Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding Article Swipe
Barbara Belletti
,
Jayant S. Vaidya
,
Sara D’Andrea
,
Frank Entschladen
,
Mario Roncadin
,
Francesca Lovat
,
Stefania Berton
,
Tiziana Perin
,
Ezio Candiani
,
Sonia Reccanello
,
Andrea Veronesi
,
Vincenzo Canzonieri
,
M. Trovò
,
Kurt S. Zaenker
,
Alfonso Colombatti
,
Gustavo Baldassarre
,
Samuele Massarut
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.c.6518337
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.c.6518337
Purpose: After apparently successful excision of breast cancer, risk of local recurrence remains high mainly in the area surrounding the original tumor, indicating that wound healing processes may be implicated. The proportional reduction of this risk by radiotherapy does not depend on the extent of surgery, suggesting that radiotherapy, in addition to killing tumor cells, may influence the tumor microenvironment.Experimental Design: We studied how normal and mammary carcinoma cell growth and motility are affected by surgical wound fluids (WF), collected over 24 h following breast-conserving surgery in 45 patients, 20 of whom had received additional TARGeted Intraoperative radioTherapy (TARGIT), immediately after the surgical excision. The proteomic profile of the WF and their effects on the activation of intracellular signal transduction pathways of breast cancer cells were also analyzed.Results: WF stimulated proliferation, migration, and invasion of breast cancer cell lines. The stimulatory effect was almost completely abrogated when fluids from TARGIT-treated patients were used. These fluids displayed altered expression of several cytokines and failed to properly stimulate the activation of some intracellular signal transduction pathways, when compared with fluids harvested from untreated patients.Conclusions: Delivery of TARGIT to the tumor bed alters the molecular composition and biological activity of surgical WF. This novel antitumoral effect could, at least partially, explain the very low recurrence rates found in a large pilot study using TARGIT. It also opens a novel avenue for identifying new molecular targets and testing novel therapeutic agents.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/1078-0432.c.6518337
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4361943445
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4361943445Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1158/1078-0432.c.6518337Digital Object Identifier
- Title
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Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical WoundingWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-31Full publication date if available
- Authors
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Barbara Belletti, Jayant S. Vaidya, Sara D’Andrea, Frank Entschladen, Mario Roncadin, Francesca Lovat, Stefania Berton, Tiziana Perin, Ezio Candiani, Sonia Reccanello, Andrea Veronesi, Vincenzo Canzonieri, M. Trovò, Kurt S. Zaenker, Alfonso Colombatti, Gustavo Baldassarre, Samuele MassarutList of authors in order
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https://doi.org/10.1158/1078-0432.c.6518337Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1158/1078-0432.c.6518337Direct OA link when available
- Concepts
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Breast cancer, Medicine, Intracellular, Radiation therapy, Cancer research, Signal transduction, Cancer, Cell growth, Breast carcinoma, Stimulation, Internal medicine, Biology, Cell biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.depend | 40 |
| abstract_inverted_index.effect | 141, 202 |
| abstract_inverted_index.extent | 43 |
| abstract_inverted_index.failed | 162 |
| abstract_inverted_index.fluids | 77, 147, 154, 177 |
| abstract_inverted_index.growth | 69 |
| abstract_inverted_index.lines. | 138 |
| abstract_inverted_index.mainly | 14 |
| abstract_inverted_index.normal | 64 |
| abstract_inverted_index.signal | 118, 171 |
| abstract_inverted_index.tumor, | 21 |
| abstract_inverted_index.TARGIT. | 220 |
| abstract_inverted_index.altered | 156 |
| abstract_inverted_index.cancer, | 7 |
| abstract_inverted_index.effects | 112 |
| abstract_inverted_index.explain | 207 |
| abstract_inverted_index.healing | 25 |
| abstract_inverted_index.killing | 52 |
| abstract_inverted_index.mammary | 66 |
| abstract_inverted_index.profile | 106 |
| abstract_inverted_index.remains | 12 |
| abstract_inverted_index.several | 159 |
| abstract_inverted_index.studied | 62 |
| abstract_inverted_index.surgery | 85 |
| abstract_inverted_index.targets | 231 |
| abstract_inverted_index.testing | 233 |
| abstract_inverted_index.Delivery | 182 |
| abstract_inverted_index.activity | 195 |
| abstract_inverted_index.addition | 50 |
| abstract_inverted_index.affected | 73 |
| abstract_inverted_index.compared | 175 |
| abstract_inverted_index.excision | 4 |
| abstract_inverted_index.invasion | 133 |
| abstract_inverted_index.motility | 71 |
| abstract_inverted_index.original | 20 |
| abstract_inverted_index.pathways | 120 |
| abstract_inverted_index.patients | 150 |
| abstract_inverted_index.properly | 164 |
| abstract_inverted_index.received | 93 |
| abstract_inverted_index.surgery, | 45 |
| abstract_inverted_index.surgical | 75, 102, 197 |
| abstract_inverted_index.(TARGIT), | 98 |
| abstract_inverted_index.abrogated | 145 |
| abstract_inverted_index.carcinoma | 67 |
| abstract_inverted_index.collected | 79 |
| abstract_inverted_index.cytokines | 160 |
| abstract_inverted_index.displayed | 155 |
| abstract_inverted_index.excision. | 103 |
| abstract_inverted_index.following | 83 |
| abstract_inverted_index.harvested | 178 |
| abstract_inverted_index.influence | 56 |
| abstract_inverted_index.molecular | 191, 230 |
| abstract_inverted_index.pathways, | 173 |
| abstract_inverted_index.patients, | 88 |
| abstract_inverted_index.processes | 26 |
| abstract_inverted_index.proteomic | 105 |
| abstract_inverted_index.reduction | 32 |
| abstract_inverted_index.stimulate | 165 |
| abstract_inverted_index.untreated | 180 |
| abstract_inverted_index.activation | 115, 167 |
| abstract_inverted_index.additional | 94 |
| abstract_inverted_index.apparently | 2 |
| abstract_inverted_index.biological | 194 |
| abstract_inverted_index.completely | 144 |
| abstract_inverted_index.expression | 157 |
| abstract_inverted_index.indicating | 22 |
| abstract_inverted_index.migration, | 131 |
| abstract_inverted_index.partially, | 206 |
| abstract_inverted_index.recurrence | 11, 211 |
| abstract_inverted_index.stimulated | 129 |
| abstract_inverted_index.successful | 3 |
| abstract_inverted_index.suggesting | 46 |
| abstract_inverted_index.antitumoral | 201 |
| abstract_inverted_index.composition | 192 |
| abstract_inverted_index.identifying | 228 |
| abstract_inverted_index.immediately | 99 |
| abstract_inverted_index.implicated. | 29 |
| abstract_inverted_index.stimulatory | 140 |
| abstract_inverted_index.surrounding | 18 |
| abstract_inverted_index.therapeutic | 235 |
| abstract_inverted_index.proportional | 31 |
| abstract_inverted_index.radiotherapy | 37 |
| abstract_inverted_index.transduction | 119, 172 |
| abstract_inverted_index.intracellular | 117, 170 |
| abstract_inverted_index.radiotherapy, | 48 |
| abstract_inverted_index.TARGIT-treated | 149 |
| abstract_inverted_index.proliferation, | 130 |
| abstract_inverted_index.Design:</b> | 60 |
| abstract_inverted_index.breast-conserving | 84 |
| abstract_inverted_index.<i>TARG</i>eted | 95 |
| abstract_inverted_index.agents.</p></div> | 236 |
| abstract_inverted_index.radio<i>T</i>herapy | 97 |
| abstract_inverted_index.<i>I</i>ntraoperative | 96 |
| abstract_inverted_index.<div>Abstract<p><b>Purpose:</b> | 0 |
| abstract_inverted_index.analyzed.</p><p><b>Results:</b> | 127 |
| abstract_inverted_index.microenvironment.</p><p><b>Experimental | 59 |
| abstract_inverted_index.patients.</p><p><b>Conclusions:</b> | 181 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 17 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7699999809265137 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.16926076 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |