Dapagliflozin/Hesperidin Combination Mitigates Lipopolysaccharide-Induced Alzheimer’s Disease in Rats Article Swipe
Maaly A. Abd Elmaaboud
,
Remon S. Estfanous
,
Aliaa Atef
,
Ahmed M. Kabel
,
Khalid A. Alnemari
,
Tamer Mohamed Naguib
,
Shuruq E. Alsufyani
,
Hany W. Darwish
,
Hany H. Arab
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ph16101370
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ph16101370
Alzheimer’s disease (AD) is the most common form of neurodegenerative disorders worldwide. Its pathologic features include massive neuroinflammation with abnormal deposition of β-amyloid peptide in the cerebral tissues leading to degeneration of the brain neurons. Adverse effects associated with the traditional drugs used for the treatment of this pathological condition have directed the research efforts towards searching for alternative effective agents with minimal adverse effects. The aim of this study was to elucidate the potential ameliorative effects of dapagliflozin and/or hesperidin on Alzheimer’s disease (AD) induced by lipopolysaccharide (LPS) injection in rats. In a rodent model of AD, the effect of dapagliflozin with or without hesperidin on the biochemical parameters and the behavioral tests as well as the histopathological parameters was determined. Each of dapagliflozin and hesperidin restored the behavioral tests to the reference values, augmented the antioxidant defense mechanisms, ameliorated the neuronal inflammatory responses, combatted the changes in Toll-like receptor-4 (TLR-4)/High-mobility group box 1 (HMGB1) protein signaling and receptors of advanced glycation end products (RAGE) levels, and restored the balance between the apoptotic signals and autophagy in the hippocampal tissues. Additionally, both agents exhibited an outstanding ability to combat LPS-induced perturbations in the histopathological and electron microscopic image of the brain tissues. These favorable effects were significantly encountered in the group treated with dapagliflozin/hesperidin combination when compared versus animals treated with either dapagliflozin or hesperidin. In conclusion, inhibition of the hippocampal HMGB1/TLR4/RAGE signaling, the pro-inflammatory axis, and apoptosis alongside augmentation of the antioxidant defenses and autophagy can be regarded as beneficial effects by which dapagliflozin/hesperidin combination may combat LPS-triggered AD.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.3390/ph16101370
- https://www.mdpi.com/1424-8247/16/10/1370/pdf?version=1695822875
- OA Status
- gold
- Cited By
- 29
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387120952
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387120952Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ph16101370Digital Object Identifier
- Title
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Dapagliflozin/Hesperidin Combination Mitigates Lipopolysaccharide-Induced Alzheimer’s Disease in RatsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-09-27Full publication date if available
- Authors
-
Maaly A. Abd Elmaaboud, Remon S. Estfanous, Aliaa Atef, Ahmed M. Kabel, Khalid A. Alnemari, Tamer Mohamed Naguib, Shuruq E. Alsufyani, Hany W. Darwish, Hany H. ArabList of authors in order
- Landing page
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https://doi.org/10.3390/ph16101370Publisher landing page
- PDF URL
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https://www.mdpi.com/1424-8247/16/10/1370/pdf?version=1695822875Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1424-8247/16/10/1370/pdf?version=1695822875Direct OA link when available
- Concepts
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Hesperidin, Medicine, HMGB1, Pharmacology, Autophagy, Rage (emotion), TLR4, Inflammation, Neuroinflammation, Hippocampal formation, Apoptosis, Internal medicine, Pathology, Neuroscience, Chemistry, Biology, Biochemistry, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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29Total citation count in OpenAlex
- Citations by year (recent)
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2025: 19, 2024: 8, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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