Data from The ARF Tumor Suppressor Can Promote the Progression of Some Tumors Article Swipe

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Olivier Humbey , Julia Pimkina , Jack T. Zilfou , Michal Jarník , Carmen Dominguez‐Brauer , Darren J. Burgess , Christine M. Eischen , Maureen E. Murphy ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/0008-5472.c.6498023

p14/p19^ARF (ARF) is a tumor suppressor gene that is frequently mutated in human cancer. ARF has multiple tumor suppressor functions, some of which are mediated by signaling to p53. Surprisingly, a significant fraction of human tumors retain persistently high levels of ARF, suggesting that ARF may possess a prosurvival function. We show that ARF protein is markedly up-regulated in cells exposed to nutrient starvation. Cells with silenced ARF show reduced autophagy and reduced viability when placed under conditions of starvation. We show for the first time that ARF silencing can limit the progression of some tumors, such as lymphoma, but not others, such as E1A/Ras-induced tumors. Specifically, myc-driven lymphomas with mutant p53 tend to overexpress ARF; we show that silencing ARF in these tumors greatly impedes their progression. These data are the first to show that ARF can act in a p53-independent manner to promote the progression of some tumors. [Cancer Res 2008;68(23):9608–13]

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Suppressor Cancer research Tumor progression Medicine Oncology Political science Internal medicine Cancer

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/0008-5472.c.6498023
OA Status: gold
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DOI: https://doi.org/10.1158/0008-5472.c.6498023

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Title: Data from The ARF Tumor Suppressor Can Promote the Progression of Some Tumors

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Type: preprint

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Language: en

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Publication year: 2023

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Publication date: 2023-03-30

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Authors: Olivier Humbey, Julia Pimkina, Jack T. Zilfou, Michal Jarník, Carmen Dominguez‐Brauer, Darren J. Burgess, Christine M. Eischen, Maureen E. Murphy

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Landing page: https://doi.org/10.1158/0008-5472.c.6498023

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OA URL: https://doi.org/10.1158/0008-5472.c.6498023

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Concepts: Suppressor, Cancer research, Tumor progression, Medicine, Oncology, Political science, Internal medicine, Cancer

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Cited by: 0

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Related works (count): 10

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