Decreased risk of nosocomial transmission of hepatitis B and C viruses among hemodialysis patients in Southern Bulgaria Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.3855/jidc.20035
Introduction: Hepatitis B (HBV) and (HCV) virus infections represent a nosocomial risk in hemodialysis (HD) patients. We aimed to evaluate the risk among adult HD patients in southern Bulgaria. Methodology: A prospective cohort study included 225 patients from three HD centers between January 2020 and June 2022. HBV and HCV infections were characterized by serological and virological markers determined through enzyme-linked immunosorbent assay and polymerase chain reaction. Results: HBV infection was detected in 13 patients and HCV in 15. Ten of the hepatitis patients died of non-liver-related complications. Sustained virological response (SVR) was confirmed in five HCV-infected patients previously cured with direct-acting antivirals (DAAs). Five patients were viremic. Three of them achieved SVR after DAAs, and two refused treatments. A decrease in HCV viremia prevalence (2.22% versus 0.89%) was recorded (p = 0.15). Virological suppression was confirmed in four HBV-infected patients treated with nucleos(t)ide analogs. Тwo patients were not eligible for antivirals. Decreased HBV viremia prevalence (2.7% versus 0.89%) was recorded (p = 0.15). Among HBV surface antigen (HBsAg)-negative patients, HBV vaccination coverage was 62.74% (133/212) and higher in 2 HD centers (128/137; 93.43%). Nevertheless, one-third of participants (34/112; 30.36%) were susceptible to HBV. Twenty-four vaccinees (24/112; 21.43%) had acquired natural immunity but remained at risk of reactivation in case of immunosuppression. HBV DNA was detected in eight HBsAg-negative patients, resulting in a prevalence of 7.14% (8/112) for occult HBV infection. Conclusions: The study reveals a downward trend in HBV and HCV viremia prevalence among HD patients. To further reduce the risk of nosocomial transmission, vaccination for hepatitis B requires updating.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3855/jidc.20035
- https://www.jidc.org/index.php/journal/article/download/40452540/3660
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4410969992Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3855/jidc.20035Digital Object Identifier
- Title
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Decreased risk of nosocomial transmission of hepatitis B and C viruses among hemodialysis patients in Southern BulgariaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-05-31Full publication date if available
- Authors
-
R. Komitova, Elitsa Golkocheva‐Markova, Аni Kevorkyan, Lubomira Nikolaeva–Glomb, Vanya Rangelova, Tanya I Kostadinova, Tsvetelina Chardakova, M. Atanasova, Tencho Tenev, G Kiprin, Simon K Sariyan, Ralitsa Raycheva, Valeri TzekovList of authors in order
- Landing page
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https://doi.org/10.3855/jidc.20035Publisher landing page
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https://www.jidc.org/index.php/journal/article/download/40452540/3660Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.jidc.org/index.php/journal/article/download/40452540/3660Direct OA link when available
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Medicine, HBsAg, Viremia, Internal medicine, Hepatitis B virus, Serology, Transmission (telecommunications), Virology, Immunosuppression, Hemodialysis, Hepatitis B, Gastroenterology, Immunology, Antibody, Virus, Engineering, Electrical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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