Data from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Article Swipe

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Bradley M. Broom , Michael C. Ryan , Robert Brown , Futa Ikeda , Mark Stucky , David W. Kane , James Melott , Chris Wakefield , Tod D. Casasent , Rehan Akbani , John N. Weinstein ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/0008-5472.c.6510119.v2

Clustered heatmaps are the most frequently used graphics for visualization of molecular profiling data in biology. However, they are generally rendered as static, or only modestly interactive, images. We have now used recent advances in web technologies to produce interactive “next-generation” clustered heatmaps (NG-CHM) that enable extreme zooming and navigation without loss of resolution. NG-CHMs also provide link-outs to additional information sources and include other features that facilitate deep exploration of the biology behind the image. Here, we describe an implementation of the NG-CHM system in the Galaxy bioinformatics platform. We illustrate the algorithm and available computational tool using RNA-seq data from The Cancer Genome Atlas program's Kidney Clear Cell Carcinoma project. Cancer Res; 77(21); e23–26. ©2017 AACR.

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Profiling (computer programming) Computer science Galaxy Astrophysics Physics Operating system

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/0008-5472.c.6510119.v2
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DOI: https://doi.org/10.1158/0008-5472.c.6510119.v2

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Title: Data from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data

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Type: preprint

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Language: en

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Publication year: 2024

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Publication date: 2024-07-16

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Authors: Bradley M. Broom, Michael C. Ryan, Robert Brown, Futa Ikeda, Mark Stucky, David W. Kane, James Melott, Chris Wakefield, Tod D. Casasent, Rehan Akbani, John N. Weinstein

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Landing page: https://doi.org/10.1158/0008-5472.c.6510119.v2

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Concepts: Profiling (computer programming), Computer science, Galaxy, Astrophysics, Physics, Operating system

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