Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown Article Swipe
Matthew S. Brook
,
Tanner Stokes
,
Stefan H.M. Gorissen
,
Joseph J. Bass
,
Chris McGlory
,
Jessica Cegielski
,
Daniel J. Wilkinson
,
Bethan E. Phillips
,
Kenneth Smith
,
Stuart M. Phillips
,
Philip J. Atherton
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jcsm.13005
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jcsm.13005
Background We determined the short‐term (i.e. 4 days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted‐fed muscle protein synthesis (MPS)/muscle protein breakdown (MPB) and integrated MPS/estimated MPB]. Methods Healthy men ( N = 9, 22 ± 2 years, body mass index 24 ± 3 kg m −2 ) underwent 4 day unilateral leg immobilization. Vastus lateralis (VL) muscle thickness (MT) and extensor strength and thigh lean mass (TLM) were measured. Bilateral VL muscle biopsies were collected on Day 4 at t = −120, 0, 90, and 180 min to determine integrated MPS, estimated MPB, acute fasted‐fed MPS ( l ‐[ring‐ 13 C 6 ]‐phe), and acute fasted tracer decay rate representative of MPB ( l ‐[ 15 N]‐phe and l ‐[ 2 H 8 ]‐phe). Protein turnover cell signalling was measured by immunoblotting. Results Immobilization decreased TLM [pre: 7477 ± 1196 g, post: 7352 ± 1209 g ( P < 0.01)], MT [pre: 2.67 ± 0.50 cm, post: 2.55 ± 0.51 cm ( P < 0.05)], and strength [pre: 260 ± 43 N m, post: 229 ± 37 N m ( P < 0.05)] with no change in control legs. Integrated MPS decreased in immob vs. control legs [control: 1.55 ± 0.21% day −1 , immob: 1.29 ± 0.17% day −1 ( P < 0.01)], while tracer decay rate (i.e. MPB) (control: 0.02 ± 0.006, immob: 0.015 ± 0.015) and fractional breakdown rate (FBR) remained unchanged [control: 1.44 ± 0.51% day −1 , immob: 1.73 ± 0.35% day −1 ( P = 0.21)]. Changes in MT correlated with those in MPS but not FBR. MPS increased in the control leg following feeding [fasted: 0.043 ± 0.012% h −1 , fed: 0.065 ± 0.017% h −1 ( P < 0.05)] but not in immob [fasted: 0.034 ± 0.014% h −1 , fed: 0.049 ± 0.023% h −1 ( P = 0.09)]. There were no changes in markers of MPB with immob ( P > 0.05). Conclusions Human skeletal muscle disuse atrophy is driven by declines in MPS, not increases in MPB. Pro‐anabolic therapies to mitigate disuse atrophy would likely be more effective than therapies aimed at attenuating protein degradation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jcsm.13005
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcsm.13005
- OA Status
- gold
- Cited By
- 59
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281388555
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281388555Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jcsm.13005Digital Object Identifier
- Title
-
Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdownWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-23Full publication date if available
- Authors
-
Matthew S. Brook, Tanner Stokes, Stefan H.M. Gorissen, Joseph J. Bass, Chris McGlory, Jessica Cegielski, Daniel J. Wilkinson, Bethan E. Phillips, Kenneth Smith, Stuart M. Phillips, Philip J. AthertonList of authors in order
- Landing page
-
https://doi.org/10.1002/jcsm.13005Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcsm.13005Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcsm.13005Direct OA link when available
- Concepts
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Medicine, Muscle atrophy, Internal medicine, Endocrinology, Lean body mass, Sarcopenia, Atrophy, Protein turnover, Muscle mass, Protein biosynthesis, Chemistry, Biochemistry, Body weightTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
59Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 17, 2024: 23, 2023: 15, 2022: 4Per-year citation counts (last 5 years)
- References (count)
-
50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| primary_location.source.display_name | Journal of Cachexia Sarcopenia and Muscle |
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| primary_location.license | cc-by |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcsm.13005 |
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| primary_location.raw_source_name | Journal of Cachexia, Sarcopenia and Muscle |
| primary_location.landing_page_url | https://doi.org/10.1002/jcsm.13005 |
| publication_date | 2022-05-23 |
| publication_year | 2022 |
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