Data from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Article Swipe
Qinxi Li
,
Xuan Wang
,
Xiaoling Wu
,
Yan‐Ning Rui
,
Wei Liu
,
Jifeng Wang
,
Xinghao Wang
,
Yih‐Cherng Liou
,
Zhiyun Ye
,
Sheng‐Cai Lin
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/0008-5472.c.6495177
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/0008-5472.c.6495177
Daxx, a death domain–associated protein, has been implicated in proapoptosis, antiapoptosis, and transcriptional regulation. Many factors known to play critically important roles in controlling apoptosis and gene transcription have been shown to associate with Daxx, including the Ser/Thr protein kinase HIPK2, promyelocytic leukemia protein, histone deacetylases, and the chromatin remodeling protein ATRX. Although it is clear that Daxx may exert multiple functions, the underlying mechanisms remain far from clear. Here, we show that Axin, originally identified for its scaffolding role to control β-catenin levels in Wnt signaling, strongly associates with Daxx at endogenous levels. The Daxx/Axin complex formation is enhanced by UV irradiation. Axin tethers Daxx to the tumor suppressor p53, and cooperates with Daxx, but not DaxxΔAxin, which is unable to interact with Axin, to stimulate HIPK2-mediated Ser46 phosphorylation and transcriptional activity of p53. Interestingly, Axin and Daxx seem to selectively activate p53 target genes, with strong activation of PUMA, but not p21 or Bax. Daxx-stimulated p53 transcriptional activity was significantly diminished by small interfering RNA against Axin; Daxx fails to inhibit colony formation in Axin−/− cells. Moreover, UV-induced cell death was attenuated by the knockdown of Axin and Daxx. All these results show that Daxx cooperates with Axin to stimulate p53, and implicate a direct role for Axin, HIPK2, and p53 in the proapoptotic function of Daxx. We have hence unraveled a novel aspect of p53 activation and shed new light on the ultimate understanding of the Daxx protein, perhaps most pertinently, in relation to stress-induced cell death. [Cancer Res 2007;67(1):66–74]
Related Topics
Concepts
Death-associated protein 6
Promyelocytic leukemia protein
Wnt signaling pathway
Cell biology
Biology
Histone
Chromatin remodeling
Chromatin
Cancer research
Transcription factor
Nuclear protein
Signal transduction
Gene
Genetics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/0008-5472.c.6495177
- OA Status
- gold
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4361265404
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4361265404Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1158/0008-5472.c.6495177Digital Object Identifier
- Title
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Data from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell DeathWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-30Full publication date if available
- Authors
-
Qinxi Li, Xuan Wang, Xiaoling Wu, Yan‐Ning Rui, Wei Liu, Jifeng Wang, Xinghao Wang, Yih‐Cherng Liou, Zhiyun Ye, Sheng‐Cai LinList of authors in order
- Landing page
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https://doi.org/10.1158/0008-5472.c.6495177Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1158/0008-5472.c.6495177Direct OA link when available
- Concepts
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Death-associated protein 6, Promyelocytic leukemia protein, Wnt signaling pathway, Cell biology, Biology, Histone, Chromatin remodeling, Chromatin, Cancer research, Transcription factor, Nuclear protein, Signal transduction, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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