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Data from Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma
April 2023 • Daniela Paňková, Yulong Chen, Masahiko Terajima, Mark J. Schliekelman, Brandi N. Baird, Monica Fahrenholtz, Sun Li, Bartley J. Gill, Tegy J. Vadakkan…
<div>Abstract<p>Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in epithelial tumors. To address this question, we used Kras<sup>LA1</sup> mice, which develop lung adenocarcinomas from somatic activation of a <i>Kras<sup>G12D</sup></i> allele. The lung tumors in Kras<sup>LA1</sup> mice were highly fibrotic and contained cancer-associated fibroblasts (…