678Direct OA link when available
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Cytochrome P450, Monooxygenase, Enzyme, Biochemistry, Hydroxylation, Biology, Isozyme, Reductase, Drug metabolism, Metabolism, CYP2C9, Cytochrome, ChemistryTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 1, 2024: 5, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.a | 12, 99, 116, 122, 129 |
| abstract_inverted_index.O- | 170 |
| abstract_inverted_index.S- | 168 |
| abstract_inverted_index.as | 33, 35, 174, 176 |
| abstract_inverted_index.by | 115 |
| abstract_inverted_index.in | 52, 69, 104 |
| abstract_inverted_index.is | 50, 94 |
| abstract_inverted_index.of | 15, 64, 91, 101, 166, 178 |
| abstract_inverted_index.or | 146 |
| abstract_inverted_index.to | 86, 118, 139 |
| abstract_inverted_index.CYP | 47, 66, 82, 92, 136, 149 |
| abstract_inverted_index.N-, | 167 |
| abstract_inverted_index.The | 0, 107 |
| abstract_inverted_index.and | 18, 31, 80, 96, 154, 169, 181 |
| abstract_inverted_index.are | 8, 39, 72, 137, 144 |
| abstract_inverted_index.for | 75, 125, 131 |
| abstract_inverted_index.has | 109 |
| abstract_inverted_index.may | 57 |
| abstract_inverted_index.not | 58 |
| abstract_inverted_index.the | 40, 54, 60, 65, 70, 110, 120, 126, 132, 164 |
| abstract_inverted_index.CYP, | 113 |
| abstract_inverted_index.E.C. | 6 |
| abstract_inverted_index.P450 | 2 |
| abstract_inverted_index.Some | 63, 135 |
| abstract_inverted_index.able | 138 |
| abstract_inverted_index.also | 84, 150 |
| abstract_inverted_index.azo, | 179 |
| abstract_inverted_index.both | 16, 78 |
| abstract_inverted_index.drug | 76, 105 |
| abstract_inverted_index.ring | 159 |
| abstract_inverted_index.root | 111 |
| abstract_inverted_index.same | 61 |
| abstract_inverted_index.that | 53 |
| abstract_inverted_index.vast | 13 |
| abstract_inverted_index.well | 34, 175 |
| abstract_inverted_index.with | 11, 45, 128 |
| abstract_inverted_index.These | 21, 157 |
| abstract_inverted_index.below | 38 |
| abstract_inverted_index.fatty | 24 |
| abstract_inverted_index.human | 41 |
| abstract_inverted_index.liver | 71 |
| abstract_inverted_index.mono- | 147 |
| abstract_inverted_index.nitro | 180 |
| abstract_inverted_index.range | 14 |
| abstract_inverted_index.their | 43 |
| abstract_inverted_index.(CYP), | 5 |
| abstract_inverted_index.Listed | 37 |
| abstract_inverted_index.acids, | 25 |
| abstract_inverted_index.drugs. | 36 |
| abstract_inverted_index.enzyme | 3, 48 |
| abstract_inverted_index.letter | 124 |
| abstract_inverted_index.likely | 97 |
| abstract_inverted_index.number | 117 |
| abstract_inverted_index.oligo- | 145 |
| abstract_inverted_index.others | 143 |
| abstract_inverted_index.rodent | 46 |
| abstract_inverted_index.symbol | 112 |
| abstract_inverted_index.Genetic | 89 |
| abstract_inverted_index.N-oxide | 182 |
| abstract_inverted_index.capital | 123 |
| abstract_inverted_index.diverse | 152 |
| abstract_inverted_index.enzyme. | 134 |
| abstract_inverted_index.enzymes | 67, 83 |
| abstract_inverted_index.family, | 121 |
| abstract_inverted_index.groups. | 183 |
| abstract_inverted_index.hepatic | 79 |
| abstract_inverted_index.include | 22, 158 |
| abstract_inverted_index.located | 68 |
| abstract_inverted_index.numeral | 130 |
| abstract_inverted_index.obscure | 51 |
| abstract_inverted_index.species | 55 |
| abstract_inverted_index.catalyse | 151 |
| abstract_inverted_index.enzymes, | 42 |
| abstract_inverted_index.followed | 114 |
| abstract_inverted_index.indicate | 119 |
| abstract_inverted_index.isoforms | 93 |
| abstract_inverted_index.multiple | 141 |
| abstract_inverted_index.sterols, | 23 |
| abstract_inverted_index.1.14.-.-, | 7 |
| abstract_inverted_index.exogenous | 19 |
| abstract_inverted_index.hormones, | 29 |
| abstract_inverted_index.important | 74 |
| abstract_inverted_index.moieties, | 171 |
| abstract_inverted_index.oxidation | 153 |
| abstract_inverted_index.reduction | 155, 177 |
| abstract_inverted_index.specific. | 148 |
| abstract_inverted_index.subfamily | 127 |
| abstract_inverted_index.underlies | 98 |
| abstract_inverted_index.variation | 90, 103 |
| abstract_inverted_index.vitamins, | 28 |
| abstract_inverted_index.activities | 49 |
| abstract_inverted_index.contribute | 85 |
| abstract_inverted_index.cytochrome | 1 |
| abstract_inverted_index.endogenous | 17 |
| abstract_inverted_index.individual | 102, 133 |
| abstract_inverted_index.metabolise | 59, 140 |
| abstract_inverted_index.orthologue | 56 |
| abstract_inverted_index.pesticides | 30 |
| abstract_inverted_index.processes. | 88 |
| abstract_inverted_index.proportion | 100 |
| abstract_inverted_index.reactions. | 156 |
| abstract_inverted_index.widespread | 95 |
| abstract_inverted_index.carcinogens | 32 |
| abstract_inverted_index.fat-soluble | 27 |
| abstract_inverted_index.metabolism, | 77 |
| abstract_inverted_index.substrates, | 142 |
| abstract_inverted_index.substrates. | 20, 62 |
| abstract_inverted_index.superfamily | 4, 108 |
| abstract_inverted_index.N-oxidation, | 161 |
| abstract_inverted_index.dealkylation | 165 |
| abstract_inverted_index.deamination, | 173 |
| abstract_inverted_index.desulfation, | 172 |
| abstract_inverted_index.disposition. | 106 |
| abstract_inverted_index.eicosanoids, | 26 |
| abstract_inverted_index.epoxidation, | 163 |
| abstract_inverted_index.extrahepatic | 81 |
| abstract_inverted_index.particularly | 73 |
| abstract_inverted_index.relationship | 44 |
| abstract_inverted_index.hydroxylation, | 160 |
| abstract_inverted_index.monooxygenases | 10 |
| abstract_inverted_index.sulfoxidation, | 162 |
| abstract_inverted_index.haem-containing | 9 |
| abstract_inverted_index.patho/physiological | 87 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 2 |
| citation_normalized_percentile.value | 0.96302091 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |