Demystifying autoimmune HIT: what it is, when to test, and how to treat Article Swipe
Marie Scully
,
Will Lester
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1182/hematology.2024000565
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1182/hematology.2024000565
Antibodies to platelet factor 4 (PF4) have been primarily linked to classical heparin-induced thrombocytopenia (cHIT). However, during the rollout of the COVID-19 vaccine program a new condition, vaccine-induced thrombocytopenia and thrombosis (VITT), was identified, related to adenoviral-based COVID-19 vaccines. The differences between these 2 conditions, both clinically and in laboratory testing, set the scene for the development of a new rapid anti-PF4 assay that is not linked with heparin (as relevant for cHIT). Concurrently, there has been a reassessment of those cases described as autoimmune HIT. Such scenarios do not follow cHIT, but there is now a clearer differentiation of heparin-dependent and heparin-independent anti-PF4 conditions. The importance of this distinction is the identification of heparin-independent anti-PF4 antibodies in a new subgroup termed VITT-like disorder. Cases appear to be rare, precipitated by infection and in a proportion of cases, orthopaedic surgery, but are associated with high mortality and the need for a different treatment pathway, which includes immunomodulation therapy.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1182/hematology.2024000565
- OA Status
- green
- References
- 22
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405108462Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1182/hematology.2024000565Digital Object Identifier
- Title
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Demystifying autoimmune HIT: what it is, when to test, and how to treatWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-06Full publication date if available
- Authors
-
Marie Scully, Will LesterList of authors in order
- Landing page
-
https://doi.org/10.1182/hematology.2024000565Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/11665499Direct OA link when available
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Heparin, Platelet factor 4, Heparin-induced thrombocytopenia, Medicine, Antibody, Immunology, Thrombosis, Intensive care medicine, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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22Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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