Data from Genome-Wide Association Study of Pregnancy in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study Article Swipe

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Seth J Rotz , Sarah Worley , Bo Hu , Peter Bazeley , Jessica L. Baedke , Melissa M. Hudson , Dennis J. Kuo , Kevin C Oeffinger , Leslie L. Robison , Debashis Sahoo , Fan Wang , Yutaka Yasui , Gregory T. Armstrong , Smita Bhatia ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/1055-9965.c.8169940

Background:Gonadotoxic treatment-related infertility has a significant impact on quality of life in childhood cancer survivors. Genome-wide association analyses to delineate the risk of infertility in childhood cancer survivors have not been previously reported.Methods:Leveraging genotype data from a large survivor cohort, the Childhood Cancer Survivor Study (CCSS), we investigated the role of SNPs on future pregnancy or siring a pregnancy in survivors without pelvic, testicular, or brain radiation who had ever been married. We calculated sex-stratified hazard ratios, using Cox proportional hazards modeling, adjusting for birth cohort (before 1965 vs. 1965 or later) and doses of relevant chemotherapies; replication was attempted in the independent St. Jude Lifetime Cohort study (SJLIFE).Results:In the CCSS cohort, nine SNPs were found to be suggestive (P < 10^–7) or statistically significantly (P < 5 × 10^–8) associated with pregnancy, however, none of the SNPs were replicated in SJLIFE. Cohorts differed based on the overall pregnancy rate, frequency of sterilizing procedures, and birth cohort.Conclusions:We were not able to replicate our findings of SNPs associated with pregnancy in childhood cancer survivors.Impact:Future attempts at replication should be considered in cohorts treated in a comparable era. In addition, understanding the role of genetics in fertility in childhood cancer survivors may be better approached using more advanced sequencing techniques.

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Early Childhood Education

Demography

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Medicine Pregnancy Fertility Cohort Infertility Childhood cancer Cancer survivor Cohort study Hazard ratio Survivorship curve Single-nucleotide polymorphism Proportional hazards model Cancer Fertility preservation Oncology Gynecology Young adult Obstetrics Pediatrics Survival analysis Genotype Early childhood Live birth Human genetics Demography

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Landing Page: https://doi.org/10.1158/1055-9965.c.8169940
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Title: Data from Genome-Wide Association Study of Pregnancy in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study

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Publication year: 2025

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Publication date: 2025-11-26

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Authors: Seth J Rotz, Sarah Worley, Bo Hu, Peter Bazeley, Jessica L. Baedke, Melissa M. Hudson, Dennis J. Kuo, Kevin C Oeffinger, Leslie L. Robison, Debashis Sahoo, Fan Wang, Yutaka Yasui, Gregory T. Armstrong, Smita Bhatia

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Concepts: Medicine, Pregnancy, Fertility, Cohort, Infertility, Childhood cancer, Cancer survivor, Cohort study, Hazard ratio, Survivorship curve, Single-nucleotide polymorphism, Proportional hazards model, Cancer, Fertility preservation, Oncology, Gynecology, Young adult, Obstetrics, Pediatrics, Survival analysis, Genotype, Early childhood, Live birth, Human genetics, Demography

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abstract_inverted_index.(SJLIFE).</p>Results:<p>In	108
abstract_inverted_index.cohort.</p>Conclusions:<p>We	156
abstract_inverted_index.survivors.</p>Impact:<p>Future	172
abstract_inverted_index.reported.</p>Methods:<p>Leveraging	32
abstract_inverted_index.<div>AbstractBackground:<p>Gonadotoxic	0
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	14
citation_normalized_percentile