Data from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment Article Swipe
Murali M. Yallapu
,
Mara C. Ebeling
,
Sheema Khan
,
Vasudha Sundram
,
Neeraj Chauhan
,
Brij K. Gupta
,
Susan E. Puumala
,
Meena Jaggi
,
Subhash C. Chauhan
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/1535-7163.c.6536379.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/1535-7163.c.6536379.v1
Curcumin (CUR), a naturally occurring polyphenol derived from the root of Curcuma longa, has showed potent anticancer and cancer prevention activity in a variety of cancers. However, the clinical translation of CUR has been significantly hampered due to its extensive degradation, suboptimal pharmacokinetics, and poor bioavailability. To address these clinically relevant issues, we have developed a novel CUR-loaded magnetic nanoparticle (MNP-CUR) formulation. Herein, we have evaluated the in vitro and in vivo therapeutic efficacy of this novel MNP-CUR formulation in pancreatic cancer. Human pancreatic cancer cells (HPAF-II and Panc-1) exhibited efficient internalization of the MNP-CUR formulation in a dose-dependent manner. As a result, the MNP-CUR formulation effectively inhibited growth of HPAF-II and Panc-1 cells in cell proliferation and colony formation assays. The MNP-CUR formulation suppressed pancreatic tumor growth in an HPAF-II xenograft mouse model and improved the survival of mice by delaying tumor growth. The growth-inhibitory effect of MNP-CUR formulation correlated with the suppression of proliferating cell nuclear antigen (PCNA), B-cell lymphoma-extra large (Bcl-xL), induced myeloid leukemia cell differentiation protein (Mcl-1), cell surface–associated Mucin 1 (MUC1), collagen I, and enhanced membrane β-catenin expression. MNP-CUR formulation did not show any sign of hemotoxicity and was stable after incubation with human serum proteins. In addition, the MNP-CUR formulation improved serum bioavailability of CUR in mice up to 2.5-fold as compared with free CUR. Biodistribution studies show that a significant amount of MNP-CUR formulation was able to reach the pancreatic xenograft tumor(s), which suggests its clinical translational potential. In conclusion, this study suggests that our novel MNP-CUR formulation can be valuable for the treatment of pancreatic cancer. Mol Cancer Ther; 12(8); 1471–80. ©2013 AACR.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/1535-7163.c.6536379.v1
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4362495334Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1158/1535-7163.c.6536379.v1Digital Object Identifier
- Title
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Data from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer TreatmentWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-04-03Full publication date if available
- Authors
-
Murali M. Yallapu, Mara C. Ebeling, Sheema Khan, Vasudha Sundram, Neeraj Chauhan, Brij K. Gupta, Susan E. Puumala, Meena Jaggi, Subhash C. ChauhanList of authors in order
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https://doi.org/10.1158/1535-7163.c.6536379.v1Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1158/1535-7163.c.6536379.v1Direct OA link when available
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Curcumin, Chemistry, Cancer research, Pancreatic cancer, Cell growth, Pharmacology, In vivo, Proliferating cell nuclear antigen, Cell, Curcuma, In vitro, Cancer, Biology, Medicine, Biochemistry, Internal medicine, Paleontology, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.antigen | 158 |
| abstract_inverted_index.assays. | 120 |
| abstract_inverted_index.cancer. | 81, 263 |
| abstract_inverted_index.derived | 6 |
| abstract_inverted_index.growth. | 143 |
| abstract_inverted_index.induced | 164 |
| abstract_inverted_index.issues, | 51 |
| abstract_inverted_index.manner. | 99 |
| abstract_inverted_index.myeloid | 165 |
| abstract_inverted_index.nuclear | 157 |
| abstract_inverted_index.protein | 169 |
| abstract_inverted_index.result, | 102 |
| abstract_inverted_index.studies | 222 |
| abstract_inverted_index.variety | 23 |
| abstract_inverted_index.(HPAF-II | 86 |
| abstract_inverted_index.(Mcl-1), | 170 |
| abstract_inverted_index.2.5-fold | 215 |
| abstract_inverted_index.However, | 26 |
| abstract_inverted_index.activity | 20 |
| abstract_inverted_index.cancers. | 25 |
| abstract_inverted_index.clinical | 28, 242 |
| abstract_inverted_index.collagen | 176 |
| abstract_inverted_index.compared | 217 |
| abstract_inverted_index.delaying | 141 |
| abstract_inverted_index.efficacy | 73 |
| abstract_inverted_index.enhanced | 179 |
| abstract_inverted_index.hampered | 35 |
| abstract_inverted_index.improved | 135, 206 |
| abstract_inverted_index.leukemia | 166 |
| abstract_inverted_index.magnetic | 58 |
| abstract_inverted_index.membrane | 180 |
| abstract_inverted_index.relevant | 50 |
| abstract_inverted_index.suggests | 240, 249 |
| abstract_inverted_index.survival | 137 |
| abstract_inverted_index.valuable | 257 |
| abstract_inverted_index.(Bcl-xL), | 163 |
| abstract_inverted_index.(MNP-CUR) | 60 |
| abstract_inverted_index.addition, | 202 |
| abstract_inverted_index.developed | 54 |
| abstract_inverted_index.efficient | 90 |
| abstract_inverted_index.evaluated | 65 |
| abstract_inverted_index.exhibited | 89 |
| abstract_inverted_index.extensive | 39 |
| abstract_inverted_index.formation | 119 |
| abstract_inverted_index.inhibited | 107 |
| abstract_inverted_index.naturally | 3 |
| abstract_inverted_index.occurring | 4 |
| abstract_inverted_index.proteins. | 200 |
| abstract_inverted_index.treatment | 260 |
| abstract_inverted_index.tumor(s), | 238 |
| abstract_inverted_index.xenograft | 131, 237 |
| abstract_inverted_index.1471–80. | 268 |
| abstract_inverted_index.CUR-loaded | 57 |
| abstract_inverted_index.anticancer | 16 |
| abstract_inverted_index.clinically | 49 |
| abstract_inverted_index.correlated | 150 |
| abstract_inverted_index.incubation | 196 |
| abstract_inverted_index.pancreatic | 80, 83, 125, 236, 262 |
| abstract_inverted_index.polyphenol | 5 |
| abstract_inverted_index.potential. | 244 |
| abstract_inverted_index.prevention | 19 |
| abstract_inverted_index.suboptimal | 41 |
| abstract_inverted_index.suppressed | 124 |
| abstract_inverted_index.β-catenin | 181 |
| abstract_inverted_index.<i>in | 67, 70 |
| abstract_inverted_index.conclusion, | 246 |
| abstract_inverted_index.effectively | 106 |
| abstract_inverted_index.expression. | 182 |
| abstract_inverted_index.formulation | 78, 95, 105, 123, 149, 184, 205, 230, 254 |
| abstract_inverted_index.significant | 226 |
| abstract_inverted_index.suppression | 153 |
| abstract_inverted_index.therapeutic | 72 |
| abstract_inverted_index.translation | 29 |
| abstract_inverted_index.<i>Mol | 264 |
| abstract_inverted_index.degradation, | 40 |
| abstract_inverted_index.formulation. | 61 |
| abstract_inverted_index.hemotoxicity | 191 |
| abstract_inverted_index.nanoparticle | 59 |
| abstract_inverted_index.proliferating | 155 |
| abstract_inverted_index.proliferation | 116 |
| abstract_inverted_index.significantly | 34 |
| abstract_inverted_index.translational | 243 |
| abstract_inverted_index.dose-dependent | 98 |
| abstract_inverted_index.lymphoma-extra | 161 |
| abstract_inverted_index.vivo</i> | 71 |
| abstract_inverted_index.Biodistribution | 221 |
| abstract_inverted_index.bioavailability | 208 |
| abstract_inverted_index.differentiation | 168 |
| abstract_inverted_index.internalization | 91 |
| abstract_inverted_index.vitro</i> | 68 |
| abstract_inverted_index.<i>Curcuma | 11 |
| abstract_inverted_index.bioavailability. | 45 |
| abstract_inverted_index.longa</i>, | 12 |
| abstract_inverted_index.growth-inhibitory | 145 |
| abstract_inverted_index.pharmacokinetics, | 42 |
| abstract_inverted_index.surface–associated | 172 |
| abstract_inverted_index.<div>Abstract<p>Curcumin | 0 |
| abstract_inverted_index.AACR</i>.</p></div> | 270 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5799999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.0323621 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |