Data from Activation of Rap1 Promotes Prostate Cancer Metastasis Article Swipe
Candice L. Bailey
,
Patrick J. Kelly
,
Patrick J. Casey
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/0008-5472.c.6498659.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/0008-5472.c.6498659.v1
Elucidating the mechanisms of prostate cancer (CaP) survival and metastasis are critical to the discovery of novel therapeutic targets. The monomeric G protein Rap1 has been implicated in cancer tumorigenesis. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting Rap1 may promote several processes associated with cancer cell metastasis. Examination of CaP cell lines revealed cells with a high metastatic ability exhibited increased Rap1 activity and reduced expression of the negative regulator Rap1GAP. Rap1 can be further stimulated in these cells by stromal-derived factor (SDF-1), an agonist known to regulate tumor cell metastasis and tropism to bone. Activation of Rap1 increased CaP cell migration and invasion, and inhibition of Rap1A activity via RNAi-mediated knockdown or ectopic expression of Rap1GAP markedly impaired CaP cell migration and invasion. Additional studies implicate integrins α4, β3, and αvβ3 in the mechanism of Rap1-mediated CaP migration and invasion. Extending the effect of Rap1 activity in CaP metastasis in vivo, introduction of activated Rap1 into CaP cells dramatically enhanced the rate and incidence of CaP metastasis in a xenograft mouse model. These studies provide compelling evidence to support a role for aberrant Rap1 activation in CaP progression, and suggest that targeting Rap1 signaling could provide a means to control metastatic progression of this cancer. [Cancer Res 2009;69(12):4962–8]
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Metadata
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All OpenAlex metadata
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https://openalex.org/W4392725114Canonical identifier for this work in OpenAlex
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https://doi.org/10.1158/0008-5472.c.6498659.v1Digital Object Identifier
- Title
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Data from Activation of Rap1 Promotes Prostate Cancer MetastasisWork title
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preprintOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-03-30Full publication date if available
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Candice L. Bailey, Patrick J. Kelly, Patrick J. CaseyList of authors in order
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https://doi.org/10.1158/0008-5472.c.6498659.v1Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1158/0008-5472.c.6498659.v1Direct OA link when available
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Prostate cancer, Rap1, Metastasis, Cancer, Medicine, Cancer metastasis, Prostate, Cancer research, Oncology, Internal medicine, Biology, Cell biology, Signal transductionTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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