Deoxynivalenol triggers mitotic catastrophe and apoptosis in C2C12 myoblasts Article Swipe
Zhenzhen Wang
,
Huimin Duan
,
Xue You
,
Qian Peng
,
Ningyang Yuan
,
Rula Sha
,
Zhiqin Xie
,
Ying Feng
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ecoenv.2024.116607
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ecoenv.2024.116607
Deoxynivalenol (DON), commonly known as vomitoxin, is a mycotoxin produced by fungi and is frequently found as a contaminant in various cereal-based food worldwide. While the harmful effects of DON have been extensively studied in different tissues, its specific impact on the proliferation of skeletal muscle cells remains unclear. In this study, we utilized murine C2C12 myoblasts as a model to explore the influence of DON on their proliferation. Our observations indicated that DON exhibits dose-dependent toxicity, significantly inhibiting the proliferation of C2C12 cells. Through the application of RNA-seq analysis combined with gene set enrichment analysis, we identified a noteworthy downregulation of genes linked to the extracellular matrix (ECM) and condensed chromosome. Concurrently with the reduced expression of ECM genes, immunostaining analysis revealed notable changes in the distribution of fibronectin, a vital ECM component, condensing into clusters and punctate formations. Remarkably, the exposure to DON induced the formation of multipolar spindles, leading to the disruption of the normal cell cycle. This, in turn, activated the p53-p21 signaling pathway and ultimately resulted in apoptosis. These findings contribute significant insights into the mechanisms through which DON induces toxicity within skeletal muscle cells.
Related Topics
Concepts
C2C12
Apoptosis
Myocyte
Mitosis
Cell biology
Mitotic catastrophe
Chemistry
Biology
Myogenesis
Programmed cell death
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ecoenv.2024.116607
- OA Status
- gold
- Cited By
- 4
- References
- 41
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4399908548Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.ecoenv.2024.116607Digital Object Identifier
- Title
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Deoxynivalenol triggers mitotic catastrophe and apoptosis in C2C12 myoblastsWork title
- Type
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articleOpenAlex work type
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-21Full publication date if available
- Authors
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Zhenzhen Wang, Huimin Duan, Xue You, Qian Peng, Ningyang Yuan, Rula Sha, Zhiqin Xie, Ying FengList of authors in order
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https://doi.org/10.1016/j.ecoenv.2024.116607Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.ecoenv.2024.116607Direct OA link when available
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C2C12, Apoptosis, Myocyte, Mitosis, Cell biology, Mitotic catastrophe, Chemistry, Biology, Myogenesis, Programmed cell death, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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