Defining the role of 12-lipoxygenase in regulating platelet-derived extracellular vesicles Article Swipe
Alexis J Matthew
,
Jaël D Richard
,
Vanessa L. Gauvin
,
Mathieu P.A. Hébert
,
Mohamed Touaibia
,
Éric P. Allain
,
Luc H. Boudreau
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.bcp.2025.117404
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.bcp.2025.117404
Platelets are traditionally recognized for their role in hemostasis and wound repair, yet they also play a pivotal role in intercellular communication through the release of platelet-derived extracellular vesicles (PMVs). These vesicles contribute to diverse physiological and pathological processes, but the mechanisms governing their biogenesis remain incompletely understood. One candidate regulator is 12-lipoxygenase (12-LO), an enzyme that metabolizes arachidonic acid into the lipid mediator 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE). While 12-LO has been linked to coagulation and neutrophil interactions, its involvement in PMV production has not been clearly defined. In this study, we investigated the role of 12-LO in PMV biogenesis using both human and murine platelet models. Pharmacological inhibition of 12-LO significantly reduced 12(S)-HETE levels and PMV release in activated human platelets. Similarly, platelets from 12-LO-deficient (Alox12-/-) mice exhibited markedly impaired PMV production upon stimulation. Subpopulation analyses revealed agonist-specific effects of 12-LO deficiency on distinct PMV subsets, including mitochondrial-containing vesicles. Importantly, supplementation with exogenous 12(S)-HETE partially restored PMV production in Alox12-/- platelets, confirming the functional relevance of this lipid mediator. Together, these findings identify 12-LO as a critical regulator of PMV biogenesis and suggest that the 12-LO/12(S)-HETE axis represents a novel therapeutic target in inflammatory and thrombotic disorders.
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https://doi.org/10.1016/j.bcp.2025.117404Digital Object Identifier
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Defining the role of 12-lipoxygenase in regulating platelet-derived extracellular vesiclesWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-10-04Full publication date if available
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Alexis J Matthew, Jaël D Richard, Vanessa L. Gauvin, Mathieu P.A. Hébert, Mohamed Touaibia, Éric P. Allain, Luc H. BoudreauList of authors in order
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https://doi.org/10.1016/j.bcp.2025.117404Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.bcp.2025.117404Direct OA link when available
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| abstract_inverted_index.One | 48 |
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| abstract_inverted_index.that | 56, 183 |
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| abstract_inverted_index.These | 30 |
| abstract_inverted_index.While | 67 |
| abstract_inverted_index.human | 101, 119 |
| abstract_inverted_index.lipid | 62, 167 |
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| abstract_inverted_index.their | 5, 43 |
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| abstract_inverted_index.remain | 45 |
| abstract_inverted_index.study, | 89 |
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| abstract_inverted_index.(PMVs). | 29 |
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| abstract_inverted_index.(Alox12<sup>-</sup>/<sup>-</sup>) | 125 |
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