Decreased embryo developmental potential and lower cumulative pregnancy rate in men with multiple morphological abnormalities of the sperm flagella Article Swipe
Rui Long
,
Meng Wang
,
Juepu Zhou
,
Ruolin Mao
,
Cheng Wang
,
Longjie Gu
,
Yinwei Chen
,
Lei Jin
,
Lixia Zhu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2024.1377780
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2024.1377780
Objective Multiple morphological abnormalities of the sperm flagella (MMAF) is characterized by abnormal flagellar phenotypes, which is a particular kind of asthenoteratozoospermia. Previous studies have reported a comparable intracytoplasmic sperm injection (ICSI) outcome in terms of fertilization rate and clinical pregnancy rate in patients with MMAF compared with those with no MMAF; however, others have conflicting opinions. Assisted reproductive technology (ART) outcomes in individuals with MMAF are still controversial and open to debate. Methods A total of 38 patients with MMAF treated at an academic reproductive center between January 2014 and July 2022 were evaluated in the current retrospective cohort study and followed up until January 2023. Propensity score matching was used to adjust for the baseline clinical characteristics of the patients and to create a comparable control group. The genetic pathogenesis of MMAF was confirmed by whole exome sequencing. The main outcomes were the embryo developmental potential, the cumulative pregnancy rate (CLPR), and the cumulative live birth rate (CLBR). Results Pathogenic variants in known genes of DNAH1 , DNAH11 , CFAP43 , FSIP2 , and SPEF2 were identified in patients with MMAF. Laboratory outcomes, including the fertilization rate, 2PN cleavage rate, blastocyst formation rate, and available blastocyst rate, followed a trend of decline in the MMAF group ( p < 0.05). Moreover, according to the embryo transfer times and complete cycles, the CLPR in the cohort of MMAF was lower compared with the oligoasthenospermia pool ( p = 0.033 and p = 0.020, respectively), while no statistical differences were observed in the neonatal outcomes. Conclusion The current study presented decreased embryo developmental potential and compromised clinical outcomes in the MMAF cohort. These findings may provide clinicians with evidence to support genetic counseling and clinical guidance in specific patients with MMAF.
Related Topics
Concepts
Intracytoplasmic sperm injection
Embryo
Andrology
Blastocyst
Sperm
Live birth
Pregnancy rate
Embryo transfer
Assisted reproductive technology
Pregnancy
Human fertilization
Biology
In vitro fertilisation
Medicine
Obstetrics
Gynecology
Infertility
Genetics
Embryogenesis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2024.1377780
- OA Status
- gold
- Cited By
- 6
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396570078
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396570078Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2024.1377780Digital Object Identifier
- Title
-
Decreased embryo developmental potential and lower cumulative pregnancy rate in men with multiple morphological abnormalities of the sperm flagellaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-30Full publication date if available
- Authors
-
Rui Long, Meng Wang, Juepu Zhou, Ruolin Mao, Cheng Wang, Longjie Gu, Yinwei Chen, Lei Jin, Lixia ZhuList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2024.1377780Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fendo.2024.1377780Direct OA link when available
- Concepts
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Intracytoplasmic sperm injection, Embryo, Andrology, Blastocyst, Sperm, Live birth, Pregnancy rate, Embryo transfer, Assisted reproductive technology, Pregnancy, Human fertilization, Biology, In vitro fertilisation, Medicine, Obstetrics, Gynecology, Infertility, Genetics, EmbryogenesisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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