Descriptive analysis of clinical and laboratory findings in relation to changes in SARS-CoV-2 viral dynamics and cyclic threshold: a retrospective, single center observational study in patients treated with Hydroxychloroquine/Azithromycin combination therapy Article Swipe
Maha Al‐Amri
,
Edward Devol
,
Anwar B. Al-Otaibi
,
Faisal Albaiz
,
Mayyadah Alabdely
,
Sahar Althawadi
,
Maysoon S. Mutabagani
,
Fatimah S. Alhamlan
,
Fahad Alrabiah
,
Reem S. Almaghrabi
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.12688/f1000research.28290.1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.12688/f1000research.28290.1
Background: Cases of undiagnosed pneumonia have emerged, and sequencing of respiratory samples indicated the presence of SARS-CoV-2 causing COVID-19. Patients with higher viral load and lower Ct values tend to have progressive disease and severe lung injury. The objective of this study is to describe the clinical manifestation and disease outcomes of COVID-19 patients in relation to their Ct values. Methods: A retrospective, single center observational study was performed, including patients admitted to King Faisal Specialist Hospital and Research Centre (KFSH&RC) Riyadh between March 1st-29th, 2020 and have a confirmed diagnosis of COVID-19. The Ct value was identified to determine the viral load. All patients were treated according to KFSH&RC guidelines. Patients were divided into HCQ/AZI and non HCQ/AZI treated groups. Results: There were many days where Ct values were not available. An attempt at imputing information for missing Ct values was made using logic. The logic leads to an ordinal Ct score 1, 2, 3, or 4. As a result, complete Ct score profiles were available. There was no evidence of statistically significant difference between the two groups in regard to clinical severity, duration to negative test or changes in Ct values. Conclusion: There is little knowledge known to the time profile of Ct values and their relation to disease course of COVID-19. This study provides insight on how Ct values might be used to determine treatment efficacy. As it might be difficult to obtain Ct values at all times, this study provides an imputation method that may be used with conservative statistical assumptions for analyses of Ct profiles.
Related Topics
Concepts
Medicine
Disease
Coronavirus disease 2019 (COVID-19)
Azithromycin
Observational study
Internal medicine
Biology
Infectious disease (medical specialty)
Antibiotics
Microbiology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.12688/f1000research.28290.1
- https://f1000research.com/articles/11-925/pdf
- OA Status
- gold
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4290805530
All OpenAlex metadata
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https://openalex.org/W4290805530Canonical identifier for this work in OpenAlex
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https://doi.org/10.12688/f1000research.28290.1Digital Object Identifier
- Title
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Descriptive analysis of clinical and laboratory findings in relation to changes in SARS-CoV-2 viral dynamics and cyclic threshold: a retrospective, single center observational study in patients treated with Hydroxychloroquine/Azithromycin combination therapyWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-08-11Full publication date if available
- Authors
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Maha Al‐Amri, Edward Devol, Anwar B. Al-Otaibi, Faisal Albaiz, Mayyadah Alabdely, Sahar Althawadi, Maysoon S. Mutabagani, Fatimah S. Alhamlan, Fahad Alrabiah, Reem S. AlmaghrabiList of authors in order
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https://doi.org/10.12688/f1000research.28290.1Publisher landing page
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https://f1000research.com/articles/11-925/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://f1000research.com/articles/11-925/pdfDirect OA link when available
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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