Database Bias in the Detection of Interdomain Horizontal Gene Transfer Events in Pezizomycotina Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.3390/biology13070469
Horizontal gene transfer (HGT) is a widely acknowledged phenomenon in prokaryotes for generating genetic diversity. However, the impact of this process in eukaryotes, particularly interdomain HGT, is a topic of debate. Although there have been observed biases in interdomain HGT detection, little exploration has been conducted on the effects of imbalanced databases. In our study, we conducted experiments to assess how different databases affect the detection of interdomain HGT using proteomes from the Pezizomycotina fungal subphylum as our focus group. Our objective was to simulate the database imbalance commonly found in public biological databases, where bacterial and eukaryotic sequences are unevenly represented, and demonstrate that an increase in uploaded eukaryotic sequences leads to a decrease in predicted HGTs. For our experiments, four databases with varying proportions of eukaryotic sequences but consistent proportions of bacterial sequences were utilized. We observed a significant reduction in detected interdomain HGT candidates as the proportion of eukaryotes increased within the database. Our data suggest that the imbalance in databases bias the interdomain HGT detection and highlights challenges associated with confirming the presence of interdomain HGT among Pezizomycotina fungi and potentially other groups within Eukarya.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biology13070469
- https://www.mdpi.com/2079-7737/13/7/469/pdf?version=1719385243
- OA Status
- gold
- Cited By
- 1
- References
- 34
- Related Works
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- OpenAlex ID
- https://openalex.org/W4400040133
Raw OpenAlex JSON
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https://openalex.org/W4400040133Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/biology13070469Digital Object Identifier
- Title
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Database Bias in the Detection of Interdomain Horizontal Gene Transfer Events in PezizomycotinaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-26Full publication date if available
- Authors
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Kevin Aguirre-Carvajal, Cristian R. Munteanu, Vinicio Armijos‐JaramilloList of authors in order
- Landing page
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https://doi.org/10.3390/biology13070469Publisher landing page
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https://www.mdpi.com/2079-7737/13/7/469/pdf?version=1719385243Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2079-7737/13/7/469/pdf?version=1719385243Direct OA link when available
- Concepts
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Horizontal gene transfer, Biology, Database, Gene, Genetics, Prokaryote, Evolutionary biology, Phylogenetics, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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