Design and Validation of a Short Novel Estradiol Aptamer and Exploration of Its Application in Sensor Technology Article Swipe
Hongyan Jin
,
Cheng Yan
,
Fanli Kong
,
He Huang
,
Zhenjun Yang
,
Xinyi Wang
,
Xinxia Cai
,
Jinping Luo
,
Tao Ming
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/molecules29020535
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/molecules29020535
The specific and sensitive detection of 17β-estradiol (E2) is critical for diagnosing and treating numerous diseases, and aptamers have emerged as promising recognition probes for developing detection platforms. However, traditional long-sequence E2 aptamers have demonstrated limited clinical performance due to redundant structures that can affect their stability and recognition ability. There is thus an urgent need to further optimize the structure of the aptamer to build an effective detection platform for E2. In this work, we have designed a novel short aptamer that retains the key binding structure of traditional aptamers to E2 while eliminating the redundant structures. The proposed aptamer was evaluated for its binding properties using microscale thermophoresis, a gold nanoparticle-based colorimetric method, and electrochemical assays. Our results demonstrate that the proposed aptamer has excellent specific recognition ability for E2 and a high affinity with a dissociation constant of 92 nM. Moreover, the aptamer shows great potential as a recognition probe for constructing a highly specific and sensitive clinical estradiol detection platform. The aptamer-based electrochemical sensor enabled the detection of E2 with a linear range between 5 pg mL–1 and 10 ng mL–1 (R2 = 0.973), and the detection capability of a definite low concentration level was 5 pg mL–1 (S/N = 3). Overall, this novel aptamer holds great promise as a valuable tool for future studies on the role of E2 in various physiological and pathological processes and for developing sensitive and specific diagnostic assays for E2 detection in clinical applications.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules29020535
- https://www.mdpi.com/1420-3049/29/2/535/pdf?version=1705912375
- OA Status
- gold
- Cited By
- 5
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391089676
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391089676Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules29020535Digital Object Identifier
- Title
-
Design and Validation of a Short Novel Estradiol Aptamer and Exploration of Its Application in Sensor TechnologyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-22Full publication date if available
- Authors
-
Hongyan Jin, Cheng Yan, Fanli Kong, He Huang, Zhenjun Yang, Xinyi Wang, Xinxia Cai, Jinping Luo, Tao MingList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules29020535Publisher landing page
- PDF URL
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https://www.mdpi.com/1420-3049/29/2/535/pdf?version=1705912375Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/29/2/535/pdf?version=1705912375Direct OA link when available
- Concepts
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Aptamer, Microscale thermophoresis, Biosensor, Computer science, Nanotechnology, Molecular recognition, Microscale chemistry, Computational biology, Chemistry, Materials science, Biology, Molecular biology, Molecule, Mathematics, Biochemistry, Organic chemistry, Mathematics educationTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
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2025: 4, 2024: 1Per-year citation counts (last 5 years)
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37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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