Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia Article Swipe
Taotao Liang
,
Xiaojiao Wang
,
Yanyan Liu
,
Hao Ai
,
Qian Wang
,
Xianwei Wang
,
Xudong Wei
,
Yongping Song
,
Qingsong Yin
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.985280
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.985280
T cell immune dysfunction is a prominent characteristic of chronic lymphocytic leukemia (CLL) and the main cause of failure for immunotherapy and multi-drug resistance. There remains a lack of specific biomarkers for evaluating T cell immune status with outcome for CLL patients. T cell factor 1 (TCF1, encoded by the TCF7 gene) can be used as a critical determinant of successful anti-tumor immunotherapy and a prognostic indicator in some solid tumors; however, the effects of TCF1 in CLL remain unclear. Here, we first analyzed the biological processes and functions of TCF1 and co-expressing genes using the GEO and STRING databases with the online tools Venny, Circos, and Database for Annotation, Visualization, and Integrated Discovery (DAVID). Then the expression and prognostic values of TCF1 and its partner gene B cell leukemia/lymphoma 11B (BCL11B) were explored for 505 CLL patients from 6 datasets and validated with 50 CLL patients from Henan cancer hospital (HNCH). TCF1 was downregulated in CLL patients, particularly in CD8+ T cells, which was significantly correlated with poor time-to-first treatment (TTFT) and overall survival (OS) as well as short restricted mean survival time (RMST). Function and pathway enrichment analysis revealed that TCF1 was positively correlated with BCL11B, which is involved in regulating the activation and differentiation of T cells in CLL patients. Intriguingly, BCL11B was highly consistent with TCF1 in its decreased expression and prediction of poor prognosis. More importantly, the combination of TCF1 and BCL11B could more accurately assess prognosis than either alone. Additionally, decreased TCF1 and BCL11B expression serves as an independent risk factor for rapid disease progression, coinciding with high-risk indicators, including unmutated IGHV, TP53 alteration, and advanced disease. Altogether, this study demonstrates that decreased TCF1 and BCL11B expression is significantly correlated with poor prognosis, which may be due to decreased TCF1+CD8+ T cells, impairing the effector CD8+ T cell differentiation regulated by TCF1/BCL11B.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2022.985280
- OA Status
- gold
- Cited By
- 6
- References
- 47
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4296828206Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2022.985280Digital Object Identifier
- Title
-
Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemiaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-09-23Full publication date if available
- Authors
-
Taotao Liang, Xiaojiao Wang, Yanyan Liu, Hao Ai, Qian Wang, Xianwei Wang, Xudong Wei, Yongping Song, Qingsong YinList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2022.985280Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fimmu.2022.985280Direct OA link when available
- Concepts
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Chronic lymphocytic leukemia, CD8, Immunotherapy, Immune system, Cancer research, Cancer, Oncology, Medicine, T cell, Internal medicine, Leukemia, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 3Per-year citation counts (last 5 years)
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.cause | 16 |
| abstract_inverted_index.cells | 209 |
| abstract_inverted_index.could | 237 |
| abstract_inverted_index.first | 82 |
| abstract_inverted_index.gene) | 51 |
| abstract_inverted_index.genes | 93 |
| abstract_inverted_index.rapid | 258 |
| abstract_inverted_index.short | 179 |
| abstract_inverted_index.solid | 69 |
| abstract_inverted_index.study | 275 |
| abstract_inverted_index.tools | 103 |
| abstract_inverted_index.using | 94 |
| abstract_inverted_index.which | 163, 198, 289 |
| abstract_inverted_index.(TCF1, | 46 |
| abstract_inverted_index.(TTFT) | 171 |
| abstract_inverted_index.BCL11B | 214, 236, 249, 281 |
| abstract_inverted_index.STRING | 98 |
| abstract_inverted_index.Venny, | 104 |
| abstract_inverted_index.alone. | 244 |
| abstract_inverted_index.assess | 240 |
| abstract_inverted_index.cancer | 149 |
| abstract_inverted_index.cells, | 162, 297 |
| abstract_inverted_index.either | 243 |
| abstract_inverted_index.factor | 44, 256 |
| abstract_inverted_index.highly | 216 |
| abstract_inverted_index.immune | 2, 35 |
| abstract_inverted_index.online | 102 |
| abstract_inverted_index.remain | 78 |
| abstract_inverted_index.serves | 251 |
| abstract_inverted_index.status | 36 |
| abstract_inverted_index.values | 120 |
| abstract_inverted_index.(HNCH). | 151 |
| abstract_inverted_index.(RMST). | 184 |
| abstract_inverted_index.BCL11B, | 197 |
| abstract_inverted_index.Circos, | 105 |
| abstract_inverted_index.chronic | 9 |
| abstract_inverted_index.disease | 259 |
| abstract_inverted_index.effects | 73 |
| abstract_inverted_index.encoded | 47 |
| abstract_inverted_index.failure | 18 |
| abstract_inverted_index.outcome | 38 |
| abstract_inverted_index.overall | 173 |
| abstract_inverted_index.partner | 125 |
| abstract_inverted_index.pathway | 187 |
| abstract_inverted_index.remains | 25 |
| abstract_inverted_index.tumors; | 70 |
| abstract_inverted_index.(BCL11B) | 131 |
| abstract_inverted_index.(DAVID). | 114 |
| abstract_inverted_index.Database | 107 |
| abstract_inverted_index.Function | 185 |
| abstract_inverted_index.advanced | 271 |
| abstract_inverted_index.analysis | 189 |
| abstract_inverted_index.analyzed | 83 |
| abstract_inverted_index.critical | 57 |
| abstract_inverted_index.datasets | 140 |
| abstract_inverted_index.disease. | 272 |
| abstract_inverted_index.effector | 300 |
| abstract_inverted_index.explored | 133 |
| abstract_inverted_index.hospital | 150 |
| abstract_inverted_index.however, | 71 |
| abstract_inverted_index.involved | 200 |
| abstract_inverted_index.leukemia | 11 |
| abstract_inverted_index.patients | 137, 146 |
| abstract_inverted_index.revealed | 190 |
| abstract_inverted_index.specific | 29 |
| abstract_inverted_index.survival | 174, 182 |
| abstract_inverted_index.unclear. | 79 |
| abstract_inverted_index.Discovery | 113 |
| abstract_inverted_index.TCF1+CD8+ | 295 |
| abstract_inverted_index.databases | 99 |
| abstract_inverted_index.decreased | 222, 246, 278, 294 |
| abstract_inverted_index.functions | 88 |
| abstract_inverted_index.high-risk | 263 |
| abstract_inverted_index.impairing | 298 |
| abstract_inverted_index.including | 265 |
| abstract_inverted_index.indicator | 66 |
| abstract_inverted_index.patients, | 157 |
| abstract_inverted_index.patients. | 41, 212 |
| abstract_inverted_index.processes | 86 |
| abstract_inverted_index.prognosis | 241 |
| abstract_inverted_index.prominent | 6 |
| abstract_inverted_index.regulated | 305 |
| abstract_inverted_index.treatment | 170 |
| abstract_inverted_index.unmutated | 266 |
| abstract_inverted_index.validated | 142 |
| abstract_inverted_index.Integrated | 112 |
| abstract_inverted_index.accurately | 239 |
| abstract_inverted_index.activation | 204 |
| abstract_inverted_index.anti-tumor | 61 |
| abstract_inverted_index.biological | 85 |
| abstract_inverted_index.biomarkers | 30 |
| abstract_inverted_index.coinciding | 261 |
| abstract_inverted_index.consistent | 217 |
| abstract_inverted_index.correlated | 166, 195, 285 |
| abstract_inverted_index.enrichment | 188 |
| abstract_inverted_index.evaluating | 32 |
| abstract_inverted_index.expression | 117, 223, 250, 282 |
| abstract_inverted_index.multi-drug | 22 |
| abstract_inverted_index.positively | 194 |
| abstract_inverted_index.prediction | 225 |
| abstract_inverted_index.prognosis, | 288 |
| abstract_inverted_index.prognosis. | 228 |
| abstract_inverted_index.prognostic | 65, 119 |
| abstract_inverted_index.regulating | 202 |
| abstract_inverted_index.restricted | 180 |
| abstract_inverted_index.successful | 60 |
| abstract_inverted_index.Altogether, | 273 |
| abstract_inverted_index.Annotation, | 109 |
| abstract_inverted_index.alteration, | 269 |
| abstract_inverted_index.combination | 232 |
| abstract_inverted_index.determinant | 58 |
| abstract_inverted_index.dysfunction | 3 |
| abstract_inverted_index.independent | 254 |
| abstract_inverted_index.indicators, | 264 |
| abstract_inverted_index.lymphocytic | 10 |
| abstract_inverted_index.resistance. | 23 |
| abstract_inverted_index.TCF1/BCL11B. | 307 |
| abstract_inverted_index.demonstrates | 276 |
| abstract_inverted_index.importantly, | 230 |
| abstract_inverted_index.particularly | 158 |
| abstract_inverted_index.progression, | 260 |
| abstract_inverted_index.Additionally, | 245 |
| abstract_inverted_index.Intriguingly, | 213 |
| abstract_inverted_index.co-expressing | 92 |
| abstract_inverted_index.downregulated | 154 |
| abstract_inverted_index.immunotherapy | 20, 62 |
| abstract_inverted_index.significantly | 165, 284 |
| abstract_inverted_index.time-to-first | 169 |
| abstract_inverted_index.Visualization, | 110 |
| abstract_inverted_index.characteristic | 7 |
| abstract_inverted_index.differentiation | 206, 304 |
| abstract_inverted_index.leukemia/lymphoma | 129 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5112529609 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I38877650, https://openalex.org/I4210143608 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5299999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.76885066 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |