Denatonium benzoate decreases the effect of histamine in vitro and in rats Article Swipe
Plamen Zagorchev
,
Vesela Kokova
,
Elisaveta Apostolova
,
Milena Draganova-Filipova
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4314/tjpr.v19i9.12
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4314/tjpr.v19i9.12
Purpose: To evaluate the effect of denatonium benzoate (DB) in histamine-induced model of inflammation and the effect of the selective H1 receptor agonist (2-(2-Pyridyl) ethylamine) on rat gastric smooth muscle strips pretreated with DB.Methods: The anti-inflammatory effect of DB was evaluated in vivo on histamine-induced rat paw edema. In vitro studies on spontaneous muscle contraction were performed on smooth muscle strips isolated from rat gastric corpus.Results: The results showed a well-defined anti-inflammatory effect of DB (15 mg/kg) during the early stage of rat paw edema at the 15th (p < 0.001), 30th (p < 0.01) and 60th min (p < 0.001) compared to control. In vitro experiments indicated reduced spontaneous contractile activity of smooth muscle strips to H1 receptor agonist in the presence of DB (0.5 μM). The vascular effects of histamine are mediated by H1 receptors. Substances, which reduce the effect of histamine on the H1 receptors could influence the early stage of histamine-induced inflammation.Conclusion: The results show that the anti-inflammatory activity of DB probably is related to its antagonistic activity on histamine H1 receptors. The results would contribute to the search for new antiinflammatory drugs. Keywords: Denatonium benzoate, Inflammation, Histamine, Muscle contraction
Related Topics
Concepts
Histamine
Chemistry
Agonist
Histamine H1 receptor
Endocrinology
Internal medicine
In vivo
Receptor
Contraction (grammar)
Histamine receptor
Edema
Inflammation
In vitro
Pharmacology
Medicine
Biology
Biochemistry
Antagonist
Biotechnology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4314/tjpr.v19i9.12
- https://www.ajol.info/index.php/tjpr/article/download/201768/190273
- OA Status
- gold
- Cited By
- 3
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3125815843
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3125815843Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4314/tjpr.v19i9.12Digital Object Identifier
- Title
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Denatonium benzoate decreases the effect of histamine in vitro and in ratsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-11-23Full publication date if available
- Authors
-
Plamen Zagorchev, Vesela Kokova, Elisaveta Apostolova, Milena Draganova-FilipovaList of authors in order
- Landing page
-
https://doi.org/10.4314/tjpr.v19i9.12Publisher landing page
- PDF URL
-
https://www.ajol.info/index.php/tjpr/article/download/201768/190273Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.ajol.info/index.php/tjpr/article/download/201768/190273Direct OA link when available
- Concepts
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Histamine, Chemistry, Agonist, Histamine H1 receptor, Endocrinology, Internal medicine, In vivo, Receptor, Contraction (grammar), Histamine receptor, Edema, Inflammation, In vitro, Pharmacology, Medicine, Biology, Biochemistry, Antagonist, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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21Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_date | 2020-11-23 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2982165643, https://openalex.org/W2123224090, https://openalex.org/W2020342012, https://openalex.org/W2889432911, https://openalex.org/W2032710749, https://openalex.org/W2114783676, https://openalex.org/W2898422993, https://openalex.org/W2302926024, https://openalex.org/W4238793799, https://openalex.org/W2165664061, https://openalex.org/W2959044848, https://openalex.org/W2106805920, https://openalex.org/W1554533455, https://openalex.org/W2095033598, https://openalex.org/W2887592114, https://openalex.org/W2579869862, https://openalex.org/W1978760751, https://openalex.org/W2137311570, https://openalex.org/W2123318097, https://openalex.org/W2089436185, https://openalex.org/W2745693756 |
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