Data from Randomized Trial of a Personalized Dendritic Cell Vaccine after Autologous Stem Cell Transplant for Multiple Myeloma Article Swipe
David J. Chung
,
Nina Shah
,
Juan Wu
,
Brent R. Logan
,
Lina Bisharat
,
Natalie S. Callander
,
Giulia Cheloni
,
Kenneth C. Anderson
,
Thinle Chodon
,
Binod Dhakal
,
Steven M. Devine
,
Poorvi Somaiya Dutt
,
Yvonne A. Efebera
,
Nancy L. Geller
,
Haider Ghiasuddin
,
Peiman Hematti
,
Leona Holmberg
,
Alan Howard
,
Bryon D. Johnson
,
Dimitra Karagkouni
,
Hillard M. Lazarus
,
Ehsan Malek
,
Philip L. McCarthy
,
David H. McKenna
,
Adam Mendizabal
,
Ajay K. Nooka
,
Nikhil C. Munshi
,
Lynn O’Donnell
,
Aaron P. Rapoport
,
Jane Reese
,
Jacalyn Rosenblatt
,
Robert J. Soiffer
,
Dina Stroopinsky
,
Lynne Uhl
,
Ioannis S. Vlachos
,
Edmund K. Waller
,
James W. Young
,
Marcelo C. Pasquini
,
David Avigan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.c.6771813.v3
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.c.6771813.v3
Purpose: Vaccination with dendritic cell (DC)/multiple myeloma (MM) fusions has been shown to induce the expansion of circulating MM-reactive lymphocytes and consolidation of clinical response following autologous hematopoietic cell transplant (autoHCT). Patients and Methods: In this randomized phase II trial (NCT02728102), we assessed the effect of DC/MM fusion vaccination, GM-CSF, and lenalidomide maintenance as compared to control arms of GM-CSF and lenalidomide or lenalidomide maintenance alone on clinical response rates and induction of MM-specific immunity at 1-year post-transplant. Results: The study enrolled 203 patients, with 140 randomized post-transplantation. Vaccine production was successful in 63/68 patients. At 1 year, rates of CR were 52.9% (vaccine) and 50% (control) (p=0.37, 80% CI 44.5%, 61.3% and 41.6%, 58.4%, respectively), and rates of VGPR or better were 85.3% (vaccine) and 77.8% (control) (p=0.2). Conversion to CR at 1 year was 34.8% (vaccine) and 27.3% (control) (p=0.4). Vaccination induced a statistically significant expansion of MM-reactive T cells at 1 year as compared to prior to vaccination (p=0.024) and in contrast to the non-vaccine arm (p=0.026). Single-cell transcriptomics revealed clonotypic expansion of activated CD8 cells and shared dominant clonotypes between patients at 1-year post-transplant. Conclusions: DC/MM fusion vaccination with lenalidomide did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating MM-reactive lymphocytes indicative of tumor-specific immunity. Site-specific production of a personalized cell therapy with centralized product characterization was effectively accomplished in the context of a multicenter cooperative group study.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/1078-0432.c.6771813.v3
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402818897
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402818897Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1158/1078-0432.c.6771813.v3Digital Object Identifier
- Title
-
Data from Randomized Trial of a Personalized Dendritic Cell Vaccine after Autologous Stem Cell Transplant for Multiple MyelomaWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-16Full publication date if available
- Authors
-
David J. Chung, Nina Shah, Juan Wu, Brent R. Logan, Lina Bisharat, Natalie S. Callander, Giulia Cheloni, Kenneth C. Anderson, Thinle Chodon, Binod Dhakal, Steven M. Devine, Poorvi Somaiya Dutt, Yvonne A. Efebera, Nancy L. Geller, Haider Ghiasuddin, Peiman Hematti, Leona Holmberg, Alan Howard, Bryon D. Johnson, Dimitra Karagkouni, Hillard M. Lazarus, Ehsan Malek, Philip L. McCarthy, David H. McKenna, Adam Mendizabal, Ajay K. Nooka, Nikhil C. Munshi, Lynn O’Donnell, Aaron P. Rapoport, Jane Reese, Jacalyn Rosenblatt, Robert J. Soiffer, Dina Stroopinsky, Lynne Uhl, Ioannis S. Vlachos, Edmund K. Waller, James W. Young, Marcelo C. Pasquini, David AviganList of authors in order
- Landing page
-
https://doi.org/10.1158/1078-0432.c.6771813.v3Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1158/1078-0432.c.6771813.v3Direct OA link when available
- Concepts
-
Multiple myeloma, Stem cell, Medicine, Randomized controlled trial, Oncology, Internal medicine, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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