Daily patterns in parasite processes: diel variation in fish louse transcriptomes Article Swipe
R. Howard Hunt
,
Jo Cable
,
Amy Ellison
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijpara.2022.04.001
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijpara.2022.04.001
Parasites, similar to all other organisms, time themselves to environmental cues using a molecular clock to generate and maintain rhythms. Chronotherapeutic (timed treatment) techniques based on such rhythms offer great potential for improving control of chronic, problematic parasites. Fish lice are a key disease threat in aquaculture, with current control insufficient. Assessing the rhythmicity of fish lice transcriptomes offers not only insight into the viability of chronotherapy, but the opportunity to identify new drug targets. Here, for the first known time in any crustacean parasite, diel changes in gene transcription are examined, revealing that approximately half of the Argulus foliaceus annotated transcriptome displays significant daily rhythmicity. We identified rhythmically transcribed putative clock genes including core clock/cycle and period/timeless pairs, alongside rhythms in feeding-associated genes and processes involving immune response, as well as fish louse drug targets. A substantial number of gene pathways showed peak transcription in hours immediately preceding onset of light, potentially in anticipation of peak host anti-parasite responses or in preparation for increased feeding activity. Genes related to immune haemocyte activity and chitin development were more highly transcribed 4 h post light onset, although inflammatory gene transcription was highest during dark periods. Our study provides an important resource for application of chronotherapy in fish lice; timed application could increase efficacy and/or reduce dose requirement, improving the current landscape of drug resistance and fish health while reducing the economic cost of infection.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ijpara.2022.04.001
- OA Status
- hybrid
- Cited By
- 4
- References
- 97
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4229067840Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.ijpara.2022.04.001Digital Object Identifier
- Title
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Daily patterns in parasite processes: diel variation in fish louse transcriptomesWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-06Full publication date if available
- Authors
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R. Howard Hunt, Jo Cable, Amy EllisonList of authors in order
- Landing page
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https://doi.org/10.1016/j.ijpara.2022.04.001Publisher landing page
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.ijpara.2022.04.001Direct OA link when available
- Concepts
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Biology, Chronotherapy (sleep phase), Transcriptome, Poecilia, Parasite hosting, Circadian rhythm, Gene, Diel vertical migration, Louse, Circadian clock, Zoology, Evolutionary biology, Ecology, Genetics, Fish
, Gene expression, Fishery, Neuroscience, Computer science, World Wide Web Top concepts (fields/topics) attached by OpenAlex - Cited by
-
4Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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97Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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