Data from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Article Swipe

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Ilona Argirion , Ruth M. Pfeiffer , Carla Proietti , Anna E. Coghill , Kelly J. Yu , Jaap M. Middeldorp , Yomani D. Sarathkumara , Wan‐Lun Hsu , Yin-Chu Chien , Pei‐Jen Lou , Cheng‐Ping Wang , Nathaniel Rothman , Qing Lan , Chien‐Jen Chen , Sam M. Mbulaiteye , Ruth F. Jarrett , Ingrid Glimelius , Karin E. Smedby , Henrik Hjalgrim , Allan Hildesheim , Denise L. Doolan , Zhiwei Liu ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1055-9965.c.6624590

Background:Epstein–Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt lymphoma (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell lymphoma (NKTCL).Methods:Anti-EBV IgG and IgA antibody responses targeting 202 sequences from 86 EBV proteins were measured using the same EBV whole proteome array across four case–control studies investigating EBV-positive cHL, eBL, NPC, and NKTCL (407 cases/620 controls). We grouped EBV-targeted antibodies into pathways by immunoglobulin type (IgA and IgG) and life-cycle stage (latent, immediate early lytic, early lytic, late lytic, and glycoprotein) and evaluated their association with each cancer type. In an additional analysis, we focused on the subset of 46 individual antibodies representing the top candidates for each cancer and compared their associations across the four cancer types using multivariable linear regression models.Results:IgA antibody responses targeting all EBV life-cycle stages were associated with NPC but limited to anti-early lytic stage for cHL. NPC and eBL were associated with IgG antibodies across the viral life cycle; cHL with antibodies in the early lytic, late lytic and glycoprotein stages; and NKTCL with antibodies in the latent, immediate early lytic and early lytic phases. EBNA3A, BBLF1, BDLF4, and BLRF2 IgG antibodies were associated with all cancer types.Conclusions:Our observed similarities and differences across four EBV-associated cancers may inform EBV-related oncogenesis.Impact:Understanding the comparative humoral immune response across EBV-related cancers may aid in identifying shared etiologic roles of EBV proteins and inform unique pathogenic processes for each cancer.

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Lytic cycle Nasopharyngeal carcinoma Epstein–Barr virus Antibody Biology Lymphoma Immunology Immune system Cancer Cancer research Virus Virology Medicine Internal medicine Genetics Radiation therapy

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1055-9965.c.6624590
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4367601993

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DOI: https://doi.org/10.1158/1055-9965.c.6624590

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Title: Data from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

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Type: preprint

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Language: en

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Publication year: 2023

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Publication date: 2023-05-01

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Authors: Ilona Argirion, Ruth M. Pfeiffer, Carla Proietti, Anna E. Coghill, Kelly J. Yu, Jaap M. Middeldorp, Yomani D. Sarathkumara, Wan‐Lun Hsu, Yin-Chu Chien, Pei‐Jen Lou, Cheng‐Ping Wang, Nathaniel Rothman, Qing Lan, Chien‐Jen Chen, Sam M. Mbulaiteye, Ruth F. Jarrett, Ingrid Glimelius, Karin E. Smedby, Henrik Hjalgrim, Allan Hildesheim, Denise L. Doolan, Zhiwei Liu

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Concepts: Lytic cycle, Nasopharyngeal carcinoma, Epstein–Barr virus, Antibody, Biology, Lymphoma, Immunology, Immune system, Cancer, Cancer research, Virus, Virology, Medicine, Internal medicine, Genetics, Radiation therapy

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abstract_inverted_index.from	34
abstract_inverted_index.into	65
abstract_inverted_index.late	82, 167
abstract_inverted_index.life	158
abstract_inverted_index.same	42
abstract_inverted_index.type	69
abstract_inverted_index.were	38, 135, 150, 193
abstract_inverted_index.with	90, 137, 152, 161, 174, 195
abstract_inverted_index.(EBV)	2
abstract_inverted_index.BLRF2	190
abstract_inverted_index.NKTCL	57, 173
abstract_inverted_index.array	46
abstract_inverted_index.early	78, 80, 165, 180, 183
abstract_inverted_index.lytic	143, 168, 181, 184
abstract_inverted_index.roles	225
abstract_inverted_index.stage	75, 144
abstract_inverted_index.their	88, 116
abstract_inverted_index.type.	93
abstract_inverted_index.types	122
abstract_inverted_index.using	40, 123
abstract_inverted_index.viral	157
abstract_inverted_index.virus	1
abstract_inverted_index.whole	44
abstract_inverted_index.(NPC),	19
abstract_inverted_index.(cHL),	12
abstract_inverted_index.(eBL),	16
abstract_inverted_index.BBLF1,	187
abstract_inverted_index.BDLF4,	188
abstract_inverted_index.across	47, 118, 155, 203, 216
abstract_inverted_index.cancer	92, 113, 121, 197
abstract_inverted_index.cycle;	159
abstract_inverted_index.immune	214
abstract_inverted_index.inform	208, 230
abstract_inverted_index.linear	125
abstract_inverted_index.linked	4
abstract_inverted_index.lytic,	79, 81, 83, 166
abstract_inverted_index.shared	223
abstract_inverted_index.stages	134
abstract_inverted_index.subset	102
abstract_inverted_index.unique	231
abstract_inverted_index.Burkitt	14
abstract_inverted_index.EBNA3A,	186
abstract_inverted_index.Hodgkin	10
abstract_inverted_index.cancers	206, 218
abstract_inverted_index.endemic	13
abstract_inverted_index.focused	99
abstract_inverted_index.grouped	62
abstract_inverted_index.humoral	213
abstract_inverted_index.latent,	178
abstract_inverted_index.limited	140
abstract_inverted_index.natural	22
abstract_inverted_index.phases.	185
abstract_inverted_index.stages;	171
abstract_inverted_index.studies	50
abstract_inverted_index.(latent,	76
abstract_inverted_index.antibody	29, 128
abstract_inverted_index.cancers,	7
abstract_inverted_index.compared	115
abstract_inverted_index.lymphoma	11, 15, 24
abstract_inverted_index.measured	39
abstract_inverted_index.multiple	6
abstract_inverted_index.observed	199
abstract_inverted_index.pathways	66
abstract_inverted_index.proteins	37, 228
abstract_inverted_index.proteome	45
abstract_inverted_index.response	215
abstract_inverted_index.analysis,	97
abstract_inverted_index.carcinoma	18
abstract_inverted_index.cases/620	59
abstract_inverted_index.classical	9
abstract_inverted_index.etiologic	224
abstract_inverted_index.evaluated	87
abstract_inverted_index.immediate	77, 179
abstract_inverted_index.including	8
abstract_inverted_index.processes	233
abstract_inverted_index.responses	30, 129
abstract_inverted_index.sequences	33
abstract_inverted_index.targeting	31, 130
abstract_inverted_index.additional	96
abstract_inverted_index.anti-early	142
abstract_inverted_index.antibodies	64, 106, 154, 162, 175, 192
abstract_inverted_index.associated	136, 151, 194
abstract_inverted_index.candidates	110
abstract_inverted_index.controls).	60
abstract_inverted_index.extranodal	21
abstract_inverted_index.individual	105
abstract_inverted_index.life-cycle	74, 133
abstract_inverted_index.pathogenic	232
abstract_inverted_index.regression	126
abstract_inverted_index.EBV-related	209, 217
abstract_inverted_index.association	89
abstract_inverted_index.comparative	212
abstract_inverted_index.differences	202
abstract_inverted_index.identifying	222
abstract_inverted_index.EBV-positive	52
abstract_inverted_index.EBV-targeted	63
abstract_inverted_index.associations	117
abstract_inverted_index.glycoprotein	170
abstract_inverted_index.representing	107
abstract_inverted_index.similarities	200
abstract_inverted_index.glycoprotein)	85
abstract_inverted_index.investigating	51
abstract_inverted_index.killer/T-cell	23
abstract_inverted_index.multivariable	124
abstract_inverted_index.EBV-associated	205
abstract_inverted_index.case–control	49
abstract_inverted_index.immunoglobulin	68
abstract_inverted_index.nasopharyngeal	17
abstract_inverted_index.cancer.</p></div>	236
abstract_inverted_index.models.</p>Results:<p>IgA	127
abstract_inverted_index.types.</p>Conclusions:<p>Our	198
abstract_inverted_index.(NKTCL).</p>Methods:<p>Anti-EBV	25
abstract_inverted_index.oncogenesis.</p>Impact:<p>Understanding	210
abstract_inverted_index.<div>AbstractBackground:<p>Epstein–Barr	0
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	22
sustainable_development_goals[0].id	https://metadata.un.org/sdg/12
sustainable_development_goals[0].score	0.5199999809265137
sustainable_development_goals[0].display_name	Responsible consumption and production
citation_normalized_percentile.value	0.34178782
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False