Delafloxacin-Loaded Poly(d ,l -lactide-co-glycolide) Nanoparticles for Topical Ocular Use: In Vitro Characterization and Antimicrobial Activity
Article Swipe
Abdullah K. Alshememry
,
Mohd Abul Kalam
,
Mudassar Shahid
,
Raisuddin Ali
,
Sulaiman S. Alhudaithi
,
Nada A. Alshumaimeri
,
Ziyad A. BinHudhud
,
Abdulrazzaq A. Aldaham
,
Ziyad Binkhathlan
,
Aliyah Almomen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.4c07805
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.4c07805
Objective: We developed delafloxacin (Dela)-loaded PLGA nanoparticles (PNPs) for potential ocular application via a topical route to treat eye infections caused by Gram-positive and Gram-negative bacteria. Methodology: Dela-PNPs were formulated using the emulsification-solvent evaporation method and stabilized using poly(vinyl alcohol) (PVA). Size and morphology were characterized by using dynamic light scattering (DLS) and scanning electron microscopy (SEM). Drug loading and encapsulation efficiency were measured via HPLC. Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) assessed the physical state and drug-polymer interaction. The in vitro drug release was evaluated using the dialysis bag method in simulated tear fluid (STF, pH 7.4) with Tween 80 (0.5%). The antimicrobial efficacy was determined by a minimum inhibitory concentration (MIC) and zone of inhibition tests against various bacteria. Results: Optimally sized PNPs were produced (238.9 ± 10.2 nm) with a PDI of 0.258 ± 0.084 and a ζ-potential of 2.78 ± 0.34 mV. Using 40 mg of PLGA, 4 mg of Dela, and 1% PVA, drug encapsulation and loading were 84.6 ± 7.3 and 12.9 ± 1.7%, respectively. DSC indicated that Dela was entrapped in an amorphous state within the PNPs. FTIR spectra showed no drug-polymer interactions. The formulation showed 40.6 ± 4.2% drug release within 24 h and 84.4 ± 6.1% by 96 h. MIC tests showed high susceptibility of Streptococcus pneumoniae, Klebsiella pneumoniae, and Escherichia coli (∼0.31 μg/mL) compared to Staphylococcus aureus and MRSA-6538 (∼0.63 μg/mL) and Bacillus subtilis (2.5 μg/mL). Stability studies showed minimal changes in particle characteristics over 3- and 6-month storage at 25 and 37 °C. Conclusion: Dela-PNPs exhibit significant potential as a nanoformulation for ocular applications.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsomega.4c07805
- OA Status
- gold
- Cited By
- 1
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405334013
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405334013Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsomega.4c07805Digital Object Identifier
- Title
-
Delafloxacin-Loaded Poly(
d ,l -lactide-co-glycolide) Nanoparticles for Topical Ocular Use: In Vitro Characterization and Antimicrobial ActivityWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-12Full publication date if available
- Authors
-
Abdullah K. Alshememry, Mohd Abul Kalam, Mudassar Shahid, Raisuddin Ali, Sulaiman S. Alhudaithi, Nada A. Alshumaimeri, Ziyad A. BinHudhud, Abdulrazzaq A. Aldaham, Ziyad Binkhathlan, Aliyah AlmomenList of authors in order
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https://doi.org/10.1021/acsomega.4c07805Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1021/acsomega.4c07805Direct OA link when available
- Concepts
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In vitro, Chemistry, Antimicrobial, Nanoparticle, Microbiology, Biochemistry, Nanotechnology, Materials science, Organic chemistry, BiologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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