Data from Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors Article Swipe

View

Pauline Lagarde , Gaëlle Pérot , Audrey Kauffmann , Céline Brulard , Valérie Dapremont , Isabelle Hostein , Agnès Neuville , Agnieszka Woźniak , Raf Sciot , Patrick Schöffski , Alain Aurias , Jean‐Michel Coindre , Maria Dêbiec‐Rychter , Frédéric Chibon ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.c.6519807

Purpose: The importance of KIT and PDGFRA mutations in the oncogenesis of gastrointestinal stromal tumors (GIST) is well established, but the genetic basis of GIST metastasis is poorly understood. We recently published a 67 gene expression prognostic signature related to genome complexity (CINSARC for Complexity INdex in SARComas) and asked whether it could predict outcome in GISTs.Experimental Design: We carried out genome and expression profiling on 67 primary untreated GISTs.Results: We show and validate here that it can predict metastasis in a new data set of 67 primary untreated GISTs. The gene whose expression was most strongly associated with metastasis was AURKA, but the AURKA locus was not amplified. Instead, we identified deletion of the p16 (CDKN2A) and retinoblastoma (RB1) genes as likely causal events leading to increased AURKA and CINSARC gene expression, to chromosome rearrangement, and ultimately to metastasis. On the basis of these findings, we established a Genomic Index that integrates the number and type of DNA copy number alterations. This index is a strong prognostic factor in GISTs. We show that CINSARC class, AURKA expression, and Genomic Index all outperform the Armed Forces Institute of Pathology (AFIP) grading system in determining the prognosis of patients with GISTs. Interestingly, these signatures can identify poor prognosis patients in the group classified as intermediate-risk by the AFIP classification.Conclusions: We propose that a high Genomic Index determined by comparative genomic hybridization from formalin-fixed, paraffin-embedded samples could be used to identify AFIP intermediate-risk patients who would benefit from imatinib therapy. Clin Cancer Res; 18(3); 826–38. ©2011 AACR.

Related Topics

Concepts

CDKN2A Metastasis Cancer research Biology PDGFRA Mitotic index Chromosome instability Genome instability GiST Stromal cell Gene Genetics Chromosome Cancer Mitosis DNA DNA damage

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1078-0432.c.6519807
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4361944220

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4361944220

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/1078-0432.c.6519807

Digital Object Identifier
Title: Data from Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-03-31

Full publication date if available
Authors: Pauline Lagarde, Gaëlle Pérot, Audrey Kauffmann, Céline Brulard, Valérie Dapremont, Isabelle Hostein, Agnès Neuville, Agnieszka Woźniak, Raf Sciot, Patrick Schöffski, Alain Aurias, Jean‐Michel Coindre, Maria Dêbiec‐Rychter, Frédéric Chibon

List of authors in order
Landing page: https://doi.org/10.1158/1078-0432.c.6519807

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1158/1078-0432.c.6519807

Direct OA link when available
Concepts: CDKN2A, Metastasis, Cancer research, Biology, PDGFRA, Mitotic index, Chromosome instability, Genome instability, GiST, Stromal cell, Gene, Genetics, Chromosome, Cancer, Mitosis, DNA, DNA damage

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4361944220
doi	https://doi.org/10.1158/1078-0432.c.6519807
ids.doi	https://doi.org/10.1158/1078-0432.c.6519807
ids.openalex	https://openalex.org/W4361944220
fwci	0.0
type	preprint
title	Data from Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T11485
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9998999834060669
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2715
topics[0].subfield.display_name	Gastroenterology
topics[0].display_name	Gastrointestinal Tumor Research and Treatment
topics[1].id	https://openalex.org/T10253
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9750999808311462
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2740
topics[1].subfield.display_name	Pulmonary and Respiratory Medicine
topics[1].display_name	Sarcoma Diagnosis and Treatment
topics[2].id	https://openalex.org/T11855
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9404000043869019
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2746
topics[2].subfield.display_name	Surgery
topics[2].display_name	Gastrointestinal disorders and treatments
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2780265364
concepts[0].level	3
concepts[0].score	0.6810961365699768
concepts[0].wikidata	https://www.wikidata.org/wiki/Q5009957
concepts[0].display_name	CDKN2A
concepts[1].id	https://openalex.org/C2779013556
concepts[1].level	3
concepts[1].score	0.5824441909790039
concepts[1].wikidata	https://www.wikidata.org/wiki/Q181876
concepts[1].display_name	Metastasis
concepts[2].id	https://openalex.org/C502942594
concepts[2].level	1
concepts[2].score	0.5787713527679443
concepts[2].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[2].display_name	Cancer research
concepts[3].id	https://openalex.org/C86803240
concepts[3].level	0
concepts[3].score	0.5225852727890015
concepts[3].wikidata	https://www.wikidata.org/wiki/Q420
concepts[3].display_name	Biology
concepts[4].id	https://openalex.org/C37307934
concepts[4].level	4
concepts[4].score	0.5056662559509277
concepts[4].wikidata	https://www.wikidata.org/wiki/Q18030422
concepts[4].display_name	PDGFRA
concepts[5].id	https://openalex.org/C66640590
concepts[5].level	3
concepts[5].score	0.47173798084259033
concepts[5].wikidata	https://www.wikidata.org/wiki/Q4296711
concepts[5].display_name	Mitotic index
concepts[6].id	https://openalex.org/C140752955
concepts[6].level	4
concepts[6].score	0.43952322006225586
concepts[6].wikidata	https://www.wikidata.org/wiki/Q1087752
concepts[6].display_name	Chromosome instability
concepts[7].id	https://openalex.org/C178169997
concepts[7].level	4
concepts[7].score	0.4331638514995575
concepts[7].wikidata	https://www.wikidata.org/wiki/Q2892636
concepts[7].display_name	Genome instability
concepts[8].id	https://openalex.org/C2775922572
concepts[8].level	3
concepts[8].score	0.3992115259170532
concepts[8].wikidata	https://www.wikidata.org/wiki/Q83567
concepts[8].display_name	GiST
concepts[9].id	https://openalex.org/C16930146
concepts[9].level	2
concepts[9].score	0.3954695165157318
concepts[9].wikidata	https://www.wikidata.org/wiki/Q4381253
concepts[9].display_name	Stromal cell
concepts[10].id	https://openalex.org/C104317684
concepts[10].level	2
concepts[10].score	0.3597084879875183
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[10].display_name	Gene
concepts[11].id	https://openalex.org/C54355233
concepts[11].level	1
concepts[11].score	0.2879562973976135
concepts[11].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[11].display_name	Genetics
concepts[12].id	https://openalex.org/C30481170
concepts[12].level	3
concepts[12].score	0.2583232522010803
concepts[12].wikidata	https://www.wikidata.org/wiki/Q37748
concepts[12].display_name	Chromosome
concepts[13].id	https://openalex.org/C121608353
concepts[13].level	2
concepts[13].score	0.23236781358718872
concepts[13].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[13].display_name	Cancer
concepts[14].id	https://openalex.org/C93304396
concepts[14].level	2
concepts[14].score	0.15259814262390137
concepts[14].wikidata	https://www.wikidata.org/wiki/Q14763008
concepts[14].display_name	Mitosis
concepts[15].id	https://openalex.org/C552990157
concepts[15].level	2
concepts[15].score	0.12264630198478699
concepts[15].wikidata	https://www.wikidata.org/wiki/Q7430
concepts[15].display_name	DNA
concepts[16].id	https://openalex.org/C143425029
concepts[16].level	3
concepts[16].score	0.0
concepts[16].wikidata	https://www.wikidata.org/wiki/Q5205747
concepts[16].display_name	DNA damage
keywords[0].id	https://openalex.org/keywords/cdkn2a
keywords[0].score	0.6810961365699768
keywords[0].display_name	CDKN2A
keywords[1].id	https://openalex.org/keywords/metastasis
keywords[1].score	0.5824441909790039
keywords[1].display_name	Metastasis
keywords[2].id	https://openalex.org/keywords/cancer-research
keywords[2].score	0.5787713527679443
keywords[2].display_name	Cancer research
keywords[3].id	https://openalex.org/keywords/biology
keywords[3].score	0.5225852727890015
keywords[3].display_name	Biology
keywords[4].id	https://openalex.org/keywords/pdgfra
keywords[4].score	0.5056662559509277
keywords[4].display_name	PDGFRA
keywords[5].id	https://openalex.org/keywords/mitotic-index
keywords[5].score	0.47173798084259033
keywords[5].display_name	Mitotic index
keywords[6].id	https://openalex.org/keywords/chromosome-instability
keywords[6].score	0.43952322006225586
keywords[6].display_name	Chromosome instability
keywords[7].id	https://openalex.org/keywords/genome-instability
keywords[7].score	0.4331638514995575
keywords[7].display_name	Genome instability
keywords[8].id	https://openalex.org/keywords/gist
keywords[8].score	0.3992115259170532
keywords[8].display_name	GiST
keywords[9].id	https://openalex.org/keywords/stromal-cell
keywords[9].score	0.3954695165157318
keywords[9].display_name	Stromal cell
keywords[10].id	https://openalex.org/keywords/gene
keywords[10].score	0.3597084879875183
keywords[10].display_name	Gene
keywords[11].id	https://openalex.org/keywords/genetics
keywords[11].score	0.2879562973976135
keywords[11].display_name	Genetics
keywords[12].id	https://openalex.org/keywords/chromosome
keywords[12].score	0.2583232522010803
keywords[12].display_name	Chromosome
keywords[13].id	https://openalex.org/keywords/cancer
keywords[13].score	0.23236781358718872
keywords[13].display_name	Cancer
keywords[14].id	https://openalex.org/keywords/mitosis
keywords[14].score	0.15259814262390137
keywords[14].display_name	Mitosis
keywords[15].id	https://openalex.org/keywords/dna
keywords[15].score	0.12264630198478699
keywords[15].display_name	DNA
language	en
locations[0].id	doi:10.1158/1078-0432.c.6519807
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/1078-0432.c.6519807
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5112905043
authorships[0].author.orcid
authorships[0].author.display_name	Pauline Lagarde
authorships[0].author_position	first
authorships[0].raw_author_name	Pauline Lagarde
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5070464592
authorships[1].author.orcid	https://orcid.org/0000-0002-6951-3934
authorships[1].author.display_name	Gaëlle Pérot
authorships[1].author_position	middle
authorships[1].raw_author_name	Gaëlle Pérot
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5114045802
authorships[2].author.orcid	https://orcid.org/0000-0002-5560-4210
authorships[2].author.display_name	Audrey Kauffmann
authorships[2].author_position	middle
authorships[2].raw_author_name	Audrey Kauffmann
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5085957270
authorships[3].author.orcid
authorships[3].author.display_name	Céline Brulard
authorships[3].author_position	middle
authorships[3].raw_author_name	Céline Brulard
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5000130545
authorships[4].author.orcid
authorships[4].author.display_name	Valérie Dapremont
authorships[4].author_position	middle
authorships[4].raw_author_name	Valérie Dapremont
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5090601954
authorships[5].author.orcid
authorships[5].author.display_name	Isabelle Hostein
authorships[5].author_position	middle
authorships[5].raw_author_name	Isabelle Hostein
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5104088562
authorships[6].author.orcid
authorships[6].author.display_name	Agnès Neuville
authorships[6].author_position	middle
authorships[6].raw_author_name	Agnès Neuville
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5055506828
authorships[7].author.orcid	https://orcid.org/0000-0001-9726-144X
authorships[7].author.display_name	Agnieszka Woźniak
authorships[7].author_position	middle
authorships[7].raw_author_name	Agnieszka Wozniak
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5086102127
authorships[8].author.orcid	https://orcid.org/0000-0003-2244-5839
authorships[8].author.display_name	Raf Sciot
authorships[8].author_position	middle
authorships[8].raw_author_name	Raf Sciot
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5021550191
authorships[9].author.orcid	https://orcid.org/0000-0001-5980-030X
authorships[9].author.display_name	Patrick Schöffski
authorships[9].author_position	middle
authorships[9].raw_author_name	Patrick Schöffski
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5062271071
authorships[10].author.orcid
authorships[10].author.display_name	Alain Aurias
authorships[10].author_position	middle
authorships[10].raw_author_name	Alain Aurias
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5108618420
authorships[11].author.orcid
authorships[11].author.display_name	Jean‐Michel Coindre
authorships[11].author_position	middle
authorships[11].raw_author_name	Jean-Michel Coindre
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5015197719
authorships[12].author.orcid	https://orcid.org/0000-0001-8183-2105
authorships[12].author.display_name	Maria Dêbiec‐Rychter
authorships[12].author_position	middle
authorships[12].raw_author_name	Maria Debiec-Rychter
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5055932045
authorships[13].author.orcid	https://orcid.org/0000-0002-6548-2181
authorships[13].author.display_name	Frédéric Chibon
authorships[13].author_position	last
authorships[13].raw_author_name	Frédéric Chibon
authorships[13].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1158/1078-0432.c.6519807
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Data from Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T11485
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9998999834060669
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2715
primary_topic.subfield.display_name	Gastroenterology
primary_topic.display_name	Gastrointestinal Tumor Research and Treatment
related_works	https://openalex.org/W2618986566, https://openalex.org/W2098769877, https://openalex.org/W2833317677, https://openalex.org/W3087046079, https://openalex.org/W2179755397, https://openalex.org/W2236930253, https://openalex.org/W2074509853, https://openalex.org/W3011280206, https://openalex.org/W3024644739, https://openalex.org/W3175839257
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1158/1078-0432.c.6519807
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/1078-0432.c.6519807
primary_location.id	doi:10.1158/1078-0432.c.6519807
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/1078-0432.c.6519807
publication_date	2023-03-31
publication_year	2023
referenced_works_count	0
abstract_inverted_index.a	32, 81, 148, 165, 221
abstract_inverted_index.67	33, 66, 86
abstract_inverted_index.On	140
abstract_inverted_index.We	29, 58, 70, 171, 218
abstract_inverted_index.as	121, 212
abstract_inverted_index.be	235
abstract_inverted_index.by	214, 226
abstract_inverted_index.in	8, 46, 55, 80, 169, 192, 208
abstract_inverted_index.is	16, 26, 164
abstract_inverted_index.it	51, 76
abstract_inverted_index.of	3, 11, 23, 85, 113, 143, 157, 187, 196
abstract_inverted_index.on	65
abstract_inverted_index.to	39, 126, 133, 138, 237
abstract_inverted_index.we	110, 146
abstract_inverted_index.DNA	158
abstract_inverted_index.The	1, 90
abstract_inverted_index.all	181
abstract_inverted_index.and	5, 48, 62, 72, 117, 129, 136, 155, 178
abstract_inverted_index.but	19, 102
abstract_inverted_index.can	77, 203
abstract_inverted_index.for	43
abstract_inverted_index.new	82
abstract_inverted_index.not	107
abstract_inverted_index.out	60
abstract_inverted_index.set	84
abstract_inverted_index.the	9, 20, 103, 114, 141, 153, 183, 194, 209, 215
abstract_inverted_index.was	94, 100, 106
abstract_inverted_index.who	242
abstract_inverted_index.AFIP	216, 239
abstract_inverted_index.GIST	24
abstract_inverted_index.Res;	250
abstract_inverted_index.This	162
abstract_inverted_index.copy	159
abstract_inverted_index.data	83
abstract_inverted_index.from	230, 245
abstract_inverted_index.gene	34, 91, 131
abstract_inverted_index.here	74
abstract_inverted_index.high	222
abstract_inverted_index.most	95
abstract_inverted_index.poor	205
abstract_inverted_index.show	71, 172
abstract_inverted_index.that	75, 151, 173, 220
abstract_inverted_index.type	156
abstract_inverted_index.used	236
abstract_inverted_index.well	17
abstract_inverted_index.with	98, 198
abstract_inverted_index.Armed	184
abstract_inverted_index.INdex	45
abstract_inverted_index.Index	150, 180, 224
abstract_inverted_index.asked	49
abstract_inverted_index.basis	22, 142
abstract_inverted_index.could	52, 234
abstract_inverted_index.genes	120
abstract_inverted_index.group	210
abstract_inverted_index.index	163
abstract_inverted_index.locus	105
abstract_inverted_index.these	144, 201
abstract_inverted_index.whose	92
abstract_inverted_index.would	243
abstract_inverted_index.(AFIP)	189
abstract_inverted_index.(GIST)	15
abstract_inverted_index.18(3);	251
abstract_inverted_index.Cancer	249
abstract_inverted_index.Forces	185
abstract_inverted_index.GISTs.	89, 170, 199
abstract_inverted_index.causal	123
abstract_inverted_index.class,	175
abstract_inverted_index.events	124
abstract_inverted_index.factor	168
abstract_inverted_index.genome	40, 61
abstract_inverted_index.likely	122
abstract_inverted_index.number	154, 160
abstract_inverted_index.poorly	27
abstract_inverted_index.strong	166
abstract_inverted_index.system	191
abstract_inverted_index.tumors	14
abstract_inverted_index.©2011	253
abstract_inverted_index.CINSARC	130, 174
abstract_inverted_index.Genomic	149, 179, 223
abstract_inverted_index.benefit	244
abstract_inverted_index.carried	59
abstract_inverted_index.genetic	21
abstract_inverted_index.genomic	228
abstract_inverted_index.grading	190
abstract_inverted_index.leading	125
abstract_inverted_index.outcome	54
abstract_inverted_index.predict	53, 78
abstract_inverted_index.primary	67, 87
abstract_inverted_index.propose	219
abstract_inverted_index.related	38
abstract_inverted_index.samples	233
abstract_inverted_index.stromal	13
abstract_inverted_index.whether	50
abstract_inverted_index.(CINSARC	42
abstract_inverted_index.Instead,	109
abstract_inverted_index.deletion	112
abstract_inverted_index.identify	204, 238
abstract_inverted_index.imatinib	246
abstract_inverted_index.patients	197, 207, 241
abstract_inverted_index.recently	30
abstract_inverted_index.strongly	96
abstract_inverted_index.therapy.	247
abstract_inverted_index.validate	73
abstract_inverted_index.826–38.	252
abstract_inverted_index.Institute	186
abstract_inverted_index.Pathology	188
abstract_inverted_index.SARComas)	47
abstract_inverted_index.findings,	145
abstract_inverted_index.increased	127
abstract_inverted_index.mutations	7
abstract_inverted_index.profiling	64
abstract_inverted_index.prognosis	195, 206
abstract_inverted_index.published	31
abstract_inverted_index.signature	37
abstract_inverted_index.untreated	68, 88
abstract_inverted_index.Complexity	44
abstract_inverted_index.amplified.	108
abstract_inverted_index.associated	97
abstract_inverted_index.chromosome	134
abstract_inverted_index.classified	211
abstract_inverted_index.complexity	41
abstract_inverted_index.determined	225
abstract_inverted_index.expression	35, 63, 93
abstract_inverted_index.identified	111
abstract_inverted_index.importance	2
abstract_inverted_index.integrates	152
abstract_inverted_index.metastasis	25, 79, 99
abstract_inverted_index.outperform	182
abstract_inverted_index.prognostic	36, 167
abstract_inverted_index.signatures	202
abstract_inverted_index.ultimately	137
abstract_inverted_index.comparative	227
abstract_inverted_index.determining	193
abstract_inverted_index.established	147
abstract_inverted_index.expression,	132, 177
abstract_inverted_index.metastasis.	139
abstract_inverted_index.oncogenesis	10
abstract_inverted_index.understood.	28
abstract_inverted_index.alterations.	161
abstract_inverted_index.established,	18
abstract_inverted_index.<i>Clin	248
abstract_inverted_index.hybridization	229
abstract_inverted_index.Interestingly,	200
abstract_inverted_index.rearrangement,	135
abstract_inverted_index.retinoblastoma	118
abstract_inverted_index.formalin-fixed,	231
abstract_inverted_index.gastrointestinal	12
abstract_inverted_index.Design:</b>	57
abstract_inverted_index.intermediate-risk	213, 240
abstract_inverted_index.paraffin-embedded	232
abstract_inverted_index.<i>KIT</i>	4
abstract_inverted_index.<i>p16</i>	115
abstract_inverted_index.<i>AURKA</i>	104, 128, 176
abstract_inverted_index.(<i>RB1</i>)	119
abstract_inverted_index.<i>AURKA</i>,	101
abstract_inverted_index.<i>PDGFRA</i>	6
abstract_inverted_index.(<i>CDKN2A</i>)	116
abstract_inverted_index.AACR</i>.</p></div>	254
abstract_inverted_index.GISTs.</p><p><b>Experimental	56
abstract_inverted_index.GISTs.</p><p><b>Results:</b>	69
abstract_inverted_index.<div>Abstract<p><b>Purpose:</b>	0
abstract_inverted_index.classification.</p><p><b>Conclusions:</b>	217
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	14
citation_normalized_percentile.value	0.08545105
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False