Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Article Swipe
Feng Shi
,
Li Shang
,
Bei-Qing Pan
,
Xiaomin Wang
,
Yan‐Yi Jiang
,
Jia‐Jie Hao
,
Yu Zhang
,
Yan Cai
,
Xin Xu
,
Qimin Zhan
,
Ming‐Rong Wang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.c.6523007
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.c.6523007
Purpose: We previously revealed that the calreticulin (CRT) gene is a candidate oncogene promoting cell migration and invasion and that neuropilin-1 (NRP1) is a possible effector downstream of CRT in esophageal squamous carcinoma cells. This study aims to explore the mechanisms underlying the migration and invasion of esophageal cancer cells regulated by CRT through NRP1.Experimental Design: Quantitative reverse-transcription polymerase chain reaction, Western blot analysis, chromatin immunoprecipitation, and reporter gene assays were used to investigate the relationship between CRT and NRP1. In vitro and in vivo assays were carried out to evaluate the effects of NRP1 on malignant phenotypes of ESCC cells and tumor metastasis in NOD/SCID mice. Immunohistochemistry was performed to analyze the expression of CRT and NRP1 in esophageal squamous cell carcinomas (ESCC).Results: Knockdown of CRT decreased the expression of NRP1. Inhibition of NRP1 reduced ESCC cell motility in vitro and experimental metastasis in vivo. Ectopic expression of NRP1 rescued the defects of cell migration and invasion in CRT-shRNA cells. CRT depletion inhibited STAT5A phosphorylation at the Y694 site via a CaMKII-independent pathway. Moreover, STAT5A directly regulated NRP1 transcription. Knockdown of CRT or NRP1 led to a downregulation of MMP2, MMP9, and FAK. Notably, positive correlation was found between CRT and NRP1 expression in ESCC tissues (P = 5.87 × 10−5). CRT and NRP1 coexpression was significantly associated with lymph node metastasis (P = 0.025).Conclusions: Our findings suggest that NRP1 is a critical downstream effector of CRT in promoting cell migration and invasion, which might contribute to the metastasis of ESCC. Clin Cancer Res; 20(23); 6153–62. ©2014 AACR.
Related Topics
Concepts
Cancer research
Gene knockdown
Small hairpin RNA
Cell migration
Ectopic expression
Chromatin immunoprecipitation
Biology
Molecular biology
Chemistry
Cell
Cell culture
Gene expression
Promoter
Gene
Genetics
Biochemistry
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/1078-0432.c.6523007
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4361959458
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4361959458Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1158/1078-0432.c.6523007Digital Object Identifier
- Title
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Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5AWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-03-31Full publication date if available
- Authors
-
Feng Shi, Li Shang, Bei-Qing Pan, Xiaomin Wang, Yan‐Yi Jiang, Jia‐Jie Hao, Yu Zhang, Yan Cai, Xin Xu, Qimin Zhan, Ming‐Rong WangList of authors in order
- Landing page
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https://doi.org/10.1158/1078-0432.c.6523007Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1158/1078-0432.c.6523007Direct OA link when available
- Concepts
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Cancer research, Gene knockdown, Small hairpin RNA, Cell migration, Ectopic expression, Chromatin immunoprecipitation, Biology, Molecular biology, Chemistry, Cell, Cell culture, Gene expression, Promoter, Gene, Genetics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.oncogene | 12 |
| abstract_inverted_index.pathway. | 173 |
| abstract_inverted_index.positive | 195 |
| abstract_inverted_index.possible | 24 |
| abstract_inverted_index.reporter | 67 |
| abstract_inverted_index.revealed | 3 |
| abstract_inverted_index.squamous | 31, 120 |
| abstract_inverted_index.CRT-shRNA | 159 |
| abstract_inverted_index.Knockdown | 124, 180 |
| abstract_inverted_index.Moreover, | 174 |
| abstract_inverted_index.analysis, | 63 |
| abstract_inverted_index.candidate | 11 |
| abstract_inverted_index.carcinoma | 32 |
| abstract_inverted_index.chromatin | 64 |
| abstract_inverted_index.decreased | 127 |
| abstract_inverted_index.depletion | 162 |
| abstract_inverted_index.inhibited | 163 |
| abstract_inverted_index.invasion, | 243 |
| abstract_inverted_index.malignant | 96 |
| abstract_inverted_index.migration | 15, 43, 155, 241 |
| abstract_inverted_index.performed | 109 |
| abstract_inverted_index.promoting | 13, 239 |
| abstract_inverted_index.reaction, | 60 |
| abstract_inverted_index.regulated | 50, 177 |
| abstract_inverted_index.6153–62. | 256 |
| abstract_inverted_index.Inhibition | 132 |
| abstract_inverted_index.associated | 218 |
| abstract_inverted_index.carcinomas | 122 |
| abstract_inverted_index.contribute | 246 |
| abstract_inverted_index.downstream | 26, 234 |
| abstract_inverted_index.esophageal | 30, 47, 119 |
| abstract_inverted_index.expression | 113, 129, 147, 203 |
| abstract_inverted_index.mechanisms | 40 |
| abstract_inverted_index.metastasis | 103, 143, 222, 249 |
| abstract_inverted_index.phenotypes | 97 |
| abstract_inverted_index.polymerase | 58 |
| abstract_inverted_index.previously | 2 |
| abstract_inverted_index.underlying | 41 |
| abstract_inverted_index.<i>In | 80 |
| abstract_inverted_index.<i>in | 83, 139, 144 |
| abstract_inverted_index.correlation | 196 |
| abstract_inverted_index.investigate | 73 |
| abstract_inverted_index.Quantitative | 56 |
| abstract_inverted_index.calreticulin | 6 |
| abstract_inverted_index.coexpression | 215 |
| abstract_inverted_index.experimental | 142 |
| abstract_inverted_index.neuropilin-1 | 20 |
| abstract_inverted_index.relationship | 75 |
| abstract_inverted_index.<i>Clin | 252 |
| abstract_inverted_index.significantly | 217 |
| abstract_inverted_index.downregulation | 188 |
| abstract_inverted_index.transcription. | 179 |
| abstract_inverted_index.vivo</i> | 84 |
| abstract_inverted_index.phosphorylation | 165 |
| abstract_inverted_index.vitro</i> | 81, 140 |
| abstract_inverted_index.vivo</i>. | 145 |
| abstract_inverted_index.Design:</b> | 55 |
| abstract_inverted_index.CaMKII-independent | 172 |
| abstract_inverted_index.Immunohistochemistry | 107 |
| abstract_inverted_index.immunoprecipitation, | 65 |
| abstract_inverted_index.(<i>P</i> | 207, 223 |
| abstract_inverted_index.reverse-transcription | 57 |
| abstract_inverted_index.10<sup>−5</sup>). | 211 |
| abstract_inverted_index.AACR</i>.</p></div> | 258 |
| abstract_inverted_index.NRP1.</p><p><b>Experimental | 54 |
| abstract_inverted_index.(ESCC).</p><p><b>Results:</b> | 123 |
| abstract_inverted_index.<div>Abstract<p><b>Purpose:</b> | 0 |
| abstract_inverted_index.0.025).</p><p><b>Conclusions:</b> | 225 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.12853548 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |