Dendritic cell vaccines for high-grade gliomas Article Swipe

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Matthew E. Eagles , Farshad Nassiri , Jetan H. Badhiwala , Suganth Suppiah , Saleh A. Almenawer , Gelareh Zadeh , Kenneth Aldape ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.2147/tcrm.s135865

Glioblastoma (GBM) is the most common and fatal primary adult brain tumor. To date, various promising chemotherapeutic regimens have been trialed for use in GBM; however, temozolomide (TMZ) therapy remains the only US Food and Drug Administration-approved first-line chemotherapeutic option for newly diagnosed GBM. Despite maximal therapy with surgery and combined concurrent chemoradiation and adjuvant TMZ therapy, the median overall survival remains approximately 14 months. Given the failure of conventional chemotherapeutic strategies in GBM, there has been renewed interest in the role of immunotherapy in GBM. Dendritic cells are immune antigen-presenting cells that play a role in both the innate and adaptive immune system, thereby making them prime vehicles for immunotherapy via dendritic cell vaccinations (DCVs) in various cancers. There is great enthusiasm surrounding the use of DCVs for GBM with multiple ongoing trials. In this review, we comprehensively summarize the safety, efficacy, and quality of life results from 33 trials reporting on DCV for high-grade gliomas.

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Medicine Temozolomide Adjuvant Immunotherapy Glioma Dendritic cell Immune system Oncology Internal medicine Cancer research Immunology

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Type: review
Language: en
Landing Page: https://doi.org/10.2147/tcrm.s135865
PDF: https://www.dovepress.com/getfile.php?fileID=43329
OA Status: gold
Cited By: 53
References: 104
Related Works: 10
OpenAlex ID: https://openalex.org/W2883891816

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OpenAlex ID: https://openalex.org/W2883891816

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DOI: https://doi.org/10.2147/tcrm.s135865

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Title: Dendritic cell vaccines for high-grade gliomas

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Type: review

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Language: en

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Publication year: 2018

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Publication date: 2018-07-01

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Authors: Matthew E. Eagles, Farshad Nassiri, Jetan H. Badhiwala, Suganth Suppiah, Saleh A. Almenawer, Gelareh Zadeh, Kenneth Aldape

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Landing page: https://doi.org/10.2147/tcrm.s135865

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Concepts: Medicine, Temozolomide, Adjuvant, Immunotherapy, Glioma, Dendritic cell, Immune system, Oncology, Internal medicine, Cancer research, Immunology

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Cited by: 53

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