Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry Article Swipe
Manuel David Peris‐Díaz
,
Artur Krężel
,
Perdita E. Barran
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s42004-024-01395-w
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s42004-024-01395-w
The transcription factor p53 is exquisitely sensitive and selective to a broad variety of cellular environments. Several studies have reported that oxidative stress weakens the p53-DNA binding affinity for certain promoters depending on the oxidation mechanism. Despite this body of work, the precise mechanisms by which the physiologically relevant DNA-p53 tetramer complex senses cellular stresses caused by H 2 O 2 are still unknown. Here, we employed native mass spectrometry (MS) and ion mobility (IM)-MS coupled to chemical labelling and H 2 O 2 -induced oxidation to examine the mechanism of redox regulation of the p53- p21 complex. Our approach has found that two reactive cysteines in p53 protect against H 2 O 2 -induced oxidation by forming reversible sulfenates.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s42004-024-01395-w
- https://www.nature.com/articles/s42004-024-01395-w.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 121
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406385333
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406385333Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s42004-024-01395-wDigital Object Identifier
- Title
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Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometryWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-15Full publication date if available
- Authors
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Manuel David Peris‐Díaz, Artur Krężel, Perdita E. BarranList of authors in order
- Landing page
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https://doi.org/10.1038/s42004-024-01395-wPublisher landing page
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https://www.nature.com/articles/s42004-024-01395-w.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s42004-024-01395-w.pdfDirect OA link when available
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Mass spectrometry, Safeguarding, Cysteine, Chemistry, High resolution, Chromatography, Environmental chemistry, Biochemistry, Geography, Remote sensing, Medicine, Nursing, EnzymeTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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121Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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