Data from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer Article Swipe

View

Tiara T. Byrd , Kristen Fousek , Antonella Pignata , Christopher Szot , Heba Samaha , Steven Seaman , Lacey E. Dobrolecki , Vita S. Salsman , Htoo Zarni Oo , Kevin Bielamowicz , Daniel Landi , Nino Rainusso , John Hicks , Suzanne Z. Powell , Matthew L. Baker , Winfried S. Wels , Joachim Koch , Poul H. Sorensen , Benjamin Deneen , Matthew J. Ellis , Michael T. Lewis , Meenakshi Hegde , Bradley S. Fletcher , Brad St. Croix , Nabil Ahmed ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/0008-5472.c.6510005

Triple-negative breast cancer (TNBC) is an aggressive disease lacking targeted therapy. In this study, we developed a CAR T cell–based immunotherapeutic strategy to target TEM8, a marker initially defined on endothelial cells in colon tumors that was discovered recently to be upregulated in TNBC. CAR T cells were developed that upon specific recognition of TEM8 secreted immunostimulatory cytokines and killed tumor endothelial cells as well as TEM8-positive TNBC cells. Notably, the TEM8 CAR T cells targeted breast cancer stem–like cells, offsetting the formation of mammospheres relative to nontransduced T cells. Adoptive transfer of TEM8 CAR T cells induced regression of established, localized patient-derived xenograft tumors, as well as lung metastatic TNBC cell line–derived xenograft tumors, by both killing TEM8⁺ TNBC tumor cells and targeting the tumor endothelium to block tumor neovascularization. Our findings offer a preclinical proof of concept for immunotherapeutic targeting of TEM8 as a strategy to treat TNBC.Significance: These findings offer a preclinical proof of concept for immunotherapeutic targeting of an endothelial antigen that is overexpressed in triple-negative breast cancer and the associated tumor vasculature. Cancer Res; 78(2); 489–500. ©2017 AACR.

Related Topics

Triple-Negative Breast Cancer

Concepts

Triple-negative breast cancer Cancer research Adoptive cell transfer Breast cancer Cancer Tumor microenvironment Immunology Medicine T cell Internal medicine Immune system Tumor cells

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/0008-5472.c.6510005
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4361850936

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4361850936

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/0008-5472.c.6510005

Digital Object Identifier
Title: Data from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-03-31

Full publication date if available
Authors: Tiara T. Byrd, Kristen Fousek, Antonella Pignata, Christopher Szot, Heba Samaha, Steven Seaman, Lacey E. Dobrolecki, Vita S. Salsman, Htoo Zarni Oo, Kevin Bielamowicz, Daniel Landi, Nino Rainusso, John Hicks, Suzanne Z. Powell, Matthew L. Baker, Winfried S. Wels, Joachim Koch, Poul H. Sorensen, Benjamin Deneen, Matthew J. Ellis, Michael T. Lewis, Meenakshi Hegde, Bradley S. Fletcher, Brad St. Croix, Nabil Ahmed

List of authors in order
Landing page: https://doi.org/10.1158/0008-5472.c.6510005

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1158/0008-5472.c.6510005

Direct OA link when available
Concepts: Triple-negative breast cancer, Cancer research, Adoptive cell transfer, Breast cancer, Cancer, Tumor microenvironment, Immunology, Medicine, T cell, Internal medicine, Immune system, Tumor cells

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4361850936
doi	https://doi.org/10.1158/0008-5472.c.6510005
ids.doi	https://doi.org/10.1158/0008-5472.c.6510005
ids.openalex	https://openalex.org/W4361850936
fwci	0.0
type	preprint
title	Data from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T11491
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9998000264167786
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2730
topics[0].subfield.display_name	Oncology
topics[0].display_name	CAR-T cell therapy research
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2780110267
concepts[0].level	4
concepts[0].score	0.9147883653640747
concepts[0].wikidata	https://www.wikidata.org/wiki/Q7843332
concepts[0].display_name	Triple-negative breast cancer
concepts[1].id	https://openalex.org/C502942594
concepts[1].level	1
concepts[1].score	0.6760543584823608
concepts[1].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[1].display_name	Cancer research
concepts[2].id	https://openalex.org/C90375314
concepts[2].level	4
concepts[2].score	0.5316783785820007
concepts[2].wikidata	https://www.wikidata.org/wiki/Q3537484
concepts[2].display_name	Adoptive cell transfer
concepts[3].id	https://openalex.org/C530470458
concepts[3].level	3
concepts[3].score	0.5196996331214905
concepts[3].wikidata	https://www.wikidata.org/wiki/Q128581
concepts[3].display_name	Breast cancer
concepts[4].id	https://openalex.org/C121608353
concepts[4].level	2
concepts[4].score	0.5036844611167908
concepts[4].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[4].display_name	Cancer
concepts[5].id	https://openalex.org/C2776107976
concepts[5].level	3
concepts[5].score	0.4208592176437378
concepts[5].wikidata	https://www.wikidata.org/wiki/Q1786433
concepts[5].display_name	Tumor microenvironment
concepts[6].id	https://openalex.org/C203014093
concepts[6].level	1
concepts[6].score	0.3838506042957306
concepts[6].wikidata	https://www.wikidata.org/wiki/Q101929
concepts[6].display_name	Immunology
concepts[7].id	https://openalex.org/C71924100
concepts[7].level	0
concepts[7].score	0.3794260025024414
concepts[7].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[7].display_name	Medicine
concepts[8].id	https://openalex.org/C2776090121
concepts[8].level	3
concepts[8].score	0.3575614094734192
concepts[8].wikidata	https://www.wikidata.org/wiki/Q193529
concepts[8].display_name	T cell
concepts[9].id	https://openalex.org/C126322002
concepts[9].level	1
concepts[9].score	0.18423756957054138
concepts[9].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[9].display_name	Internal medicine
concepts[10].id	https://openalex.org/C8891405
concepts[10].level	2
concepts[10].score	0.1666593849658966
concepts[10].wikidata	https://www.wikidata.org/wiki/Q1059
concepts[10].display_name	Immune system
concepts[11].id	https://openalex.org/C3020616263
concepts[11].level	2
concepts[11].score	0.15712875127792358
concepts[11].wikidata	https://www.wikidata.org/wiki/Q1216998
concepts[11].display_name	Tumor cells
keywords[0].id	https://openalex.org/keywords/triple-negative-breast-cancer
keywords[0].score	0.9147883653640747
keywords[0].display_name	Triple-negative breast cancer
keywords[1].id	https://openalex.org/keywords/cancer-research
keywords[1].score	0.6760543584823608
keywords[1].display_name	Cancer research
keywords[2].id	https://openalex.org/keywords/adoptive-cell-transfer
keywords[2].score	0.5316783785820007
keywords[2].display_name	Adoptive cell transfer
keywords[3].id	https://openalex.org/keywords/breast-cancer
keywords[3].score	0.5196996331214905
keywords[3].display_name	Breast cancer
keywords[4].id	https://openalex.org/keywords/cancer
keywords[4].score	0.5036844611167908
keywords[4].display_name	Cancer
keywords[5].id	https://openalex.org/keywords/tumor-microenvironment
keywords[5].score	0.4208592176437378
keywords[5].display_name	Tumor microenvironment
keywords[6].id	https://openalex.org/keywords/immunology
keywords[6].score	0.3838506042957306
keywords[6].display_name	Immunology
keywords[7].id	https://openalex.org/keywords/medicine
keywords[7].score	0.3794260025024414
keywords[7].display_name	Medicine
keywords[8].id	https://openalex.org/keywords/t-cell
keywords[8].score	0.3575614094734192
keywords[8].display_name	T cell
keywords[9].id	https://openalex.org/keywords/internal-medicine
keywords[9].score	0.18423756957054138
keywords[9].display_name	Internal medicine
keywords[10].id	https://openalex.org/keywords/immune-system
keywords[10].score	0.1666593849658966
keywords[10].display_name	Immune system
keywords[11].id	https://openalex.org/keywords/tumor-cells
keywords[11].score	0.15712875127792358
keywords[11].display_name	Tumor cells
language	en
locations[0].id	doi:10.1158/0008-5472.c.6510005
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/0008-5472.c.6510005
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5037851323
authorships[0].author.orcid	https://orcid.org/0000-0002-0272-8041
authorships[0].author.display_name	Tiara T. Byrd
authorships[0].author_position	first
authorships[0].raw_author_name	Tiara T. Byrd
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5076040364
authorships[1].author.orcid	https://orcid.org/0000-0002-2307-5000
authorships[1].author.display_name	Kristen Fousek
authorships[1].author_position	middle
authorships[1].raw_author_name	Kristen Fousek
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5001925175
authorships[2].author.orcid
authorships[2].author.display_name	Antonella Pignata
authorships[2].author_position	middle
authorships[2].raw_author_name	Antonella Pignata
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5063170825
authorships[3].author.orcid
authorships[3].author.display_name	Christopher Szot
authorships[3].author_position	middle
authorships[3].raw_author_name	Christopher Szot
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5000078250
authorships[4].author.orcid
authorships[4].author.display_name	Heba Samaha
authorships[4].author_position	middle
authorships[4].raw_author_name	Heba Samaha
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5068400345
authorships[5].author.orcid	https://orcid.org/0000-0003-3349-3334
authorships[5].author.display_name	Steven Seaman
authorships[5].author_position	middle
authorships[5].raw_author_name	Steven Seaman
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5044175725
authorships[6].author.orcid	https://orcid.org/0000-0001-6839-629X
authorships[6].author.display_name	Lacey E. Dobrolecki
authorships[6].author_position	middle
authorships[6].raw_author_name	Lacey Dobrolecki
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5068795319
authorships[7].author.orcid
authorships[7].author.display_name	Vita S. Salsman
authorships[7].author_position	middle
authorships[7].raw_author_name	Vita S. Salsman
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5051781768
authorships[8].author.orcid	https://orcid.org/0009-0009-8514-2713
authorships[8].author.display_name	Htoo Zarni Oo
authorships[8].author_position	middle
authorships[8].raw_author_name	Htoo Zarni Oo
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5000749732
authorships[9].author.orcid	https://orcid.org/0000-0003-0790-2931
authorships[9].author.display_name	Kevin Bielamowicz
authorships[9].author_position	middle
authorships[9].raw_author_name	Kevin Bielamowicz
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5010252154
authorships[10].author.orcid	https://orcid.org/0000-0002-1487-1136
authorships[10].author.display_name	Daniel Landi
authorships[10].author_position	middle
authorships[10].raw_author_name	Daniel Landi
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5003996137
authorships[11].author.orcid	https://orcid.org/0000-0002-6286-0095
authorships[11].author.display_name	Nino Rainusso
authorships[11].author_position	middle
authorships[11].raw_author_name	Nino Rainusso
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5109067868
authorships[12].author.orcid
authorships[12].author.display_name	John Hicks
authorships[12].author_position	middle
authorships[12].raw_author_name	John Hicks
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5103563787
authorships[13].author.orcid
authorships[13].author.display_name	Suzanne Z. Powell
authorships[13].author_position	middle
authorships[13].raw_author_name	Suzanne Powell
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5101198163
authorships[14].author.orcid
authorships[14].author.display_name	Matthew L. Baker
authorships[14].author_position	middle
authorships[14].raw_author_name	Matthew L. Baker
authorships[14].is_corresponding	False
authorships[15].author.id	https://openalex.org/A5059562009
authorships[15].author.orcid	https://orcid.org/0000-0001-9858-3643
authorships[15].author.display_name	Winfried S. Wels
authorships[15].author_position	middle
authorships[15].raw_author_name	Winfried S. Wels
authorships[15].is_corresponding	False
authorships[16].author.id	https://openalex.org/A5029950650
authorships[16].author.orcid	https://orcid.org/0000-0003-4164-9570
authorships[16].author.display_name	Joachim Koch
authorships[16].author_position	middle
authorships[16].raw_author_name	Joachim Koch
authorships[16].is_corresponding	False
authorships[17].author.id	https://openalex.org/A5083608565
authorships[17].author.orcid	https://orcid.org/0000-0001-7447-2199
authorships[17].author.display_name	Poul H. Sorensen
authorships[17].author_position	middle
authorships[17].raw_author_name	Poul H. Sorensen
authorships[17].is_corresponding	False
authorships[18].author.id	https://openalex.org/A5060953418
authorships[18].author.orcid	https://orcid.org/0000-0002-6335-1081
authorships[18].author.display_name	Benjamin Deneen
authorships[18].author_position	middle
authorships[18].raw_author_name	Benjamin Deneen
authorships[18].is_corresponding	False
authorships[19].author.id	https://openalex.org/A5057135409
authorships[19].author.orcid	https://orcid.org/0000-0002-8467-8534
authorships[19].author.display_name	Matthew J. Ellis
authorships[19].author_position	middle
authorships[19].raw_author_name	Matthew J. Ellis
authorships[19].is_corresponding	False
authorships[20].author.id	https://openalex.org/A5037254064
authorships[20].author.orcid	https://orcid.org/0000-0002-6330-4007
authorships[20].author.display_name	Michael T. Lewis
authorships[20].author_position	middle
authorships[20].raw_author_name	Michael T. Lewis
authorships[20].is_corresponding	False
authorships[21].author.id	https://openalex.org/A5032050779
authorships[21].author.orcid	https://orcid.org/0000-0002-7778-7871
authorships[21].author.display_name	Meenakshi Hegde
authorships[21].author_position	middle
authorships[21].raw_author_name	Meenakshi Hegde
authorships[21].is_corresponding	False
authorships[22].author.id	https://openalex.org/A5109855770
authorships[22].author.orcid
authorships[22].author.display_name	Bradley S. Fletcher
authorships[22].author_position	middle
authorships[22].raw_author_name	Bradley S. Fletcher
authorships[22].is_corresponding	False
authorships[23].author.id	https://openalex.org/A5055104705
authorships[23].author.orcid	https://orcid.org/0000-0002-6246-0374
authorships[23].author.display_name	Brad St. Croix
authorships[23].author_position	middle
authorships[23].raw_author_name	Brad St. Croix
authorships[23].is_corresponding	False
authorships[24].author.id	https://openalex.org/A5029941019
authorships[24].author.orcid	https://orcid.org/0000-0002-0982-8424
authorships[24].author.display_name	Nabil Ahmed
authorships[24].author_position	last
authorships[24].raw_author_name	Nabil Ahmed
authorships[24].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1158/0008-5472.c.6510005
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Data from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T11491
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9998000264167786
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2730
primary_topic.subfield.display_name	Oncology
primary_topic.display_name	CAR-T cell therapy research
related_works	https://openalex.org/W4362432751, https://openalex.org/W3030228103, https://openalex.org/W2903919886, https://openalex.org/W2064898491, https://openalex.org/W4388541371, https://openalex.org/W2312355201, https://openalex.org/W2117246658, https://openalex.org/W1986496754, https://openalex.org/W2738153741, https://openalex.org/W4317738354
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1158/0008-5472.c.6510005
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/0008-5472.c.6510005
primary_location.id	doi:10.1158/0008-5472.c.6510005
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/0008-5472.c.6510005
publication_date	2023-03-31
publication_year	2023
referenced_works_count	0
abstract_inverted_index.T	18, 45, 73, 88, 95
abstract_inverted_index.a	16, 25, 134, 145, 153
abstract_inverted_index.In	11
abstract_inverted_index.an	5, 162
abstract_inverted_index.as	63, 65, 105, 107, 144
abstract_inverted_index.be	40
abstract_inverted_index.by	115
abstract_inverted_index.in	32, 42, 168
abstract_inverted_index.is	4, 166
abstract_inverted_index.of	53, 83, 92, 99, 137, 142, 156, 161
abstract_inverted_index.on	29
abstract_inverted_index.to	22, 39, 86, 127, 147
abstract_inverted_index.we	14
abstract_inverted_index.CAR	17, 44, 72, 94
abstract_inverted_index.Our	131
abstract_inverted_index.and	58, 122, 172
abstract_inverted_index.for	139, 158
abstract_inverted_index.the	70, 81, 124, 173
abstract_inverted_index.was	36
abstract_inverted_index.Res;	178
abstract_inverted_index.TEM8	54, 71, 93, 143
abstract_inverted_index.TNBC	67, 110, 119
abstract_inverted_index.both	116
abstract_inverted_index.cell	111
abstract_inverted_index.lung	108
abstract_inverted_index.that	35, 49, 165
abstract_inverted_index.this	12
abstract_inverted_index.upon	50
abstract_inverted_index.well	64, 106
abstract_inverted_index.were	47
abstract_inverted_index.TEM8,	24
abstract_inverted_index.TNBC.	43
abstract_inverted_index.These	150
abstract_inverted_index.block	128
abstract_inverted_index.cells	31, 46, 62, 74, 96, 121
abstract_inverted_index.colon	33
abstract_inverted_index.offer	133, 152
abstract_inverted_index.proof	136, 155
abstract_inverted_index.treat	148
abstract_inverted_index.tumor	60, 120, 125, 129, 175
abstract_inverted_index.(TNBC)	3
abstract_inverted_index.78(2);	179
abstract_inverted_index.breast	1, 76, 170
abstract_inverted_index.cancer	2, 77, 171
abstract_inverted_index.cells,	79
abstract_inverted_index.cells.	68, 89
abstract_inverted_index.killed	59
abstract_inverted_index.marker	26
abstract_inverted_index.study,	13
abstract_inverted_index.target	23
abstract_inverted_index.tumors	34
abstract_inverted_index.©2017	181
abstract_inverted_index.antigen	164
abstract_inverted_index.concept	138, 157
abstract_inverted_index.defined	28
abstract_inverted_index.disease	7
abstract_inverted_index.induced	97
abstract_inverted_index.killing	117
abstract_inverted_index.lacking	8
abstract_inverted_index.tumors,	104, 114
abstract_inverted_index.Adoptive	90
abstract_inverted_index.Notably,	69
abstract_inverted_index.findings	132, 151
abstract_inverted_index.recently	38
abstract_inverted_index.relative	85
abstract_inverted_index.secreted	55
abstract_inverted_index.specific	51
abstract_inverted_index.strategy	21, 146
abstract_inverted_index.targeted	9, 75
abstract_inverted_index.therapy.	10
abstract_inverted_index.transfer	91
abstract_inverted_index.cytokines	57
abstract_inverted_index.developed	15, 48
abstract_inverted_index.formation	82
abstract_inverted_index.initially	27
abstract_inverted_index.localized	101
abstract_inverted_index.targeting	123, 141, 160
abstract_inverted_index.xenograft	103, 113
abstract_inverted_index.489–500.	180
abstract_inverted_index.aggressive	6
abstract_inverted_index.associated	174
abstract_inverted_index.discovered	37
abstract_inverted_index.metastatic	109
abstract_inverted_index.offsetting	80
abstract_inverted_index.regression	98
abstract_inverted_index.endothelial	30, 61, 163
abstract_inverted_index.endothelium	126
abstract_inverted_index.preclinical	135, 154
abstract_inverted_index.recognition	52
abstract_inverted_index.stem–like	78
abstract_inverted_index.upregulated	41
abstract_inverted_index.cell–based	19
abstract_inverted_index.established,	100
abstract_inverted_index.mammospheres	84
abstract_inverted_index.vasculature.	176
abstract_inverted_index.TEM8-positive	66
abstract_inverted_index.nontransduced	87
abstract_inverted_index.overexpressed	167
abstract_inverted_index.line–derived	112
abstract_inverted_index.<i>Cancer	177
abstract_inverted_index.patient-derived	102
abstract_inverted_index.triple-negative	169
abstract_inverted_index.immunostimulatory	56
abstract_inverted_index.immunotherapeutic	20, 140, 159
abstract_inverted_index.neovascularization.	130
abstract_inverted_index.TEM8<sup>+</sup>	118
abstract_inverted_index.AACR</i>.</p></div>	182
abstract_inverted_index.<div>Abstract<p>Triple-negative	0
abstract_inverted_index.TNBC.</p><p><b>Significance:</b>	149
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	25
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.7900000214576721
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.1031569
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False