Depression is both a risk factor for and outcome from traumatic brain injury in UK Biobank (N=502,356) Article Swipe
M Mäntylä
,
Emma Russell
,
Xingxing Zhu
,
Thomas McCabe
,
William Stewart
,
Donald M. Lyall
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31234/osf.io/v74ks_v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31234/osf.io/v74ks_v1
Background: Traumatic brain injury (TBI) is a known risk factor for dementia and earlier mortality, but its association with psychological health is less well-characterized. We tested for associations between TBI and depression, each ascertained multiple ways, and in opposing directions (depression predicting TBI; TBI predicting depression). Methods: Using UK Biobank data (N=502,356) we investigated bi-directional associations between TBI (ICD-10 coded broad- or narrow-band TBI) and depression (self-report and/or incident ICD-10 coded). We tested this in each direction: baseline historic TBI predicting the incidence of subsequent depression and, separately, baseline depression predicting the incidence of a first subsequent TBI. All analyses were adjusted for age at UK Biobank baseline assessment, sex, educational attainment, deprivation, smoking history, alcohol intake, physical and neurological health conditions.Results: In participants with history of TBI (versus not), there was increased risk of subsequent incident depression, compared with participants with no documented TBI history (e.g. narrow-band TBI fully-adjusted hazard ratio [HR] = 2.18 risk of depression; 95% confidence interval [CI] = 1.87 to 2.55; P<0.001). In the other direction there was evidence that people with history of lifetime depression had significantly increased risk of subsequent incident TBI (e.g. HR = 1.76 of narrow-band TBI, 95% CI = 1.61 to 1.94, P<0.001). Conclusion: We show significant associations between TBI and depression: depression was a risk factor for subsequent TBI in previously unaffected participants, but also vice-versa. Psychological support should be considered post-TBI, however clinical management should consider premorbid psychological health as a possible contributing factor.
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Metadata
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- Language
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- Landing Page
- https://doi.org/10.31234/osf.io/v74ks_v1
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W4413304927Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.31234/osf.io/v74ks_v1Digital Object Identifier
- Title
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Depression is both a risk factor for and outcome from traumatic brain injury in UK Biobank (N=502,356)Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
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2025-08-18Full publication date if available
- Authors
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M Mäntylä, Emma Russell, Xingxing Zhu, Thomas McCabe, William Stewart, Donald M. LyallList of authors in order
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https://doi.org/10.31234/osf.io/v74ks_v1Publisher landing page
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://doi.org/10.31234/osf.io/v74ks_v1Direct OA link when available
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Biobank, Traumatic brain injury, Depression (economics), Outcome (game theory), Risk factor, Medicine, Psychology, Psychiatry, Internal medicine, Bioinformatics, Biology, Economics, Mathematical economics, MacroeconomicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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