Data from Expression Analysis of Juvenile Pilocytic Astrocytomas by Oligonucleotide Microarray Reveals Two Potential Subgroups Article Swipe
Kwong‐Kwok Wong
,
Yi-Mieng Chang
,
Yvonne T.M. Tsang
,
László Perlaky
,
Jack Su
,
Adekunle Adesina
,
Dawna L. Armstrong
,
Meenakshi Bhattacharjee
,
Thomas Dauser
,
Susan M. Blaney
,
Murali Chintagumpala
,
Ching C. Lau
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/0008-5472.c.6493047.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/0008-5472.c.6493047.v1
Juvenile pilocytic astrocytoma (JPA) is one of the most common brain tumors in children. The expression profiles of 21 JPAs, determined using Affymetrix GeneChip U133A, were compared with subjects with normal cerebella. The genes involved in neurogenesis, cell adhesion, synaptic transmission, central nervous system development, potassium ion transport, protein dephosphorylation, and cell differentiation were found to be significantly deregulated in JPA. These 21 JPAs were further clustered into two major groups by unsupervised hierarchical clustering using a set of 848 genes with high covariance (0.5-10). Supervised analysis with Significance Analysis of Microarrays software between these two potential subgroups identified a list of significant differentially expressed genes involved in cell adhesion, regulation of cell growth, cell motility, nerve ensheathment, and angiogenesis. Immunostaining of myelin basic protein on paraffin sections derived from 18 incompletely resected JPAs suggests that JPA without myelin basic protein–positively stained tumor cells may have a higher tendency to progress.
Related Topics
Concepts
Biology
Myelin basic protein
Microarray analysis techniques
Neurogenesis
Microarray
Tissue microarray
Astrocytoma
Glioma
Gene
Myelin
Molecular biology
Cell biology
Gene expression
Cancer research
Genetics
Cancer
Neuroscience
Central nervous system
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/0008-5472.c.6493047.v1
- OA Status
- gold
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4361256362
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4361256362Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1158/0008-5472.c.6493047.v1Digital Object Identifier
- Title
-
Data from Expression Analysis of Juvenile Pilocytic Astrocytomas by Oligonucleotide Microarray Reveals Two Potential SubgroupsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-03-30Full publication date if available
- Authors
-
Kwong‐Kwok Wong, Yi-Mieng Chang, Yvonne T.M. Tsang, László Perlaky, Jack Su, Adekunle Adesina, Dawna L. Armstrong, Meenakshi Bhattacharjee, Thomas Dauser, Susan M. Blaney, Murali Chintagumpala, Ching C. LauList of authors in order
- Landing page
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https://doi.org/10.1158/0008-5472.c.6493047.v1Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1158/0008-5472.c.6493047.v1Direct OA link when available
- Concepts
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Biology, Myelin basic protein, Microarray analysis techniques, Neurogenesis, Microarray, Tissue microarray, Astrocytoma, Glioma, Gene, Myelin, Molecular biology, Cell biology, Gene expression, Cancer research, Genetics, Cancer, Neuroscience, Central nervous systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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