Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model Article Swipe

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Anouk Sesink , R. Geyer , P Devanand , Till T. Böhlen , Luca Soutter , Raphaël Moeckli , Claude Bailat , Fernanda Herrera , Veljko Grilj ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.radonc.2025.111262

In an acute responding model of radiation-induced abdominal toxicity, the FLASH sparing effect was substantially reduced with a two-fraction regimen and completely absent with a ten-fraction regimen. These findings suggest that the benefit of FLASH may be limited at lower doses per fraction and highlight the need for further studies in other clinically relevant models to better define the boundaries of its therapeutic applicability.

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Landing Page: https://doi.org/10.1016/j.radonc.2025.111262
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Title: Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model

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Publication year: 2025

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Authors: Anouk Sesink, R. Geyer, P Devanand, Till T. Böhlen, Luca Soutter, Raphaël Moeckli, Claude Bailat, Fernanda Herrera, Veljko Grilj

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Landing page: https://doi.org/10.1016/j.radonc.2025.111262

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abstract_inverted_index.two-fraction	18
abstract_inverted_index.substantially	14
abstract_inverted_index.applicability.	63
abstract_inverted_index.radiation-induced	6
cited_by_percentile_year
countries_distinct_count	1
institutions_distinct_count	9
citation_normalized_percentile