Design of Experiment Guided Establishment of a Fermentative Bioprocess for Biomass-Bound Astaxanthin with <em>Corynebacterium glutamicum</em> Article Swipe
Florian Meyer
,
Ina Schmitt
,
Thomas Schäffer
,
Volker F. Wendisch
,
Nadja A. Henke
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202310.0987.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202310.0987.v1
Corynebacterium glutamicum is prominent for the industrial production of secreted amino acids. Notably, it naturally accumulates the carotenoid pigment decaprenoxanthin in its membranes. Metabolic engineering enabled production of astaxanthin. Here, a bioprocess for astaxanthin production in lab-scale stirred bioreactors was established by a DoE-guided approach to optimize the basic process parameters pH, rDOS, aeration rate as well as inoculation cell density. The DoE-guided approach from 2 L scale cultivation revealed that the pH showed the strongest effect on the product formation. Subsequently, an optimum at pH 8, an aeration rate of 0.25 vvm, 30 % rDOS and an initial optical density of 1 was established that allowed production of 7.6±0.6mg L-1 astaxanthin in batch mode. These process conditions were successfully transferred to a fed-batch process resulting in a high cell density cultivation with up to 60 g CDW L-1 biomass and 64 mg L-1 astaxanthin and thus demonstrating an about 9-fold improvement compared to optimal batch conditions. Moreover, pH shifts experiments indicate that the cells can quickly adapt to a change from pH 6 to 8 and start producing astaxanthin showing the possibility of a biphasic bioprocesses for astaxanthin production.
Related Topics
Concepts
Astaxanthin
Corynebacterium glutamicum
Bioprocess
Aeration
Bioprocess engineering
Bioreactor
Chemistry
Biomass (ecology)
Batch processing
Continuous stirred-tank reactor
Food science
Carotenoid
Biochemistry
Chromatography
Biology
Biotechnology
Organic chemistry
Computer science
Paleontology
Agronomy
Programming language
Physical chemistry
Gene
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202310.0987.v1
- https://www.preprints.org/manuscript/202310.0987/v1/download
- OA Status
- green
- Cited By
- 2
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387696712
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387696712Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.20944/preprints202310.0987.v1Digital Object Identifier
- Title
-
Design of Experiment Guided Establishment of a Fermentative Bioprocess for Biomass-Bound Astaxanthin with <em>Corynebacterium glutamicum</em>Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-18Full publication date if available
- Authors
-
Florian Meyer, Ina Schmitt, Thomas Schäffer, Volker F. Wendisch, Nadja A. HenkeList of authors in order
- Landing page
-
https://doi.org/10.20944/preprints202310.0987.v1Publisher landing page
- PDF URL
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https://www.preprints.org/manuscript/202310.0987/v1/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.preprints.org/manuscript/202310.0987/v1/downloadDirect OA link when available
- Concepts
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Astaxanthin, Corynebacterium glutamicum, Bioprocess, Aeration, Bioprocess engineering, Bioreactor, Chemistry, Biomass (ecology), Batch processing, Continuous stirred-tank reactor, Food science, Carotenoid, Biochemistry, Chromatography, Biology, Biotechnology, Organic chemistry, Computer science, Paleontology, Agronomy, Programming language, Physical chemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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92Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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