Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells Article Swipe
Koen M.O. Galenkamp
,
Paulina Sosicka
,
M. Jung
,
M. Victoria Recouvreux
,
Yijuan Zhang
,
Matthew R. Moldenhauer
,
Giovanni Brandi
,
Hudson H. Freeze
,
Cosimo Commisso
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/2159-8290.c.6547861
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/2159-8290.c.6547861
abstractCancer cells reprogram their metabolism to meet elevated energy demands and favor glycolysis for energy production. This boost in glycolytic flux supports proliferation, but also generates acid in the form of hydrogen ions that must be eliminated from the cytoplasm to maintain the alkaline intracellular pH (pHi) associated with transformation. To cope with acid production, tumor cells employ ion transport systems, including the family of sodium–hydrogen exchangers (NHE). Here, we identify NHE7 as a novel regulator of pHi in pancreatic ductal adenocarcinoma (PDAC). We determine that NHE7 suppression causes alkalinization of the Golgi, leading to a buildup of cytosolic acid that diminishes tumor cell fitness mainly through the dysregulation of actin. Importantly, NHE7 knockdown in vivo leads to the abrogation of tumor growth. These results identify Golgi acidification as a mechanism to control pHi and point to the regulation of pHi as a possible therapeutic vulnerability in PDAC.Significance:NHE7 regulates cytosolic pH through Golgi acidification, which points to the Golgi as a “proton sink” for metabolic acid. Disruption of cytosolic pH homeostasis via NHE7 suppression compromises PDAC cell viability and tumor growth.See related commentary by Ward and DeNicola, p. 768.This article is highlighted in the In This Issue feature, p. 747
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/2159-8290.c.6547861
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392691455
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4392691455Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1158/2159-8290.c.6547861Digital Object Identifier
- Title
-
Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer CellsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-03Full publication date if available
- Authors
-
Koen M.O. Galenkamp, Paulina Sosicka, M. Jung, M. Victoria Recouvreux, Yijuan Zhang, Matthew R. Moldenhauer, Giovanni Brandi, Hudson H. Freeze, Cosimo CommissoList of authors in order
- Landing page
-
https://doi.org/10.1158/2159-8290.c.6547861Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1158/2159-8290.c.6547861Direct OA link when available
- Concepts
-
Golgi apparatus, Cytosol, Homeostasis, Chemistry, Pancreatic cancer, Cell biology, Cancer, Biochemistry, Internal medicine, Endoplasmic reticulum, Biology, Medicine, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4392691455 |
|---|---|
| doi | https://doi.org/10.1158/2159-8290.c.6547861 |
| ids.doi | https://doi.org/10.1158/2159-8290.c.6547861 |
| ids.openalex | https://openalex.org/W4392691455 |
| fwci | |
| type | preprint |
| title | Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11150 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.991599977016449 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1307 |
| topics[0].subfield.display_name | Cell Biology |
| topics[0].display_name | Endoplasmic Reticulum Stress and Disease |
| topics[1].id | https://openalex.org/T10617 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9731000065803528 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Cellular transport and secretion |
| topics[2].id | https://openalex.org/T12412 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9599999785423279 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Enzyme function and inhibition |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C119062480 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7871346473693848 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q83181 |
| concepts[0].display_name | Golgi apparatus |
| concepts[1].id | https://openalex.org/C98539663 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7743926644325256 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q220599 |
| concepts[1].display_name | Cytosol |
| concepts[2].id | https://openalex.org/C63645605 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7484462261199951 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q103191 |
| concepts[2].display_name | Homeostasis |
| concepts[3].id | https://openalex.org/C185592680 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5598066449165344 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[3].display_name | Chemistry |
| concepts[4].id | https://openalex.org/C2780210213 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5554613471031189 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q212961 |
| concepts[4].display_name | Pancreatic cancer |
| concepts[5].id | https://openalex.org/C95444343 |
| concepts[5].level | 1 |
| concepts[5].score | 0.5161932110786438 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[5].display_name | Cell biology |
| concepts[6].id | https://openalex.org/C121608353 |
| concepts[6].level | 2 |
| concepts[6].score | 0.3436809182167053 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[6].display_name | Cancer |
| concepts[7].id | https://openalex.org/C55493867 |
| concepts[7].level | 1 |
| concepts[7].score | 0.31058555841445923 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[7].display_name | Biochemistry |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.27043020725250244 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| concepts[9].id | https://openalex.org/C158617107 |
| concepts[9].level | 2 |
| concepts[9].score | 0.25989222526550293 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q79927 |
| concepts[9].display_name | Endoplasmic reticulum |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.24142146110534668 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C71924100 |
| concepts[11].level | 0 |
| concepts[11].score | 0.10409557819366455 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[11].display_name | Medicine |
| concepts[12].id | https://openalex.org/C181199279 |
| concepts[12].level | 2 |
| concepts[12].score | 0.08818650245666504 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[12].display_name | Enzyme |
| keywords[0].id | https://openalex.org/keywords/golgi-apparatus |
| keywords[0].score | 0.7871346473693848 |
| keywords[0].display_name | Golgi apparatus |
| keywords[1].id | https://openalex.org/keywords/cytosol |
| keywords[1].score | 0.7743926644325256 |
| keywords[1].display_name | Cytosol |
| keywords[2].id | https://openalex.org/keywords/homeostasis |
| keywords[2].score | 0.7484462261199951 |
| keywords[2].display_name | Homeostasis |
| keywords[3].id | https://openalex.org/keywords/chemistry |
| keywords[3].score | 0.5598066449165344 |
| keywords[3].display_name | Chemistry |
| keywords[4].id | https://openalex.org/keywords/pancreatic-cancer |
| keywords[4].score | 0.5554613471031189 |
| keywords[4].display_name | Pancreatic cancer |
| keywords[5].id | https://openalex.org/keywords/cell-biology |
| keywords[5].score | 0.5161932110786438 |
| keywords[5].display_name | Cell biology |
| keywords[6].id | https://openalex.org/keywords/cancer |
| keywords[6].score | 0.3436809182167053 |
| keywords[6].display_name | Cancer |
| keywords[7].id | https://openalex.org/keywords/biochemistry |
| keywords[7].score | 0.31058555841445923 |
| keywords[7].display_name | Biochemistry |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.27043020725250244 |
| keywords[8].display_name | Internal medicine |
| keywords[9].id | https://openalex.org/keywords/endoplasmic-reticulum |
| keywords[9].score | 0.25989222526550293 |
| keywords[9].display_name | Endoplasmic reticulum |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.24142146110534668 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/medicine |
| keywords[11].score | 0.10409557819366455 |
| keywords[11].display_name | Medicine |
| keywords[12].id | https://openalex.org/keywords/enzyme |
| keywords[12].score | 0.08818650245666504 |
| keywords[12].display_name | Enzyme |
| language | en |
| locations[0].id | doi:10.1158/2159-8290.c.6547861 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1158/2159-8290.c.6547861 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5078733977 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7220-6516 |
| authorships[0].author.display_name | Koen M.O. Galenkamp |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Koen M.O. Galenkamp |
| authorships[0].is_corresponding | False |
| authorships[1].author.id | https://openalex.org/A5051643898 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6693-9542 |
| authorships[1].author.display_name | Paulina Sosicka |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Paulina Sosicka |
| authorships[1].is_corresponding | False |
| authorships[2].author.id | https://openalex.org/A5058435713 |
| authorships[2].author.orcid | https://orcid.org/0009-0004-0872-2785 |
| authorships[2].author.display_name | M. Jung |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Michael Jung |
| authorships[2].is_corresponding | False |
| authorships[3].author.id | https://openalex.org/A5017746225 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | M. Victoria Recouvreux |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | M. Victoria Recouvreux |
| authorships[3].is_corresponding | False |
| authorships[4].author.id | https://openalex.org/A5019159624 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1392-1816 |
| authorships[4].author.display_name | Yijuan Zhang |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yijuan Zhang |
| authorships[4].is_corresponding | False |
| authorships[5].author.id | https://openalex.org/A5074031619 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6596-6231 |
| authorships[5].author.display_name | Matthew R. Moldenhauer |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Matthew R. Moldenhauer |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A5068055005 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0013-2858 |
| authorships[6].author.display_name | Giovanni Brandi |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Giovanni Brandi |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A5014532793 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-6316-0501 |
| authorships[7].author.display_name | Hudson H. Freeze |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Hudson H. Freeze |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A5080326390 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-7884-9210 |
| authorships[8].author.display_name | Cosimo Commisso |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Cosimo Commisso |
| authorships[8].is_corresponding | False |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1158/2159-8290.c.6547861 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11150 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.991599977016449 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1307 |
| primary_topic.subfield.display_name | Cell Biology |
| primary_topic.display_name | Endoplasmic Reticulum Stress and Disease |
| related_works | https://openalex.org/W2062359679, https://openalex.org/W2042012519, https://openalex.org/W632193296, https://openalex.org/W2108606486, https://openalex.org/W1820744275, https://openalex.org/W2491383002, https://openalex.org/W1971094146, https://openalex.org/W1997516271, https://openalex.org/W4254318056, https://openalex.org/W4224865637 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1158/2159-8290.c.6547861 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1158/2159-8290.c.6547861 |
| primary_location.id | doi:10.1158/2159-8290.c.6547861 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1158/2159-8290.c.6547861 |
| publication_date | 2023-04-03 |
| publication_year | 2023 |
| referenced_works_count | 0 |
| abstract_inverted_index.a | 73, 95, 129, 142, 160 |
| abstract_inverted_index.In | 194 |
| abstract_inverted_index.To | 50 |
| abstract_inverted_index.We | 83 |
| abstract_inverted_index.as | 72, 128, 141, 159 |
| abstract_inverted_index.be | 35 |
| abstract_inverted_index.by | 183 |
| abstract_inverted_index.in | 18, 27, 78, 146, 192 |
| abstract_inverted_index.is | 190 |
| abstract_inverted_index.of | 30, 64, 76, 90, 97, 109, 120, 139, 167 |
| abstract_inverted_index.p. | 187, 198 |
| abstract_inverted_index.pH | 45, 150, 169 |
| abstract_inverted_index.to | 5, 40, 94, 117, 131, 136, 156 |
| abstract_inverted_index.we | 69 |
| abstract_inverted_index.and | 10, 134, 178, 185 |
| abstract_inverted_index.but | 23 |
| abstract_inverted_index.for | 13, 163 |
| abstract_inverted_index.ion | 58 |
| abstract_inverted_index.pHi | 77, 133, 140 |
| abstract_inverted_index.the | 28, 38, 42, 62, 91, 107, 118, 137, 157, 193 |
| abstract_inverted_index.via | 171 |
| abstract_inverted_index.NHE7 | 71, 86, 112, 172 |
| abstract_inverted_index.PDAC | 175 |
| abstract_inverted_index.This | 16, 195 |
| abstract_inverted_index.Ward | 184 |
| abstract_inverted_index.acid | 26, 53, 99 |
| abstract_inverted_index.also | 24 |
| abstract_inverted_index.cell | 103, 176 |
| abstract_inverted_index.cope | 51 |
| abstract_inverted_index.flux | 20 |
| abstract_inverted_index.form | 29 |
| abstract_inverted_index.from | 37 |
| abstract_inverted_index.ions | 32 |
| abstract_inverted_index.meet | 6 |
| abstract_inverted_index.must | 34 |
| abstract_inverted_index.that | 33, 85, 100 |
| abstract_inverted_index.with | 48, 52 |
| abstract_inverted_index.(pHi) | 46 |
| abstract_inverted_index.Golgi | 126, 152, 158 |
| abstract_inverted_index.Here, | 68 |
| abstract_inverted_index.Issue | 196 |
| abstract_inverted_index.These | 123 |
| abstract_inverted_index.acid. | 165 |
| abstract_inverted_index.boost | 17 |
| abstract_inverted_index.cells | 1, 56 |
| abstract_inverted_index.favor | 11 |
| abstract_inverted_index.leads | 116 |
| abstract_inverted_index.novel | 74 |
| abstract_inverted_index.point | 135 |
| abstract_inverted_index.their | 3 |
| abstract_inverted_index.tumor | 55, 102, 121, 179 |
| abstract_inverted_index.which | 154 |
| abstract_inverted_index.(NHE). | 67 |
| abstract_inverted_index.Golgi, | 92 |
| abstract_inverted_index.actin. | 110 |
| abstract_inverted_index.causes | 88 |
| abstract_inverted_index.ductal | 80 |
| abstract_inverted_index.employ | 57 |
| abstract_inverted_index.energy | 8, 14 |
| abstract_inverted_index.family | 63 |
| abstract_inverted_index.mainly | 105 |
| abstract_inverted_index.points | 155 |
| abstract_inverted_index.(PDAC). | 82 |
| abstract_inverted_index.article | 189 |
| abstract_inverted_index.buildup | 96 |
| abstract_inverted_index.control | 132 |
| abstract_inverted_index.demands | 9 |
| abstract_inverted_index.fitness | 104 |
| abstract_inverted_index.growth. | 122 |
| abstract_inverted_index.leading | 93 |
| abstract_inverted_index.related | 181 |
| abstract_inverted_index.results | 124 |
| abstract_inverted_index.sink” | 162 |
| abstract_inverted_index.through | 106, 151 |
| abstract_inverted_index.alkaline | 43 |
| abstract_inverted_index.elevated | 7 |
| abstract_inverted_index.feature, | 197 |
| abstract_inverted_index.hydrogen | 31 |
| abstract_inverted_index.identify | 70, 125 |
| abstract_inverted_index.maintain | 41 |
| abstract_inverted_index.possible | 143 |
| abstract_inverted_index.supports | 21 |
| abstract_inverted_index.systems, | 60 |
| abstract_inverted_index.DeNicola, | 186 |
| abstract_inverted_index.cytoplasm | 39 |
| abstract_inverted_index.cytosolic | 98, 149, 168 |
| abstract_inverted_index.determine | 84 |
| abstract_inverted_index.generates | 25 |
| abstract_inverted_index.including | 61 |
| abstract_inverted_index.knockdown | 113 |
| abstract_inverted_index.mechanism | 130 |
| abstract_inverted_index.metabolic | 164 |
| abstract_inverted_index.regulates | 148 |
| abstract_inverted_index.regulator | 75 |
| abstract_inverted_index.reprogram | 2 |
| abstract_inverted_index.transport | 59 |
| abstract_inverted_index.viability | 177 |
| abstract_inverted_index.“proton | 161 |
| abstract_inverted_index.Disruption | 166 |
| abstract_inverted_index.abrogation | 119 |
| abstract_inverted_index.associated | 47 |
| abstract_inverted_index.commentary | 182 |
| abstract_inverted_index.diminishes | 101 |
| abstract_inverted_index.eliminated | 36 |
| abstract_inverted_index.exchangers | 66 |
| abstract_inverted_index.glycolysis | 12 |
| abstract_inverted_index.glycolytic | 19 |
| abstract_inverted_index.metabolism | 4 |
| abstract_inverted_index.pancreatic | 79 |
| abstract_inverted_index.regulation | 138 |
| abstract_inverted_index.<i>in | 114 |
| abstract_inverted_index.compromises | 174 |
| abstract_inverted_index.highlighted | 191 |
| abstract_inverted_index.homeostasis | 170 |
| abstract_inverted_index.production, | 54 |
| abstract_inverted_index.production. | 15 |
| abstract_inverted_index.suppression | 87, 173 |
| abstract_inverted_index.therapeutic | 144 |
| abstract_inverted_index.Importantly, | 111 |
| abstract_inverted_index.acidification | 127 |
| abstract_inverted_index.dysregulation | 108 |
| abstract_inverted_index.intracellular | 44 |
| abstract_inverted_index.vulnerability | 145 |
| abstract_inverted_index.acidification, | 153 |
| abstract_inverted_index.adenocarcinoma | 81 |
| abstract_inverted_index.alkalinization | 89 |
| abstract_inverted_index.proliferation, | 22 |
| abstract_inverted_index.vivo</i> | 115 |
| abstract_inverted_index.transformation. | 49 |
| abstract_inverted_index.sodium–hydrogen | 65 |
| abstract_inverted_index.747</i></p></div> | 199 |
| abstract_inverted_index.growth.</p><p><i>See | 180 |
| abstract_inverted_index.PDAC.</p>Significance:<p>NHE7 | 147 |
| abstract_inverted_index.<div>Abstractabstract<p>Cancer | 0 |
| abstract_inverted_index.768</i>.</p><p><i>This | 188 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/7 |
| sustainable_development_goals[0].score | 0.75 |
| sustainable_development_goals[0].display_name | Affordable and clean energy |
| citation_normalized_percentile.value | 0.39401512 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |