Data Supplement from Bioactive Lipids, LPC and LPA, Are Novel Prometastatic Factors and Their Tissue Levels Increase in Response to Radio/Chemotherapy Article Swipe

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Gabriela Schneider , Zachariah Payne Sellers , Ahmed Abdel‐Latif , Andrew J. Morris , Mariusz Z. Ratajczak ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1541-7786.22511571.v1

Supplementary Figure 3. Ki16425 is not toxic against RMS cells. Panel E and F - Images of cells that were incubated in the absence (vehicle) or presence of Ki16425. Panel E - cells incubated with medium supplemented with 10% FBS, Panel F - cells incubated in medium supplemented with 0.5% BSA. Representative images are shown. Panel G - Chemotaxis to LPA of RH30 cells pretreated for 1h with 10 μM Ki16425 Results are presented as a percentage Ki16425. of cells migrating to LPA gradient as compared to control cells pretreated with vehicle only. Based on fact that chemotaxis assay was run for 24 hours, exposure of RMS cells to Ki16425 significantly affect responsiveness of RMS cells to LPA for at least 36 hours [24 hours (time of assay) + 12 hours (cells kept in culture before performing assay)]. The recovery of responsiveness to LPA gradient after 24 hours indicates transient but not toxic effect of Ki16425.

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Chemotaxis Andrology Chemistry Medicine Biochemistry Receptor

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Language: en
Landing Page: https://doi.org/10.1158/1541-7786.22511571.v1
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DOI: https://doi.org/10.1158/1541-7786.22511571.v1

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Title: Data Supplement from Bioactive Lipids, LPC and LPA, Are Novel Prometastatic Factors and Their Tissue Levels Increase in Response to Radio/Chemotherapy

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Type: preprint

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Language: en

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Publication year: 2023

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Authors: Gabriela Schneider, Zachariah Payne Sellers, Ahmed Abdel‐Latif, Andrew J. Morris, Mariusz Z. Ratajczak

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Landing page: https://doi.org/10.1158/1541-7786.22511571.v1

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Concepts: Chemotaxis, Andrology, Chemistry, Medicine, Biochemistry, Receptor

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