Design and Implementation of a Multi‐Center Trial of 129 Xe Gas Exchange MRI and MRS to Evaluate Longitudinal Progression of COPD
Article Swipe
Bastiaan Driehuys
,
Shuo Zhang
,
Aryil Bechtel
,
Andrew D. Hahn
,
Guilhem Collier
,
Peter Niedbalski
,
Yuh-Chin T. Huang
,
Zackary I. Cleveland
,
Matthew M. Willmering
,
John P. Mugler
,
Jaime F. Mata
,
Yun M. Shim
,
Mario Castro
,
Sarah Svenningsen
,
Yonni Friedlander
,
Terence Ho
,
Sean B. Fain
,
Eric A. Hoffman
,
Jim M. Wild
,
Robert P. Thomen
,
Talissa A. Altes
,
Ummul Afia Shammi
,
William Proctor Harris
,
Yixuan Zou
,
Alexandre Fernandez Coimbra
,
Paula Belloni
,
Laura C. Bell
,
David Mummy
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/jmri.29769
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/jmri.29769
MR imaging holds the potential to enhance drug development efficiency by de‐risking early phase studies and increasing confidence in results. It can improve patient selection, increase repeatability, and provide greater sensitivity to change, thereby enabling smaller, faster clinical trials. For trials in the pulmonary space, hyperpolarized 129 Xe MRI is appealing because it provides 3‐dimensional imaging of pulmonary ventilation and gas exchange in a brief, non‐invasive exam. Metrics derived from 129 Xe MRI may be more sensitive to disease progression than conventional lung function assessments and may thus provide a valuable means to evaluate numerous novel pharmacologic and biologic therapies now in development. However, despite the acute need for better patient selection and for prognostic and monitoring biomarkers, 129 Xe MR imaging is not yet widely utilized in pulmonary drug development, partly because such trials must be conducted at multiple centers to enroll enough participants. Thus, incorporating 129 Xe MRI requires broader dissemination, harmonized image acquisition protocols, standardized dose delivery, visualization, and quantification. Multi‐site trials must also be able to operate across all major MRI vendor platforms and diverse software/hardware revisions. To this end, the 129 Xe MRI Clinical trials consortium has published a harmonized protocol describing four recommended acquisitions. Here we report on the first industry‐sponsored study to deploy this 129 Xe MRI/MRS protocol in a multi‐center, multi‐platform, multi‐national study to evaluate longitudinal progression of chronic obstructive pulmonary disease (COPD). We demonstrate the steps necessary to implement standardized 129 Xe‐MRI acquisition techniques across multiple sites and discuss the practices implemented, quality control approaches, and lessons learned for facilitating and accelerating the implementation of future trials that incorporate this technology. Level of Evidence: 5.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jmri.29769
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmri.29769
- OA Status
- bronze
- Cited By
- 2
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409697145
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409697145Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jmri.29769Digital Object Identifier
- Title
-
Design and Implementation of a Multi‐Center Trial of
129 Xe Gas ExchangeMRI andMRS to Evaluate Longitudinal Progression ofCOPD Work title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-23Full publication date if available
- Authors
-
Bastiaan Driehuys, Shuo Zhang, Aryil Bechtel, Andrew D. Hahn, Guilhem Collier, Peter Niedbalski, Yuh-Chin T. Huang, Zackary I. Cleveland, Matthew M. Willmering, John P. Mugler, Jaime F. Mata, Yun M. Shim, Mario Castro, Sarah Svenningsen, Yonni Friedlander, Terence Ho, Sean B. Fain, Eric A. Hoffman, Jim M. Wild, Robert P. Thomen, Talissa A. Altes, Ummul Afia Shammi, William Proctor Harris, Yixuan Zou, Alexandre Fernandez Coimbra, Paula Belloni, Laura C. Bell, David MummyList of authors in order
- Landing page
-
https://doi.org/10.1002/jmri.29769Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmri.29769Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmri.29769Direct OA link when available
- Concepts
-
Clinical trial, Medicine, Protocol (science), COPD, Medical physics, Pathology, Internal medicine, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4409697145 |
|---|---|
| doi | https://doi.org/10.1002/jmri.29769 |
| ids.doi | https://doi.org/10.1002/jmri.29769 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40266001 |
| ids.openalex | https://openalex.org/W4409697145 |
| fwci | 6.88456617 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000000981 |
| mesh[1].descriptor_ui | D029424 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | diagnostic imaging |
| mesh[1].descriptor_name | Pulmonary Disease, Chronic Obstructive |
| mesh[2].qualifier_ui | Q000379 |
| mesh[2].descriptor_ui | D008279 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | methods |
| mesh[2].descriptor_name | Magnetic Resonance Imaging |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D014979 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Xenon Isotopes |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D018450 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Disease Progression |
| mesh[5].qualifier_ui | Q000000981 |
| mesh[5].descriptor_ui | D008168 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | diagnostic imaging |
| mesh[5].descriptor_name | Lung |
| mesh[6].qualifier_ui | Q000379 |
| mesh[6].descriptor_ui | D009682 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | methods |
| mesh[6].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D015203 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Reproducibility of Results |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D015337 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Multicenter Studies as Topic |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D008137 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Longitudinal Studies |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D021621 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Imaging, Three-Dimensional |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008297 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Male |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | Q000000981 |
| mesh[13].descriptor_ui | D029424 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | diagnostic imaging |
| mesh[13].descriptor_name | Pulmonary Disease, Chronic Obstructive |
| mesh[14].qualifier_ui | Q000379 |
| mesh[14].descriptor_ui | D008279 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | methods |
| mesh[14].descriptor_name | Magnetic Resonance Imaging |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D014979 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Xenon Isotopes |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D018450 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Disease Progression |
| mesh[17].qualifier_ui | Q000000981 |
| mesh[17].descriptor_ui | D008168 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | diagnostic imaging |
| mesh[17].descriptor_name | Lung |
| mesh[18].qualifier_ui | Q000379 |
| mesh[18].descriptor_ui | D009682 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | methods |
| mesh[18].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D015203 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Reproducibility of Results |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D015337 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Multicenter Studies as Topic |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D008137 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Longitudinal Studies |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D021621 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Imaging, Three-Dimensional |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D008297 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Male |
| type | article |
| title | Design and Implementation of a Multi‐Center Trial of |
| awards[0].id | https://openalex.org/G7425471664 |
| awards[0].funder_id | https://openalex.org/F4320332161 |
| awards[0].display_name | |
| awards[0].funder_award_id | R01HL126771 |
| awards[0].funder_display_name | National Institutes of Health |
| awards[1].id | https://openalex.org/G4600271629 |
| awards[1].funder_id | https://openalex.org/F4320332161 |
| awards[1].display_name | |
| awards[1].funder_award_id | 1S10OD026960 |
| awards[1].funder_display_name | National Institutes of Health |
| awards[2].id | https://openalex.org/G4049319106 |
| awards[2].funder_id | https://openalex.org/F4320332161 |
| awards[2].display_name | |
| awards[2].funder_award_id | R01HL105643 |
| awards[2].funder_display_name | National Institutes of Health |
| awards[3].id | https://openalex.org/G3434259451 |
| awards[3].funder_id | https://openalex.org/F4320332161 |
| awards[3].display_name | |
| awards[3].funder_award_id | R01HL168446 |
| awards[3].funder_display_name | National Institutes of Health |
| biblio.issue | 6 |
| biblio.volume | 62 |
| biblio.last_page | 1891 |
| biblio.first_page | 1879 |
| topics[0].id | https://openalex.org/T11993 |
| topics[0].field.id | https://openalex.org/fields/31 |
| topics[0].field.display_name | Physics and Astronomy |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3107 |
| topics[0].subfield.display_name | Atomic and Molecular Physics, and Optics |
| topics[0].display_name | Atomic and Subatomic Physics Research |
| topics[1].id | https://openalex.org/T11809 |
| topics[1].field.id | https://openalex.org/fields/16 |
| topics[1].field.display_name | Chemistry |
| topics[1].score | 0.9984999895095825 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1607 |
| topics[1].subfield.display_name | Spectroscopy |
| topics[1].display_name | Advanced NMR Techniques and Applications |
| topics[2].id | https://openalex.org/T10378 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9965999722480774 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2741 |
| topics[2].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[2].display_name | Advanced MRI Techniques and Applications |
| funders[0].id | https://openalex.org/F4320306350 |
| funders[0].ror | https://ror.org/011qkaj49 |
| funders[0].display_name | Genentech Foundation |
| funders[1].id | https://openalex.org/F4320332161 |
| funders[1].ror | https://ror.org/01cwqze88 |
| funders[1].display_name | National Institutes of Health |
| is_xpac | False |
| apc_list.value | 3500 |
| apc_list.currency | USD |
| apc_list.value_usd | 3500 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C535046627 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6893426179885864 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q30612 |
| concepts[0].display_name | Clinical trial |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.5384134650230408 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2780385302 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5011444091796875 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q367158 |
| concepts[2].display_name | Protocol (science) |
| concepts[3].id | https://openalex.org/C2776780178 |
| concepts[3].level | 2 |
| concepts[3].score | 0.49205249547958374 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q199804 |
| concepts[3].display_name | COPD |
| concepts[4].id | https://openalex.org/C19527891 |
| concepts[4].level | 1 |
| concepts[4].score | 0.46580037474632263 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1120908 |
| concepts[4].display_name | Medical physics |
| concepts[5].id | https://openalex.org/C142724271 |
| concepts[5].level | 1 |
| concepts[5].score | 0.19337144494056702 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[5].display_name | Pathology |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.12083354592323303 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C204787440 |
| concepts[7].level | 2 |
| concepts[7].score | 0.0 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q188504 |
| concepts[7].display_name | Alternative medicine |
| keywords[0].id | https://openalex.org/keywords/clinical-trial |
| keywords[0].score | 0.6893426179885864 |
| keywords[0].display_name | Clinical trial |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.5384134650230408 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/protocol |
| keywords[2].score | 0.5011444091796875 |
| keywords[2].display_name | Protocol (science) |
| keywords[3].id | https://openalex.org/keywords/copd |
| keywords[3].score | 0.49205249547958374 |
| keywords[3].display_name | COPD |
| keywords[4].id | https://openalex.org/keywords/medical-physics |
| keywords[4].score | 0.46580037474632263 |
| keywords[4].display_name | Medical physics |
| keywords[5].id | https://openalex.org/keywords/pathology |
| keywords[5].score | 0.19337144494056702 |
| keywords[5].display_name | Pathology |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.12083354592323303 |
| keywords[6].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.1002/jmri.29769 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S132538424 |
| locations[0].source.issn | 1053-1807, 1522-2586 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1053-1807 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Magnetic Resonance Imaging |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmri.29769 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Magnetic Resonance Imaging |
| locations[0].landing_page_url | https://doi.org/10.1002/jmri.29769 |
| locations[1].id | pmid:40266001 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of magnetic resonance imaging : JMRI |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40266001 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5049663049 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1236-4210 |
| authorships[0].author.display_name | Bastiaan Driehuys |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210126298 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| authorships[0].institutions[0].id | https://openalex.org/I4210126298 |
| authorships[0].institutions[0].ror | https://ror.org/03njmea73 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210126298, https://openalex.org/I4210144876 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Duke Medical Center |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Bastiaan Driehuys |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| authorships[1].author.id | https://openalex.org/A5100450363 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-2284-7427 |
| authorships[1].author.display_name | Shuo Zhang |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210126298 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| authorships[1].institutions[0].id | https://openalex.org/I4210126298 |
| authorships[1].institutions[0].ror | https://ror.org/03njmea73 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210126298, https://openalex.org/I4210144876 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Duke Medical Center |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Shuo Zhang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| authorships[2].author.id | https://openalex.org/A5022316777 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2928-3898 |
| authorships[2].author.display_name | Aryil Bechtel |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210126298 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| authorships[2].institutions[0].id | https://openalex.org/I4210126298 |
| authorships[2].institutions[0].ror | https://ror.org/03njmea73 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210126298, https://openalex.org/I4210144876 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Duke Medical Center |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Aryil Bechtel |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| authorships[3].author.id | https://openalex.org/A5018983084 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0246-2108 |
| authorships[3].author.display_name | Andrew D. Hahn |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I126307644 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Radiology University of Iowa Iowa City Iowa USA |
| authorships[3].institutions[0].id | https://openalex.org/I126307644 |
| authorships[3].institutions[0].ror | https://ror.org/036jqmy94 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I126307644 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Iowa |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Andrew D. Hahn |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Radiology University of Iowa Iowa City Iowa USA |
| authorships[4].author.id | https://openalex.org/A5036048022 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1874-4775 |
| authorships[4].author.display_name | Guilhem Collier |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I91136226 |
| authorships[4].affiliations[0].raw_affiliation_string | POLARIS, Division of Clinical Medicine School of Medicine and Population Health, University of Sheffield Sheffield UK |
| authorships[4].institutions[0].id | https://openalex.org/I91136226 |
| authorships[4].institutions[0].ror | https://ror.org/05krs5044 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I91136226 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | University of Sheffield |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Guilhem Collier |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | POLARIS, Division of Clinical Medicine School of Medicine and Population Health, University of Sheffield Sheffield UK |
| authorships[5].author.id | https://openalex.org/A5011841978 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0528-2508 |
| authorships[5].author.display_name | Peter Niedbalski |
| authorships[5].countries | US |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Pulmonary, Critical Care, and Sleep of Kansas Medical Center Kansas City Kansas USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I4210128618, https://openalex.org/I4210166946 |
| authorships[5].affiliations[1].raw_affiliation_string | Hoglund Biomedical Imaging Center University of Kansas Medical Center Kansas City Kansas USA |
| authorships[5].institutions[0].id | https://openalex.org/I4210166946 |
| authorships[5].institutions[0].ror | https://ror.org/05hsqsk33 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210166946 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Imaging Center |
| authorships[5].institutions[1].id | https://openalex.org/I4210128618 |
| authorships[5].institutions[1].ror | https://ror.org/036c9yv20 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210128618 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | University of Kansas Medical Center |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Peter J. Niedbalski |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Pulmonary, Critical Care, and Sleep of Kansas Medical Center Kansas City Kansas USA, Hoglund Biomedical Imaging Center University of Kansas Medical Center Kansas City Kansas USA |
| authorships[6].author.id | https://openalex.org/A5109650111 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Yuh-Chin T. Huang |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Medicine Duke University Durham North Carolina USA |
| authorships[6].institutions[0].id | https://openalex.org/I170897317 |
| authorships[6].institutions[0].ror | https://ror.org/00py81415 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Duke University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yuh‐Chin Huang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Medicine Duke University Durham North Carolina USA |
| authorships[7].author.id | https://openalex.org/A5020592001 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-6195-9061 |
| authorships[7].author.display_name | Zackary I. Cleveland |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1285204247 |
| authorships[7].affiliations[0].raw_affiliation_string | Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I92156820 |
| authorships[7].affiliations[1].raw_affiliation_string | Department of Pediatrics College of Medicine, University of Cincinnati Cincinnati Ohio USA |
| authorships[7].institutions[0].id | https://openalex.org/I1285204247 |
| authorships[7].institutions[0].ror | https://ror.org/01hcyya48 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1285204247 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Cincinnati Children's Hospital Medical Center |
| authorships[7].institutions[1].id | https://openalex.org/I92156820 |
| authorships[7].institutions[1].ror | https://ror.org/02p72h367 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I92156820 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | University of Cincinnati Medical Center |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Zackary I. Cleveland |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA, Department of Pediatrics College of Medicine, University of Cincinnati Cincinnati Ohio USA |
| authorships[8].author.id | https://openalex.org/A5058015755 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-4356-9622 |
| authorships[8].author.display_name | Matthew M. Willmering |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I92156820 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Pediatrics College of Medicine, University of Cincinnati Cincinnati Ohio USA |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I1285204247 |
| authorships[8].affiliations[1].raw_affiliation_string | Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA |
| authorships[8].institutions[0].id | https://openalex.org/I1285204247 |
| authorships[8].institutions[0].ror | https://ror.org/01hcyya48 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I1285204247 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Cincinnati Children's Hospital Medical Center |
| authorships[8].institutions[1].id | https://openalex.org/I92156820 |
| authorships[8].institutions[1].ror | https://ror.org/02p72h367 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I92156820 |
| authorships[8].institutions[1].country_code | US |
| authorships[8].institutions[1].display_name | University of Cincinnati Medical Center |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Matthew M. Willmering |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA, Department of Pediatrics College of Medicine, University of Cincinnati Cincinnati Ohio USA |
| authorships[9].author.id | https://openalex.org/A5026508249 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4140-308X |
| authorships[9].author.display_name | John P. Mugler |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I51556381 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Radiology & Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA |
| authorships[9].institutions[0].id | https://openalex.org/I51556381 |
| authorships[9].institutions[0].ror | https://ror.org/0153tk833 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I51556381 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of Virginia |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | John P. Mugler |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Radiology & Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA |
| authorships[10].author.id | https://openalex.org/A5019251773 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-2274-1470 |
| authorships[10].author.display_name | Jaime F. Mata |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I51556381 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Radiology & Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA |
| authorships[10].institutions[0].id | https://openalex.org/I51556381 |
| authorships[10].institutions[0].ror | https://ror.org/0153tk833 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I51556381 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University of Virginia |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Jaime Mata |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Radiology & Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA |
| authorships[11].author.id | https://openalex.org/A5038466443 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-3780-3371 |
| authorships[11].author.display_name | Yun M. Shim |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I51556381 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Radiology & Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA |
| authorships[11].institutions[0].id | https://openalex.org/I51556381 |
| authorships[11].institutions[0].ror | https://ror.org/0153tk833 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I51556381 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | University of Virginia |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Yun Michael Shim |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Radiology & Medical Imaging University of Virginia School of Medicine Charlottesville Virginia USA |
| authorships[12].author.id | https://openalex.org/A5029849168 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-6328-8994 |
| authorships[12].author.display_name | Mario Castro |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Pulmonary, Critical Care, and Sleep of Kansas Medical Center Kansas City Kansas USA |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Mario Castro |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Pulmonary, Critical Care, and Sleep of Kansas Medical Center Kansas City Kansas USA |
| authorships[13].author.id | https://openalex.org/A5062417502 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-6225-1863 |
| authorships[13].author.display_name | Sarah Svenningsen |
| authorships[13].countries | CA |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I59293822 |
| authorships[13].affiliations[0].raw_affiliation_string | Imaging Research Center St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I98251732 |
| authorships[13].affiliations[1].raw_affiliation_string | Department of Medicine McMaster University Hamilton Canada |
| authorships[13].affiliations[2].institution_ids | https://openalex.org/I59293822 |
| authorships[13].affiliations[2].raw_affiliation_string | Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[13].institutions[0].id | https://openalex.org/I98251732 |
| authorships[13].institutions[0].ror | https://ror.org/02fa3aq29 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I98251732 |
| authorships[13].institutions[0].country_code | CA |
| authorships[13].institutions[0].display_name | McMaster University |
| authorships[13].institutions[1].id | https://openalex.org/I59293822 |
| authorships[13].institutions[1].ror | https://ror.org/009z39p97 |
| authorships[13].institutions[1].type | healthcare |
| authorships[13].institutions[1].lineage | https://openalex.org/I59293822 |
| authorships[13].institutions[1].country_code | CA |
| authorships[13].institutions[1].display_name | St. Joseph’s Healthcare Hamilton |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Sarah Svenningsen |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Medicine McMaster University Hamilton Canada, Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton Hamilton Canada, Imaging Research Center St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[14].author.id | https://openalex.org/A5046899167 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-9399-7863 |
| authorships[14].author.display_name | Yonni Friedlander |
| authorships[14].countries | CA |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I59293822 |
| authorships[14].affiliations[0].raw_affiliation_string | Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I59293822 |
| authorships[14].affiliations[1].raw_affiliation_string | Imaging Research Center St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I98251732 |
| authorships[14].affiliations[2].raw_affiliation_string | Department of Medicine McMaster University Hamilton Canada |
| authorships[14].institutions[0].id | https://openalex.org/I98251732 |
| authorships[14].institutions[0].ror | https://ror.org/02fa3aq29 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I98251732 |
| authorships[14].institutions[0].country_code | CA |
| authorships[14].institutions[0].display_name | McMaster University |
| authorships[14].institutions[1].id | https://openalex.org/I59293822 |
| authorships[14].institutions[1].ror | https://ror.org/009z39p97 |
| authorships[14].institutions[1].type | healthcare |
| authorships[14].institutions[1].lineage | https://openalex.org/I59293822 |
| authorships[14].institutions[1].country_code | CA |
| authorships[14].institutions[1].display_name | St. Joseph’s Healthcare Hamilton |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Yonni Friedlander |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Medicine McMaster University Hamilton Canada, Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton Hamilton Canada, Imaging Research Center St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[15].author.id | https://openalex.org/A5011456144 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-0412-6538 |
| authorships[15].author.display_name | Terence Ho |
| authorships[15].countries | CA |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I98251732 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Medicine McMaster University Hamilton Canada |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I59293822 |
| authorships[15].affiliations[1].raw_affiliation_string | Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[15].institutions[0].id | https://openalex.org/I98251732 |
| authorships[15].institutions[0].ror | https://ror.org/02fa3aq29 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I98251732 |
| authorships[15].institutions[0].country_code | CA |
| authorships[15].institutions[0].display_name | McMaster University |
| authorships[15].institutions[1].id | https://openalex.org/I59293822 |
| authorships[15].institutions[1].ror | https://ror.org/009z39p97 |
| authorships[15].institutions[1].type | healthcare |
| authorships[15].institutions[1].lineage | https://openalex.org/I59293822 |
| authorships[15].institutions[1].country_code | CA |
| authorships[15].institutions[1].display_name | St. Joseph’s Healthcare Hamilton |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Terence Ho |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Medicine McMaster University Hamilton Canada, Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton Hamilton Canada |
| authorships[16].author.id | https://openalex.org/A5019529832 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-5461-0646 |
| authorships[16].author.display_name | Sean B. Fain |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I126307644 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Radiology University of Iowa Iowa City Iowa USA |
| authorships[16].institutions[0].id | https://openalex.org/I126307644 |
| authorships[16].institutions[0].ror | https://ror.org/036jqmy94 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I126307644 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | University of Iowa |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Sean Fain |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Radiology University of Iowa Iowa City Iowa USA |
| authorships[17].author.id | https://openalex.org/A5011527598 |
| authorships[17].author.orcid | https://orcid.org/0000-0001-8456-9437 |
| authorships[17].author.display_name | Eric A. Hoffman |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I126307644 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Radiology University of Iowa Iowa City Iowa USA |
| authorships[17].institutions[0].id | https://openalex.org/I126307644 |
| authorships[17].institutions[0].ror | https://ror.org/036jqmy94 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I126307644 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | University of Iowa |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Eric A. Hoffman |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Radiology University of Iowa Iowa City Iowa USA |
| authorships[18].author.id | https://openalex.org/A5000094254 |
| authorships[18].author.orcid | https://orcid.org/0000-0002-7246-8660 |
| authorships[18].author.display_name | Jim M. Wild |
| authorships[18].countries | GB |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I91136226 |
| authorships[18].affiliations[0].raw_affiliation_string | POLARIS, Division of Clinical Medicine School of Medicine and Population Health, University of Sheffield Sheffield UK |
| authorships[18].institutions[0].id | https://openalex.org/I91136226 |
| authorships[18].institutions[0].ror | https://ror.org/05krs5044 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I91136226 |
| authorships[18].institutions[0].country_code | GB |
| authorships[18].institutions[0].display_name | University of Sheffield |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Jim M. Wild |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | POLARIS, Division of Clinical Medicine School of Medicine and Population Health, University of Sheffield Sheffield UK |
| authorships[19].author.id | https://openalex.org/A5047161852 |
| authorships[19].author.orcid | |
| authorships[19].author.display_name | Robert P. Thomen |
| authorships[19].countries | US |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I76835614 |
| authorships[19].affiliations[0].raw_affiliation_string | Department of Radiology University of Missouri Columbia Missouri USA |
| authorships[19].institutions[0].id | https://openalex.org/I76835614 |
| authorships[19].institutions[0].ror | https://ror.org/02ymw8z06 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I76835614 |
| authorships[19].institutions[0].country_code | US |
| authorships[19].institutions[0].display_name | University of Missouri |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Robert P. Thomen |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Department of Radiology University of Missouri Columbia Missouri USA |
| authorships[20].author.id | https://openalex.org/A5015008578 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-8969-8673 |
| authorships[20].author.display_name | Talissa A. Altes |
| authorships[20].countries | US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I76835614 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Radiology University of Missouri Columbia Missouri USA |
| authorships[20].institutions[0].id | https://openalex.org/I76835614 |
| authorships[20].institutions[0].ror | https://ror.org/02ymw8z06 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I76835614 |
| authorships[20].institutions[0].country_code | US |
| authorships[20].institutions[0].display_name | University of Missouri |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Talissa Altes |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Radiology University of Missouri Columbia Missouri USA |
| authorships[21].author.id | https://openalex.org/A5061651204 |
| authorships[21].author.orcid | https://orcid.org/0000-0003-0227-1405 |
| authorships[21].author.display_name | Ummul Afia Shammi |
| authorships[21].countries | US |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I39422238 |
| authorships[21].affiliations[0].raw_affiliation_string | Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago Chicago Illinois USA |
| authorships[21].institutions[0].id | https://openalex.org/I39422238 |
| authorships[21].institutions[0].ror | https://ror.org/02mpq6x41 |
| authorships[21].institutions[0].type | education |
| authorships[21].institutions[0].lineage | https://openalex.org/I39422238 |
| authorships[21].institutions[0].country_code | US |
| authorships[21].institutions[0].display_name | University of Illinois Chicago |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Ummul Afia Shammi |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago Chicago Illinois USA |
| authorships[22].author.id | https://openalex.org/A5113286006 |
| authorships[22].author.orcid | |
| authorships[22].author.display_name | William Proctor Harris |
| authorships[22].affiliations[0].raw_affiliation_string | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Will Harris |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[23].author.id | https://openalex.org/A5063748977 |
| authorships[23].author.orcid | https://orcid.org/0000-0002-5002-2131 |
| authorships[23].author.display_name | Yixuan Zou |
| authorships[23].affiliations[0].raw_affiliation_string | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Yixuan Zou |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[24].author.id | https://openalex.org/A5015807980 |
| authorships[24].author.orcid | |
| authorships[24].author.display_name | Alexandre Fernandez Coimbra |
| authorships[24].affiliations[0].raw_affiliation_string | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Alexandre Fernandez Coimbra |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[25].author.id | https://openalex.org/A5076786308 |
| authorships[25].author.orcid | |
| authorships[25].author.display_name | Paula Belloni |
| authorships[25].affiliations[0].raw_affiliation_string | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[25].author_position | middle |
| authorships[25].raw_author_name | Paula Belloni |
| authorships[25].is_corresponding | False |
| authorships[25].raw_affiliation_strings | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[26].author.id | https://openalex.org/A5079286419 |
| authorships[26].author.orcid | https://orcid.org/0000-0001-8164-8324 |
| authorships[26].author.display_name | Laura C. Bell |
| authorships[26].affiliations[0].raw_affiliation_string | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[26].author_position | middle |
| authorships[26].raw_author_name | Laura C. Bell |
| authorships[26].is_corresponding | False |
| authorships[26].raw_affiliation_strings | Genentech Inc., OMNI Early Clinical Development South San Francisco California USA |
| authorships[27].author.id | https://openalex.org/A5020805619 |
| authorships[27].author.orcid | https://orcid.org/0000-0001-7885-109X |
| authorships[27].author.display_name | David Mummy |
| authorships[27].countries | US |
| authorships[27].affiliations[0].institution_ids | https://openalex.org/I4210126298 |
| authorships[27].affiliations[0].raw_affiliation_string | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| authorships[27].institutions[0].id | https://openalex.org/I4210126298 |
| authorships[27].institutions[0].ror | https://ror.org/03njmea73 |
| authorships[27].institutions[0].type | healthcare |
| authorships[27].institutions[0].lineage | https://openalex.org/I4210126298, https://openalex.org/I4210144876 |
| authorships[27].institutions[0].country_code | US |
| authorships[27].institutions[0].display_name | Duke Medical Center |
| authorships[27].author_position | last |
| authorships[27].raw_author_name | David Mummy |
| authorships[27].is_corresponding | False |
| authorships[27].raw_affiliation_strings | Department of Radiology Duke University Medical Center Durham North Carolina USA |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmri.29769 |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-04-24T00:00:00 |
| display_name | Design and Implementation of a Multi‐Center Trial of |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-12T23:11:45.498971 |
| primary_topic.id | https://openalex.org/T11993 |
| primary_topic.field.id | https://openalex.org/fields/31 |
| primary_topic.field.display_name | Physics and Astronomy |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3107 |
| primary_topic.subfield.display_name | Atomic and Molecular Physics, and Optics |
| primary_topic.display_name | Atomic and Subatomic Physics Research |
| related_works | https://openalex.org/W2899084033, https://openalex.org/W2748952813, https://openalex.org/W3031052312, https://openalex.org/W4389568370, https://openalex.org/W3032375762, https://openalex.org/W1995515455, https://openalex.org/W2080531066, https://openalex.org/W3108674512, https://openalex.org/W1506200166, https://openalex.org/W1489783725 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1002/jmri.29769 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S132538424 |
| best_oa_location.source.issn | 1053-1807, 1522-2586 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1053-1807 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Magnetic Resonance Imaging |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_lineage_names | Wiley |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmri.29769 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Magnetic Resonance Imaging |
| best_oa_location.landing_page_url | https://doi.org/10.1002/jmri.29769 |
| primary_location.id | doi:10.1002/jmri.29769 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S132538424 |
| primary_location.source.issn | 1053-1807, 1522-2586 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1053-1807 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Magnetic Resonance Imaging |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmri.29769 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Magnetic Resonance Imaging |
| primary_location.landing_page_url | https://doi.org/10.1002/jmri.29769 |
| publication_date | 2025-04-23 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4281638746, https://openalex.org/W3173493468, https://openalex.org/W4385620589, https://openalex.org/W7052409211, https://openalex.org/W1849412223, https://openalex.org/W2980924386, https://openalex.org/W3185549342, https://openalex.org/W2752942070, https://openalex.org/W6902847202, https://openalex.org/W4391655713, https://openalex.org/W4282917323, https://openalex.org/W4283650392, https://openalex.org/W3097101884, https://openalex.org/W2971042947, https://openalex.org/W3157062036, https://openalex.org/W4382721542, https://openalex.org/W6854084816, https://openalex.org/W1599431266, https://openalex.org/W2998932916, https://openalex.org/W3025623760, https://openalex.org/W2923942876, https://openalex.org/W3197317142, https://openalex.org/W7042749652, https://openalex.org/W2059587208, https://openalex.org/W4361222963, https://openalex.org/W2884742303, https://openalex.org/W2808604517, https://openalex.org/W2901463380, https://openalex.org/W2265275674, https://openalex.org/W4401574771, https://openalex.org/W2076760127, https://openalex.org/W2520034886, https://openalex.org/W2604112991, https://openalex.org/W4396501031, https://openalex.org/W4404747280, https://openalex.org/W3136914581, https://openalex.org/W4308954804, https://openalex.org/W4394573612, https://openalex.org/W4396805935, https://openalex.org/W3207395418, https://openalex.org/W2896042736, https://openalex.org/W3135011014, https://openalex.org/W3109137990, https://openalex.org/W7028014722, https://openalex.org/W3040407639 |
| referenced_works_count | 45 |
| abstract_inverted_index.a | 64, 90, 194, 217 |
| abstract_inverted_index.5. | 274 |
| abstract_inverted_index.It | 21 |
| abstract_inverted_index.MR | 1, 121 |
| abstract_inverted_index.To | 182 |
| abstract_inverted_index.We | 232 |
| abstract_inverted_index.Xe | 48, 72, 120, 149, 187, 213 |
| abstract_inverted_index.at | 139 |
| abstract_inverted_index.be | 75, 137, 168 |
| abstract_inverted_index.by | 11 |
| abstract_inverted_index.in | 19, 42, 63, 102, 128, 216 |
| abstract_inverted_index.is | 50, 123 |
| abstract_inverted_index.it | 53 |
| abstract_inverted_index.of | 57, 226, 264, 272 |
| abstract_inverted_index.on | 204 |
| abstract_inverted_index.to | 6, 32, 78, 93, 142, 170, 209, 222, 237 |
| abstract_inverted_index.we | 202 |
| abstract_inverted_index.129 | 47, 71, 119, 148, 186, 212, 240 |
| abstract_inverted_index.For | 40 |
| abstract_inverted_index.MRI | 49, 73, 150, 175, 188 |
| abstract_inverted_index.all | 173 |
| abstract_inverted_index.and | 16, 28, 60, 86, 98, 113, 116, 162, 178, 247, 255, 260 |
| abstract_inverted_index.can | 22 |
| abstract_inverted_index.for | 109, 114, 258 |
| abstract_inverted_index.gas | 61 |
| abstract_inverted_index.has | 192 |
| abstract_inverted_index.may | 74, 87 |
| abstract_inverted_index.not | 124 |
| abstract_inverted_index.now | 101 |
| abstract_inverted_index.the | 4, 43, 106, 185, 205, 234, 249, 262 |
| abstract_inverted_index.yet | 125 |
| abstract_inverted_index.Here | 201 |
| abstract_inverted_index.able | 169 |
| abstract_inverted_index.also | 167 |
| abstract_inverted_index.dose | 159 |
| abstract_inverted_index.drug | 8, 130 |
| abstract_inverted_index.end, | 184 |
| abstract_inverted_index.four | 198 |
| abstract_inverted_index.from | 70 |
| abstract_inverted_index.lung | 83 |
| abstract_inverted_index.more | 76 |
| abstract_inverted_index.must | 136, 166 |
| abstract_inverted_index.need | 108 |
| abstract_inverted_index.such | 134 |
| abstract_inverted_index.than | 81 |
| abstract_inverted_index.that | 267 |
| abstract_inverted_index.this | 183, 211, 269 |
| abstract_inverted_index.thus | 88 |
| abstract_inverted_index.Level | 271 |
| abstract_inverted_index.Thus, | 146 |
| abstract_inverted_index.acute | 107 |
| abstract_inverted_index.early | 13 |
| abstract_inverted_index.exam. | 67 |
| abstract_inverted_index.first | 206 |
| abstract_inverted_index.holds | 3 |
| abstract_inverted_index.image | 155 |
| abstract_inverted_index.major | 174 |
| abstract_inverted_index.means | 92 |
| abstract_inverted_index.novel | 96 |
| abstract_inverted_index.phase | 14 |
| abstract_inverted_index.sites | 246 |
| abstract_inverted_index.steps | 235 |
| abstract_inverted_index.study | 208, 221 |
| abstract_inverted_index.across | 172, 244 |
| abstract_inverted_index.better | 110 |
| abstract_inverted_index.brief, | 65 |
| abstract_inverted_index.deploy | 210 |
| abstract_inverted_index.enough | 144 |
| abstract_inverted_index.enroll | 143 |
| abstract_inverted_index.faster | 37 |
| abstract_inverted_index.future | 265 |
| abstract_inverted_index.partly | 132 |
| abstract_inverted_index.report | 203 |
| abstract_inverted_index.space, | 45 |
| abstract_inverted_index.trials | 41, 135, 165, 190, 266 |
| abstract_inverted_index.vendor | 176 |
| abstract_inverted_index.widely | 126 |
| abstract_inverted_index.(COPD). | 231 |
| abstract_inverted_index.MRI/MRS | 214 |
| abstract_inverted_index.Metrics | 68 |
| abstract_inverted_index.because | 52, 133 |
| abstract_inverted_index.broader | 152 |
| abstract_inverted_index.centers | 141 |
| abstract_inverted_index.change, | 33 |
| abstract_inverted_index.chronic | 227 |
| abstract_inverted_index.control | 253 |
| abstract_inverted_index.derived | 69 |
| abstract_inverted_index.despite | 105 |
| abstract_inverted_index.discuss | 248 |
| abstract_inverted_index.disease | 79, 230 |
| abstract_inverted_index.diverse | 179 |
| abstract_inverted_index.enhance | 7 |
| abstract_inverted_index.greater | 30 |
| abstract_inverted_index.imaging | 2, 56, 122 |
| abstract_inverted_index.improve | 23 |
| abstract_inverted_index.learned | 257 |
| abstract_inverted_index.lessons | 256 |
| abstract_inverted_index.operate | 171 |
| abstract_inverted_index.patient | 24, 111 |
| abstract_inverted_index.provide | 29, 89 |
| abstract_inverted_index.quality | 252 |
| abstract_inverted_index.studies | 15 |
| abstract_inverted_index.thereby | 34 |
| abstract_inverted_index.trials. | 39 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Clinical | 189 |
| abstract_inverted_index.However, | 104 |
| abstract_inverted_index.Xe‐MRI | 241 |
| abstract_inverted_index.biologic | 99 |
| abstract_inverted_index.clinical | 38 |
| abstract_inverted_index.enabling | 35 |
| abstract_inverted_index.evaluate | 94, 223 |
| abstract_inverted_index.exchange | 62 |
| abstract_inverted_index.function | 84 |
| abstract_inverted_index.increase | 26 |
| abstract_inverted_index.multiple | 140, 245 |
| abstract_inverted_index.numerous | 95 |
| abstract_inverted_index.protocol | 196, 215 |
| abstract_inverted_index.provides | 54 |
| abstract_inverted_index.requires | 151 |
| abstract_inverted_index.results. | 20 |
| abstract_inverted_index.smaller, | 36 |
| abstract_inverted_index.utilized | 127 |
| abstract_inverted_index.valuable | 91 |
| abstract_inverted_index.Evidence: | 273 |
| abstract_inverted_index.appealing | 51 |
| abstract_inverted_index.conducted | 138 |
| abstract_inverted_index.delivery, | 160 |
| abstract_inverted_index.implement | 238 |
| abstract_inverted_index.necessary | 236 |
| abstract_inverted_index.platforms | 177 |
| abstract_inverted_index.potential | 5 |
| abstract_inverted_index.practices | 250 |
| abstract_inverted_index.published | 193 |
| abstract_inverted_index.pulmonary | 44, 58, 129, 229 |
| abstract_inverted_index.selection | 112 |
| abstract_inverted_index.sensitive | 77 |
| abstract_inverted_index.therapies | 100 |
| abstract_inverted_index.confidence | 18 |
| abstract_inverted_index.consortium | 191 |
| abstract_inverted_index.describing | 197 |
| abstract_inverted_index.efficiency | 10 |
| abstract_inverted_index.harmonized | 154, 195 |
| abstract_inverted_index.increasing | 17 |
| abstract_inverted_index.monitoring | 117 |
| abstract_inverted_index.prognostic | 115 |
| abstract_inverted_index.protocols, | 157 |
| abstract_inverted_index.revisions. | 181 |
| abstract_inverted_index.selection, | 25 |
| abstract_inverted_index.techniques | 243 |
| abstract_inverted_index.acquisition | 156, 242 |
| abstract_inverted_index.approaches, | 254 |
| abstract_inverted_index.assessments | 85 |
| abstract_inverted_index.biomarkers, | 118 |
| abstract_inverted_index.demonstrate | 233 |
| abstract_inverted_index.development | 9 |
| abstract_inverted_index.incorporate | 268 |
| abstract_inverted_index.obstructive | 228 |
| abstract_inverted_index.progression | 80, 225 |
| abstract_inverted_index.recommended | 199 |
| abstract_inverted_index.sensitivity | 31 |
| abstract_inverted_index.technology. | 270 |
| abstract_inverted_index.ventilation | 59 |
| abstract_inverted_index.Multi‐site | 164 |
| abstract_inverted_index.accelerating | 261 |
| abstract_inverted_index.conventional | 82 |
| abstract_inverted_index.development, | 131 |
| abstract_inverted_index.development. | 103 |
| abstract_inverted_index.de‐risking | 12 |
| abstract_inverted_index.facilitating | 259 |
| abstract_inverted_index.implemented, | 251 |
| abstract_inverted_index.longitudinal | 224 |
| abstract_inverted_index.standardized | 158, 239 |
| abstract_inverted_index.acquisitions. | 200 |
| abstract_inverted_index.incorporating | 147 |
| abstract_inverted_index.participants. | 145 |
| abstract_inverted_index.pharmacologic | 97 |
| abstract_inverted_index.dissemination, | 153 |
| abstract_inverted_index.hyperpolarized | 46 |
| abstract_inverted_index.implementation | 263 |
| abstract_inverted_index.non‐invasive | 66 |
| abstract_inverted_index.repeatability, | 27 |
| abstract_inverted_index.visualization, | 161 |
| abstract_inverted_index.3‐dimensional | 55 |
| abstract_inverted_index.multi‐center, | 218 |
| abstract_inverted_index.quantification. | 163 |
| abstract_inverted_index.multi‐national | 220 |
| abstract_inverted_index.multi‐platform, | 219 |
| abstract_inverted_index.software/hardware | 180 |
| abstract_inverted_index.industry‐sponsored | 207 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 28 |
| citation_normalized_percentile.value | 0.92716539 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |